Cancer phylogenetic tree inference at scale from 1000s of single cell genomes by Salehi, Sohrab, Dorri, Fatemeh, Chern, Kevin, Kabeer, Farhia, Rusk, Nicole, Funnell, Tyler, Williams, Marc J., Lai, Daniel, Andronescu, Mirela, Campbell, Kieran R., McPherson, Andrew, Aparicio, Samuel, Roth, Andrew, Shah, Sohrab P., Bouchard-Côté, Alexandre

“…A new generation of scalable single cell whole genome sequencing (scWGS) methods allows unprecedented high resolution measurement of the evolutionary dynamics of cancer cell populations. Phylogenetic reconstruction is central to identifying sub-populations and distinguishing the mutational processes that gave rise to them. …”
Get full text

Production of Prodigiosin Using Tannery Fleshing and Evaluating Its Pharmacological Effects by C. Sumathi, D. MohanaPriya, S. Swarnalatha, M. G. Dinesh, G. Sekaran

“…IC50 concentration was cell line specific (HeLa cells: 4.3 µM, HEp2: 5.2 µM, and KB cells: 4.8 µM) and remains nontoxic up to the concentration of 25 µM on normal Vero cells suggesting that cancerous cells are more susceptible to the prodigiosin at lower concentration. …”
Get full text

A Green Approach to the Production of Hybrid Diindolylmethane-Phenylboronic Acids via a 3MCR: Promising Antineoplasic Molecules by Mónica Zarco Juarez, Joel Omar Martínez, Olivia Noguez Cordova, María Inés Nicolás Vazquez, Teresa Ramírez-Apan, Javier Pérez Flores, René Miranda Ruvalcaba, Gabriel Arturo Arroyo Razo

“…Moreover, the activity of these target molecules was evaluated in the presence of six cancer cell lines (U251 = glia of the central nerve system, PC-3 = prostate, K562 = leukemia, HCT-15 = colon, MCF-7 = breast, and SKLU-1 = lung), which resulted in the meta-regioisomer being the most active. …”
Get full text

ppENK Gene Methylation Status in the Development of Pancreatic Carcinoma by Lixin Yang, Hong Yang, Jingnan Li, Jianyu Hao, Jiaming Qian

“…Methylated ppENK was detected in all the pancreatic cancer cell lines and was associated with loss of mRNA expression in the pancreatic carcinoma cell lines and normal pancreatic tissue. …”
Get full text

Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal by Seyed Mohammad Doodmani, Payman Rahimzadeh, Najma Farahani, Seyedalireza Mirilavasani, Mina Alimohammadi, Noushin Nabavi, Elmira Alaei, Afshin Taheriazam, Maryam Abedi, Nadia Shafiee, Salman Daneshi, Mehrdad Hashemi

“…By inhibiting glycolysis, SFN can reduce the energy supply required for cancer cell proliferation. When combined with chemotherapy drugs, SFN enhances tumor suppression and mitigates drug resistance in human cancers. …”
Get full text

Inhibitory Effects of Polaprezine on the Inflammatory Response to Helicobacter pylori by Osamu Handa, Norimasa Yoshida, Yukiko Tanaka, Miho Ueda, Takeshi Ishikawa, Tomohisa Takagi, Naoyuki Matsumoto, Yuji Naito, Toshikazu Yoshikawa

“…To clarify the efficacy of polaprezinc, a chelate compound consisting of zinc and L-carnosine, against H pylori-induced inflammation including PMN infiltration, the in vitro effects of this drug on interleukin (IL)-8 production by an established gastric cancer cell line (MKN 45 cells) and on PMN-endothelial cell adhesive interactions was investigated. …”
Get full text

Halodule uninervis extract facilitates the green synthesis of gold nanoparticles with anticancer activity by Nadine Wehbe, Joelle Edward Mesmar, Riham El Kurdi, Ali Al-Sawalmih, Adnan Badran, Digambara Patra, Elias Baydoun

“…The produced AuNPs exhibited anticancer activity against several human cancer cell lines, highlighting their potential efficacy as anticancer therapeutic agents. …”
Get full text

Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment by Yanyan Zhang, Zhichao Yang, Yuchen Liu, Jinjin Pei, Ruojie Li, Yanhui Yang

“…Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. Moreover, lipid metabolism dysregulation within immune cells, particularly T cells, impairs immune surveillance and weakens the body’s defenses against cancer. …”
Get full text

New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia by Raha Orfali, Shagufta Perveen

“…All isolated metabolites were studied for their antibiotic effect against several pathogenic bacteria and for their cytotoxicity against the lymphoma human cancer cell line HTB-176. Austinol 3 exhibited strong antibacterial activity against P. aeruginosa bacterial strain with an MIC value of 0.13 ± 0.4 µg·mL−1, whereas emodin 4 demonstrated significant cytotoxicity against the tested HTB-176 cell line with an IC50 value of 2 ± 7.6 µM, while the other compounds were moderate to inactive with IC50 ranging from 4.3 ± 0.25–22 ± 2.94 µM in this assay.…”
Get full text

