Self-assembled Human Serum Protein-based Core-shell Nanoparticles to inhibit key oncogenic signalling in Drug-Resistant Leukemia by Archana Payickattu Retnakumary, Lekshmi G Kumar, Neeraj Sidharthan, Pavithran Keechilat, Giridharan L. Malarvizhi, Prasanna L Hanumanthu, Madhavan V Thampi, Deepthy Menon, Krishnakumar Menon, Shantikumar V Nair, Manzoor Koyakutty

“…1730388865"> Simultaneous inhibition of multiple oncogenic signaling pathways is crucial for managing refractory cancers. This study introduces two unique core-shell nanoparticle (CS-NP) systems crafted from natural proteins that simultaneously target two crucial oncogenic pathways in refractory chronic myeloid leukemia (CML). …”
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Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development by Haijun Zhang, Lin Zhang, Ziqi Wu

“…Abstract Background Dysregulation of SF3A3 has been related to the development of many cancers. Here, we investigated the functional role of SF3A3 in hepatocellular carcinoma (HCC). …”
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Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol. by Zoe-Anne V Baldwin, Steph Busby, David Allsup, Judith Cohen, Olufikayo Bamidele

“…<h4>Introduction</h4>Haematological malignancies are a heterogenous group of blood and lymphatic cancers. Survivorship care is a similarly diverse term concerning patients' health and wellbeing from diagnosis to end of life. …”
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Short-Term Clinical Outcomes after Using Novel Deeper Intubation Technique (DIT) of Ileus Tube for Acute Bowel Obstruction Patients by Yanlu Tan, Haibin Chen, Wenji Mao, Qin Yuan, Jun Niu

“…In addition, the DIT procedure was effective for patients with adhesive obstruction but not for cancerous and stercoral bowel obstruction. Conclusion. …”
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Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. by Peihong Dai, Weiyi Wang, Hua Cao, Francesca Avogadri, Lianpan Dai, Ingo Drexler, Johanna A Joyce, Xiao-Dong Li, Zhijian Chen, Taha Merghoub, Stewart Shuman, Liang Deng

“…Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to understand how MVA modulates innate immunity in dendritic cells (DCs), which can provide insights to vaccine design. …”
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Correlation between microRNA-21 expression and overweight/obesity by Shashwat Sinha, Babu Rajendran, Shomnath Vasagam, Jeyakumar Balakrishnan

“…Recent studies have proven that microRNA-21 causes the systemic hypertension, many cardiac pathologies, and some cancers. MicroRNA-21 is viewed as an important future biomarker for many critical conditions. …”
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‘Photodynamic therapy light’: An enhanced treatment protocol for actinic keratoses with minimal pain and optimal clinical outcome by combining laser-assisted low irradiance PDT wit... by Martin T. Braun, Kelly Del Tredici, Anna Wölling, Luitgard Wiest

“…Patients with AK Olsen grades 1 or 2 and field cancerization initially received a mild-fractionated CO2 laser pretreatment prior to MAL-incubation (methyl aminolaevulinate, Metvix ®) under occlusion for 1.5–3 h. …”
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Multipotent Effect of Clozapine on Lipopolysaccharide-Induced Acetylcholinesterase, Cyclooxygenase-2,5-Lipoxygenase, and Caspase-3: In Vivo and Molecular Modeling Studies by Minhajul Arfeen, Devendra Kumar Dhaked, Vasudevan Mani

“…Dual inhibition of cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) is a recognized strategy for enhanced anti-inflammatory effects in small molecules, offering potential therapeutic benefits for individuals at risk of dementia, particularly those with neurodegenerative diseases, common cancers, and diabetes type. Alzheimer’s disease (AD) is the most common cause of dementia, and the inhibition of acetylcholinesterase (AChE) is a key approach in treating AD. …”
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Determination of antibacterial and antioxidant potential of organic crude extracts from Malus domestica, Cinnamomum verum and Trachyspermum ammi by Asma Irshad, Rabbia Jawad, Qudsia Mushtaq, Alexis Spalletta, Patrick Martin, Uzair Ishtiaq

“…Abstract Plants are the rich source of biologically active compounds which can be obliging against various pathogenic microorganisms and cancerous diseases. The current study evaluated the antibacterial potential of aqueous, methanol, ethanol, and acetone extracts of Malus domestica (apple), Cinnamomum verum (cinnamon) and Trachyspermum ammi (ajwain) via agar well diffusion methods and minimum inhibitory concentration (MIC) in (mm) against Staphylococcus aureus (ATCC 25923) and Salmonella typhi (ATCC 19430). …”
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Engineering and design of a COF-coated probe for the detection and removal of flumequine and enrofloxacin antibiotics in foodstuffs: a molecular dynamics simulation approach by Alireza Nakhaei, Heidar Raissi, Maryam Alaei, Farzaneh Farzad

“…However, their overuse can lead to significant health risks, including water contamination, antibiotic-resistant pathogens, kidney disease, reproductive disorders, cancers, and severe allergic reactions. Among the frequently used fluoroquinolones are enrofloxacin and flumequine, both of which are essential in various therapeutic applications. …”
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Gallbladder Carcinomas: An Immunoprognostic Evaluation of P53; Bcl-2; CEA and Alpha-Fetoprotein by R Kanthan, JM Radhi, SC Kanthan

“…The p53 gene is the most frequently mutated gene in many human cancers, including those of the colon, breast, lung, esophagus, liver and brain. …”
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Chromosomal Regions in Prostatic Carcinomas Studied by Comparative Genomic Hybridization, Hierarchical Cluster Analysis and Self-Organizing Feature Maps by Torsten Mattfeldt, