Liposomal encapsulation of cholecalciferol mitigates in vivo toxicity and delays tumor growth by Miriam Ezcurra-Hualde, Miriam Ezcurra-Hualde, Sara Zalba, Sara Zalba, Ángela Bella, Ángela Bella, Leire Arrizabalaga, Leire Arrizabalaga, Aline Risson, Aline Risson, Román García-Fuentes, Román García-Fuentes, Celia Gomar, Celia Gomar, Nuria Ardaiz, Nuria Ardaiz, Virginia Belsue, Virginia Belsue, David Ruiz-Guillamon, David Ruiz-Guillamon, Alejandro Serrano-Alcaide, Alejandro Serrano-Alcaide, Ainara Salgado, Ainara Salgado, Fernando Aranda, Fernando Aranda, Maria J. Garrido, Maria J. Garrido, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo

“…In vitro gene expression modulation was evaluated in monocytic THP-1 cells, and antiproliferative effects were assessed in HT29 (colorectal), BT474 (breast), and TRAMP-C1 (prostate) cancer cell lines. In vivo antitumor efficacy and toxicity were tested in a mouse model with subcutaneously implanted MC38 tumors. …”
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Synthesis and Biological Evaluation of 2,4-Diaminoquinazolines as Potential Antitumor Agents by Mohammad A. Alassaf, Khalid B. Selim, Magda N. A. Nasr

“…In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against a panel of four human cancer cell lines and for their DNA-binding affinity. …”
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From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery by Lijuan Xie, Fengxu Gan, Yun Hu, Yibin Zheng, Junshan Lan, Yuting Liu, Xiaofang Zhou, Jianyu Zheng, Xing Zhou, Jie Lou

“…Among them, platelet-mediated systems are particularly noteworthy for their innate tumor-homing and cancer cell interaction capabilities. These systems utilize nanoparticles shielded and directed by platelet membrane coatings for efficient drug delivery. …”
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PPARs Mediate Lipid Signaling in Inflammation and Cancer by Liliane Michalik, Walter Wahli

“…In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. …”
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Antiproliferative evaluation of various aminoquinoline derivatives by Zorc Branka, Rajić Zrinka, Perković Ivana

“…The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.…”
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Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases by D. Dreymueller, K. Theodorou, M. Donners, A. Ludwig

“…The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. …”
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A delay-differential equation model of HIV related cancer--immune system dynamics by Urszula Foryś, Jan Poleszczuk

“…In the paper we present a simple model of HIV related cancer - immune system interactions in vivo which takes into account a delay describing the time needed by CD$4^+$ T lymphocyte to regenerate after eliminating a cancer cell. The model assumes also the linear response of immune system to tumor presence.We perform a mathematical analysis of the steady states stability and discuss the biological meanings of these steady states. …”
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Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases by Alexander Desuki, Frank Staib, Ines Gockel, Markus Moehler, Hauke Lang, Stefan Biesterfeld, Annett Maderer, Peter R. Galle, Martin R. Berger, Carl C. Schimanski

“…LLGL1 was stably transfected into LLGL1 negative gastric cancer cell line SNU16 (del(17) (p11.2)) for functional in vitro assays and a xenograft bioassay. …”
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MicroRNA-21 as a Regulator of Cancer Stem Cell Properties in Oral Cancer by Milica Jaksic Karisik, Milos Lazarevic, Dijana Mitic, Maja Milosevic Markovic, Nicole Riberti, Drago Jelovac, Jelena Milasin

“…The principal objective of this study was to investigate the role of miRNA-21 in the maintenance of cancer cell stemness and the possibility of altering it. …”
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Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro by Pavić Kristina, Rajić Zrinka, Mlinarić Zvonimir, Uzelac Lidija, Kralj Marijeta, Zorc Branka

“…Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. …”
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On a mathematical model of bone marrow metastatic niche by Ana Isabel Muñoz, J. Ignacio Tello

“…The model consists of a coupled system of second order PDEs describing the evolution of CXCL-12 and PTHrP, an ODE of logistic type to model the Osteoblasts density and an extra equation for each cancer cell. We also simulate the system to illustrate the qualitative behavior of the solutions. …”
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Mathematical modeling of cyclic treatments of chronic myeloid leukemia by Natalia L. Komarova

“…One of the main causes for treatment failure in CML is thegeneration of drug resistance by mutations of cancerous cells. We usemathematical methods to develop general guidelines on optimal cyclictreatment scheduling, with the aim of minimizing the resistancegeneration. …”
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Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex by Mutasim Ibrahim Khalil, Aisha Mohamed Al-Zahem, Maha Hamad Al-Qunaibit

“…The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron.…”
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Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids by Jing Zhang, Xin-Ling Fu, Nan Yang, Qiu-An Wang

“…The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).…”
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Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers by Nooshafarin Shirani, Neda Abdi, Matin Chehelgerdi, Matin Chehelgerdi, Hajar Yaghoobi, Mohammad Chehelgerdi, Mohammad Chehelgerdi

“…It synthesizes current research findings on how these lncRNAs influence cancer cell survival, tumor microenvironment, and chemotherapy efficacy. …”
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Adenocarcinoma of the Colon Disguised as Abdominal Wall Abscess: Case Report and Review of the Literature by L. Attar, N. Trabulsi, A. A. Maghrabi, M. Nassif

“…Abdominal wall invasion by cancerous cells arising from the colon with an overlying secondary infection that presents as an abdominal wall abscess has been encountered previously, but such a symptom is rarely the first presentation of colon cancer. …”
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Lysyl oxidase inhibitors in colorectal cancer progression by Muxian Liu, Jie Wang, Meihong Liu

“…Numerous studies have demonstrated that LOX family members are dysregulated in a variety of cancers, including colorectal cancer (CRC), and play a key role in cancer cell migration, proliferation, invasion and metastasis. …”
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Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities by Aiman B. Awan, Maryiam Jama Ali Osman, Omar M. Khan

“…This comprehensive review delves into understanding the ubiquitin code, shedding light on its role in cancer cell biology and immune evasion. Furthermore, we highlighted recent advances in the field for targeting the UPS pathway members for effective therapeutic intervention against human cancers. …”
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Stemness-related gene signatures as a predictive tool for breast cancer radiosensitivity by Jinzhi Lai, Rongfu Huang, Jingshan Huang

“…We established a radioresistant BRCA cell line using the MCF-7 breast cancer cell line. A radioresistant breast cancer cell line (MCF-7/IR) was established by progressive exposure to increasing radiation doses. …”
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Synthesis, Characterization, and Antiproliferative Effect of CuO-TiO2-Chitosan-Amygdalin Nanocomposites in Human Leukemic MOLT4 Cells by Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah

“…The main aim of this study was to synthesize copper oxide- (CuO-) titanium oxide- (TiO2-) chitosan-amygdalin nanocomposites (CTCANc) and to characterize them physically and biologically (antimicrobial and anticancer activity using MOLT4 blood cancer cell line) to endorse their useful applications as potential drug candidates in anticancer avenues. …”
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