Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor by Bynthia M. Anose, Michel M. Sanders

“…Data herein demonstrate that tcf8 is induced by dihydrotestosterone (DHT) in the human PC-3/AR prostate cancer cell line and that this induction is mediated by two androgen response elements (AREs). …”
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Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities by Hui Yang, Cui Wang, Qingjiang Wang, Feng Han

“…The ovarian cancer cell lines showed a dose-dependent decline in % cell viability. …”
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Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice by Debajit Bhowmick, Kaushik Bhar, Sanjaya K. Mallick, Subhadip Das, Nabanita Chatterjee, Tuhin Subhra Sarkar, Rajarshi Chakrabarti, Krishna Das Saha, Anirban Siddhanta

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Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner I... by Lianet Lopez, Hannah Shuster-Hyman, Eden Marco, Hasna Khan, Avishai Gasner, Aleksandra Uzelac, Brandon Wyse, Poonam Mander, Mugundhine Sangaralingam, Joseph Fish, Ariel Gorodensky, Samar Mouazz, Amanda Kauffman, Denis Gallagher, Andrée Gauthier-Fisher, Clifford L. Librach

“…Cancer cell- and donor-dependent paracrine effects on cancer cell growth were observed in vitro. …”
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NMD Microarray Analysis for Rapid Genome-Wide Screen of Mutated Genes in Cancer by Maija Wolf, Henrik Edgren, Aslaug Muggerud, Sami Kilpinen, Pia Huusko, Therese Sørlie, Spyro Mousses, Olli Kallioniemi

“…Such a “mutatomics” screening of prostate cancer cell lines led to the identification of inactivating mutations in the EPHB2 gene. …”
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Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides by Shengxian Zhao, Yin Cao, Zhenzhen Cui, Jiayun Zhang, Zhixiang Pan, Hongyu Hu

“…The synthesized compounds (5a–5o) were screened in vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay. …”
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Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells by K. Gouthamchandra, H.V. Sudeep, B.J. Venkatesh, K. Shyam Prasad

“…In the present study, we have used chlorogenic acid complex (CGA7) a decaffeinated water soluble green coffee bean extract to evaluate its cytotoxic effect on human and mouse cancer cell lines by using different approaches. From our results we found CGA7 treatment induces cell death in a dose and time dependent manner in different cancer cell lines. …”
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Colony-Forming and Cell Viability Assay to Assess Nanotoxicity of Maleic Acid and N-vinyl Caprolactam-Based Nanoarchitectures by Bekar Buse, Akar Burcu, Akan Handan Sevim, Can Hatice Kaplan

“…Nanocomposites significantly inhibited colony formation in both cancer cell lines, particularly in the HeLa cell line. …”
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Therapy of Prostate Cancer by Nanoyam Polysaccharide by Cheng Peng, Bo Han, Baishan Wang, Gaoyang Zhao, Fang Yuan, Yeyu Zhao, Liang Liang, Dingge Liu, Zhaohui Zhai, Yanping Shen

“…We evaluated the effect and mechanism of yam polysaccharide on the proliferation of the prostatic cancer cell line and tumor-bearing mice. The effect of nanoyam polysaccharide on prostatic cancer cell line PC-3 was measured using the scratch adhesion test and flow cytometry. …”
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Antitumor Activity of Whole-Plant Extracts from In Vitro Cultured and Wild-Growing <i>Clinopodium vulgare</i> Plants on a Panel of Human Tumor Cell Lines by Ani Georgieva, Inna Sulikovska, Tanya Toshkova-Yotova, Vera Djeliova, Sabrina Amiri, Nenad Tsonevski, Polina Petkova-Kirova, Krasimira Tasheva

“…The ability of <i>C. vulgare</i> to inhibit cancer cell migration and induce apoptosis in the tumor cells was examined by wound healing assay and fluorescence microscopic methods. …”
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Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived from <i>Bombyx mori</i> Silkworm for Enhanced Breast Cancer Treatment by Muhamad Hawari Mansor, Zijian Gao, Faith Howard, Jordan MacInnes, Xiubo Zhao, Munitta Muthana

“…In vitro studies demonstrated sustained cytotoxic effects, and cell cycle arrest at the G2/M phase in breast cancer cell lines, with minimal toxicity in non-cancerous cells. …”
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Antioxidant and cytotoxic potentials of Streptomyces gilvigriseus MUSC 26T isolated from mangrove soil in Malaysia by Hooi-Leng Ser, Wai-Fong Yin, Kok-Gan Chan, Tahir Mehmood Khan, Bey-Hing Goh, Learn-Han Lee

“…The resulting extract was used in antioxidant and invitro cytotoxicity assays against human colon cancer cell lines. The results showed that MUSC 26T extract possessed significant antioxidant activity and cytotoxic effect against the tested colon cancer cell lines. …”
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Synthesis, Structure, and Anticancerous Properties of Silver Complexes by Shraddha Shukla, A. P. Mishra

“…Although the “war on cancer” is now in its fourth decade and much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this dreaded disease, we still do not have a precise understanding of the differences between a cancer cell and its normal counterpart. The completion of the human genome sequence and its subsequent improvements in the sequence data are important steps to fully comprehend cancer cell biology. …”
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Assessment of Antioxidant and Cytotoxicity Activities of Saponin and Crude Extracts of Chlorophytum borivilianum by Mehdi Farshad Ashraf, Maheran Abd Aziz, Johnson Stanslas, Ismanizan Ismail, Mihdzar Abdul Kadir

“…Cytotoxicity evaluation of crude extract and total saponin fraction against MCF-7, PC3, and HCT-116 cancer cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) cell viability assay indicated a higher cytotoxicity activity of the crude extract than the total saponin fraction on all cell lines, being most effective and selective on MCF-7 human breast cancer cell line.…”
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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The three most active compounds: 4e (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-nitrobenzamide), 4f (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-chlorobenzamide) and 4g (4-bromo-N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)benzamide), were evaluated for anticancer activity against human OS cancer cell line (MG-63), liver cancer cell line (HepG2), lung cancer cell line (A549) and cervical cancer (HeLa), using MTT assay. …”
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Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells by Vladimir F. Niculescu

“…This work aims to highlight the emerging field of evolutionary cancer cell biology (ECCB), which points to the deep homology between cancer and protist life cycles tracing back to the common ancestor of amoebozoans, metazoans, and fungi (AMF). …”
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Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors by Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, Jieqing Liu, Junjie Ma

“…Importantly, 14 could upregulate the expression of PD-L1 and CXCL10 in a PD-L1 low-expression cancer cell line (MCF-7), highlighting the potential to enhance efficacy by recruiting T-cell infiltration into TME and improving the response of PD-1/PD-L1 inhibitor associated with PD-L1 low-expression. …”
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GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma by Toshihiko Inowa, Keiichi Hishikawa, Yumi Matsuzaki, Takayuki Isagawa, Takumi Takeuchi, Hiroyuki Aburatani, Tadaichi Kitamura, Toshiro Fujita

“…Side population (SP) cells are an enriched population of stem, and the existence of SP cells has been reported in human cancer cell lines. In this study, we performed an SP analysis using 11 human cancer cell lines and confirmed the presence of SP cells in an embryonic carcinoma cell line, NEC8. …”
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A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems by Thuc Ngoc Dinh, Mai Vu Thi Ha, Luong Ngo Xuan, Huan Trinh Thi, Huong Nguyen Thi, Mai Nguyen Thi Ngoc, Giap Tran Huu, Oanh Vu Thi Kim, Thanh Le Nguyen

“…Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 8–10 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively.…”
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In Vitro Model for Studying Malignancy Associated Changes by Xiao Rong Sun, Yonghong Zheng, Calum MacAulay, Stephen Lam, Alexei Doudkine, Branko Palcic

“…In this study we examined changes in nuclear features of normal human bronchial epithelial cells (NHBE) when they were co‐cultured with cells derived from a lung cancer cell line NCI‐H460. Using discriminant function analysis, nuclear features were determined which allow maximal discrimination between normal cells incubated with or without cancerous cells. …”
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