Identification and Characterization of a Novel Rat MAVS Variant Modulating NFκB Signaling by Ihsan Nalkiran, Hatice Sevim Nalkiran

“…The MAVS500 was cloned from the rat bladder cancer cell line, NBT-II, using specific primers, and subsequently sequenced. …”
Get full text

Development of a Semiconductor Sequencing-based Panel for Screening Individuals with Lynch Syndrome by Ryia-Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Janice Khor Sheau Sean, Sazuita Saidin, Mohd Ridhwan Abd Razak, Isa Md. Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal

“…The sensitivity and specificity of the identified mutations were determined by sequencing the serially diluted DNA from two human cancer cell lines, HCT 116 and LN-18. An average of 92 % of reads were mapped to the target region with 98 % uniformity. …”
Get full text

Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…Among these compounds cytotoxic agents such as bleomycin, paclitaxel and vincristine block essential pathways and genes required for cancer cell growth and these agents have diverse clinical applications. …”
Get full text

Integrated in silico and in vitro exploration of the anti-VEGFR-2 activities of a semisynthetic xanthine alkaloid inhibiting breast cancer. by Eslam B Elkaeed, Hazem Elkady, Ahmed M Khattab, Reda G Yousef, Hanan A Al-Ghulikah, Dalal Z Husein, Ibrahim M Ibrahim, Mohamed A Elkady, Ahmed M Metwaly, Ibrahim H Eissa

“…In vitro tests also demonstrated significant activity of T-1-NBAB against breast cancer cell lines MCF7 and T47D, with IC50 values of 16.88 μM and 61.17 μM, respectively, and high selectivity. …”
Get full text

ErbB4 as a Potential Molecular Target in the Treatment of Esophageal Squamous Cell Cancers by Ke Zhao, Bao-Jun Chen, Zhi-Guo Chen

“…Specifically, miRNA-140-5p inhibited/repressed the cancer cell invasion and migration in a sign to have important biological role in esophageal carcinomas. …”
Get full text

miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κB/Inflammatory Signaling Pathway by Bin Xie, Can Lu, Chen Chen, Jianhua Zhou, Zhenghao Deng

“…The complicated biological and molecular mechanisms underlying silica-induced lung damages have not yet been fully understood. miR-135a inhibits inflammation, apoptosis, and cancer cell proliferation. But the roles of miRNA135a involved in the silica-induced lung damages remain largely unexplored. …”
Get full text

PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib by Xin‐Yuan Lei, Kai‐Yue He, Qiu‐Tong Li, Lei Zhang, Dan‐Hui Wu, Jing‐Yu Yang, Jin‐Rong Guo, Meng‐Jie Liu, Zi‐Long Zhao, Jun‐Qi Li, Huai Liu, Yuan Zhao, Yu‐Jia Li, Qian‐Hui Sun, Chen‐Guang Wu, Yun‐Fan Wang, Geng‐Sheng Cao, Gang Wang, Yong‐Ping Jian, Zhi‐Xiang Xu

“…Taken together, these findings reveal a mechanistic link between HMGA1 and PARP1 in regulating cell responses to DNA damage and suggest that targeting HMGA1 could be a promising strategy to increase cancer cell sensitivity to olaparib.…”
Get full text

Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase by Thomas Große-Steffen, Thomas Giese, Nathalia Giese, Thomas Longerich, Peter Schirmacher, G. Maria Hänsch, Matthias M. Gaida

“…PMN as well as prevention of adhesion induced EMT also in liver cancer cell line. In conclusion, PMN via elastase induce EMT in vitro, most likely due to the loss of cell-to-cell contact. …”
Get full text

Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability by Joana Santos, Jorge Carvalho Silva, Manuel A. Valente, Tânia Vieira, Paula I.P. Soares

“…Magnetic hyperthermia (MH) is an innovative approach that uses superparamagnetic iron oxide nanoparticles (SPIONs) to increase the temperature locally, triggering cancer cell death. However, challenges related to the SPIONs coating impact their stability and MH heating mechanism, hindering its clinical adoption. …”
Get full text

Structural Modifications Reveal Dual Functions of the C-4 Carbonyl Group in the Fatty Acid Chain of Ipomoeassin F by Arman Khosravi, Precious Nnamdi, Alexa May, Kelsey Slattery, Robert E. Sammelson, Wei Q. Shi

“…Ipomoeassin F (Ipom-F) is a plant-derived macrocyclic resin glycoside that potently inhibits cancer cell growth through blockage of Sec61-mediated protein translocation at the endoplasmic reticulum. …”
Get full text

MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/β-Cateninsignaling Pathway by Xiaohong Wu, Yong Zhang, Junping Guo, Xun Yan, Li Shen, Jianping Zhou, Jun Zhao, Min Zhuang, Zhihong Cao

“…Present work showed the effect of downregulated MAC30 expression on proliferation and apoptosis of gastric cancer cell through Wnt/β-catenin signaling pathway. …”
Get full text