Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties by Jan Šťastný, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Tomáš Skala, Andrea Bernardos, Andrea Bernardos, Andrea Bernardos, Petr Maršík, Araceli Lérida-Viso, Araceli Lérida-Viso, Araceli Lérida-Viso, Jaroslav Matějka, Anna Mascellani Bergo, María Dolores Marcos, María Dolores Marcos, María Dolores Marcos, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ivan Jablonský, Pavel Klouček

“…Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration of the most active components in different species or genotypes, new formulation techniques are in development. …”
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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…Crucially, PERs modulate cancer cell behaviors including proliferation, apoptosis, and migration by influencing the levels of cell cycle proteins and stimulating the expression of oncogenes c-Myc and MDM2. …”
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Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents by Çevik Ulviye Acar, Osmaniye Derya, Levent Serkan, Sağlik Begüm Nurpelin, Çavuşoğlu Betül Kaya, Karaduman Abdullah Burak, Özkay Yusuf, Kaplancikli Zafer Asim

“…Among the tested compounds, compound 4y (N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(p-tolylamino)-1,3,4-thiadiazol-2-yl)thio)acetamide), showed promising cytotoxic activity against MCF7 cancer cell with an IC50value of 0.084 ± 0.020 mmol L−1 and against A549 cancer cell with IC50 value of 0.034 ± 0.008 mmol L−1, compared with cisplatin. …”
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Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy by Weijian Zhu, Qiang Yi, Zheng Chen, Jiaqi Wang, Kui Zhong, Xinting Ouyang, Kuan Yang, Bowei Jiang, Jianing Zhong, Jinghua Zhong

“…By stabilizing RAD18, MAGEA4 facilitates the recruitment of Y-family DNA polymerases, enabling cells to continue replication under DNA damage conditions and thus supporting cancer cell survival. MAGEA4-based TCR-T cell therapy and cancer vaccines show clinical potential. …”
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The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide by Guang Tan, Xin Zhang, Hongbo Feng, Haifeng Luo, Zhongyu Wang

“…This study is to investigate the role of the CIKs cocultured with K-ras-DCs in killing of pancreatic cancer cell lines, PANC-1 (K-ras+) and SW1990 (K-ras−). …”
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1H and 13C NMR Assignments of Cytotoxic 3S-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid from the Leaves of Cichorium endivia by Fu-Xin Wang, An-Jun Deng, Jin-Feng Wei, Hai-Lin Qin, Ai-Ping Wang

“…Cytotoxicity of this isolated compound against HCT-8 and HepG2 human cancer cell lines was evaluated for the first time, with moderate activities being found.…”
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Application of evolutionary games to modeling carcinogenesis by Andrzej Swierniak, Michal Krzeslak

“…We review a quite large volume of literature concerning mathematical modelling of processes related to carcinogenesis and the growth of cancer cell populations based on the theory of evolutionary games. …”
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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

“…These extracts were comparatively non-toxic to the normal human keratinocyte cell line, HaCaT, indicating its selective toxicity to cancerous cells. The cytomorphological changes associated with the chloroform extract and AO/EB dual staining indicated apoptotic cell death. …”
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Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis by Chao Zhang, Xiaolin Ji, Zhenguang Chen, Zhichao Yao

“…AC suppressed gastric cancer cell viability and restrained cell migration. …”
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2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities by Raman Singh, Vidushi Gupta, Antresh Kumar, Kuldeep Singh

“…The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. …”
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Extracellular vesicles display distinct glycosignatures in high-grade serous ovarian carcinoma by Kristina Mae Bienes, Akira Yokoi, Masami Kitagawa, Hiroaki Kajiyama, Morten-Thaysen Andersen, Rebeca Kawahara

“…Comparative glycoproteomics of small EVs (sEVs, <200 nm) and medium/large EVs (m/lEVs, >200 nm) isolated from HGSOC and non-cancerous cell lines revealed lower overall N-glycosylation of EV proteins and a decreased protein expression of oligosaccharyltransferase (OST) subunits from HGSOC compared to non-cancerous cell lines. …”
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METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling by Mei Pu, Xia Xiao, Shasha Lv, Daqing Ran, Qian Huang, Mingming Zhou, Qirong Lei, Lingshuang Kong, Qing Zhang

“…Elevating DLG2 levels significantly suppressed cervical cancer cell proliferation, migration, and invasion, while promoting apoptosis. …”
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Increased Expression of the Pro-Protein Convertase Furin Predicts Decreased Survival in Ovarian Cancer by Robert E. Page, Andrés J. P. Klein-Szanto, Samuel Litwin, Emmanuelle Nicolas, Raid Al-Jumaily, Peter Alexander, Andrew K. Godwin, Eric A. Ross, Russell J. Schilder, Daniel E. Bassi

“…Results: We found that furin expression was restricted to the cancer cell lines. In contrast, PACE-4 and PC-7 showed expression only in normal HOSE cells lines. …”
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Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs by Kawaljit Kaur, Angie Perez Celis, Anahid Jewett

“…Differentiated lung cancer cell line (H292) and NK cells differentiated hA549 expressed reduced NK cell-mediated cytotoxicity but expressed higher sensitivity to chemotherapeutic drugs. …”
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Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives by Jun-Rong Jiang, Feng Xu, Han-Gui Wu

“…These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell lines in vitro.…”
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An unbiased cell morphology-based screen for new, biologically active small molecules. by Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

“…Morphology-based screening of diverse cancer cell types has provided a method for discovering potent new small-molecule probes for cell biological studies and anticancer drug candidates.…”
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Oncogene OSTM1 Promotes Gastric-Cancer Metastasis by Modulating the Metastatic Microenvironment Through Altered Tumor-Cell Autocrine Signaling by Yucheng Tang, Yi Guo, Jiangyi Feng, Ziwei Wang

“…OSTM1 overexpression and knockdown cell lines were established to assess its effects on cancer-cell behavior through in vitro and in vivo experiments. …”
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Non-histone lactylation: unveiling its functional significance by Pusong Shi, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang

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Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria by Omer Abdalla Ahmed Hamdi, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, Sri Nurestri Abd Malek

“…Compounds (1–19) were evaluated for their antiproliferative effect using MTT assay against four cancer cell lines (Ca Ski, MCF-7, PC-3, and HT-29). …”
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CGH, cDNA and Tissue Microarray Analyses Implicate FGFR2 Amplification in a Small Subset of Breast Tumors by Mervi Heiskanen, Juha Kononen, Maarit Bärlund, Joachim Torhorst, Guido Sauter, Anne Kallioniemi, Olli Kallioniemi

“…According to CGH, the SUM‐52 breast cancer cell line harbors several high‐level DNA amplification sites, including the 10q26 chromosomal region where the fibroblast growth factor receptor 2 (FGFR2) gene has been localized. …”
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