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1181
ADAMTS1, CRABP1, and NR3C1 Identified as Epigenetically Deregulated Genes in Colorectal Tumorigenesis
Published 2006-01-01“…Methods: With the use of microarrays, the gene expression profiles of colon cancer cell lines before and after treatment with the demethylating agent 5-aza-2′-deoxycytidine were identified and compared. …”
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1182
Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression
Published 2019-11-01“…Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. …”
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1183
Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones
Published 2017-01-01“…Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. …”
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1184
Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
Published 2015-01-01“…It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. …”
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1185
Mathematical modeling and treating tumors in a fuzzy environment
Published 2024-03-01“…Even though most documented investigations have not yet reached the competency needed for curing cancer, research has contributed to understanding the statistical principles governing cancer cell development, invasion, and proliferation. …”
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1186
Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk
Published 2025-02-01“…Validation using real-time PCR confirmed differential expression and methylation patterns of the identified genes in prostate cancer (PC3) and non-cancerous cell lines (PNT2). In conclusion, our study hihglights the DNA methylation biomarkers linked to PCa recurrence and introduces a promising SVM model for early prediction, potentially improving treatment outcomes. …”
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1187
Chaos in Physiological Control Systems: Health or Disease?
Published 2024-03-01“…In the context of disease, like for example growth of cancer cell populations, Chaos often refers to irregular and unpredictable patterns. …”
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1188
Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds
Published 2016-01-01“…It is also worth noting that the cytotoxicity of the synthesized indolylquinones in human breast cancer cell was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, with the 3-indolylisoperezone being the most active. …”
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1189
Preclinical Studies of Chemotherapy Using Histone Deacetylase Inhibitors in Endometrial Cancer
Published 2010-01-01“…HDACIs were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in a variety of endometrial cancer cell lines. Furthermore, HDACIs were able to induce the accumulation of acetylated histones in the chromatin of the p21WAF1 gene in human endometrial carcinoma cells. …”
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1190
Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases
Published 2015-03-01“…Eight compounds, combining the coumarin core and five membered heterocycles (isoxazoles and thiazoles) in hydrazinyldiene- -chroman-2,4-diones, were characterized in terms of a potential antiproliferative effect on bone (SCP1833) and lung (SCP4175) metastatic breast cancer cell lines using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay. …”
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1191
Electrospun short fibers: a new platform for cancer nanomedicine applications
Published 2023-12-01“…Herein, this paper provides an overview of the recent advances in the design of electrospun short fibers that retain the advantages of nanofibers with good dispersibility for different nanomedicine applications, including cancer cell capture, cancer treatments, and cancer theranostics. …”
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1192
Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression
Published 2009-01-01“…Many studies on SHP-1 revealed that the expression of this protein was diminished or abolished in several of the cancer cell lines and tissues examined. However, it is necessary to confront the cell lines data with real situation in cancer cases. …”
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1193
Ribociclib-induced vitiligo in a case of metastatic carcinoma of the breast
Published 2025-01-01“…While effective in inhibiting cancer cell proliferation, ribociclib has been associated with various dermatologic side effects, including vitiligo. …”
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1194
Reaction-Diffusion on a Spatial Mathematical Model of Cancer Immunotherapy with Effector Cells and IL-2 Compounds’ Interactions
Published 2021-01-01“…In this paper, we consider the interactions among the cancer cell population, the effector cell population that is a part of the immune system, and cytokines that can be used to stimulate the effector cells called the IL-2 compounds. …”
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1195
Dynamics and control of a mathematical model for metronomic chemotherapy
Published 2015-07-01“…A $3$-compartment model for metronomic chemotherapy that takes intoaccount cancerous cells, the tumor vasculature and tumorimmune-system interactions is considered as an optimal controlproblem. …”
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1196
C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity
Published 2013-01-01“…In vitro experiments in cancer cell lines showed that the selected derivatives (3a and 3f) exhibited higher antiproliferative potential than the parent compound, genistein, and were able to block the cell cycle in the G2/M phase. …”
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1197
Targeting RNA splicing modulation: new perspectives for anticancer strategy?
Published 2025-01-01“…In this review, we summarize the splice-altered signatures of cancer cell transcriptomes and the contributions of splicing aberrations to tumorigenesis and progression. …”
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1198
Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage
Published 2025-02-01“…Subsequently, the amyloid proteome of the RT4 non-invasive and HT1197 invasive bladder cancer cell lines was identified and included oncogenes, tumor suppressors, and highly expressed cancer-related proteins. …”
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1199
XMRV Discovery and Prostate Cancer-Related Research
Published 2011-01-01“…XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines. XMRV also traffics to prostate in a nonhuman primate model of infection. …”
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1200
PROTAC technology for prostate cancer treatment
Published 2025-01-01“…The metastatic spread of PrCa is the primary cause of mortality, causing cancer cell dissemination to distant sites, such as bones, the pelvis, and various visceral organs. …”
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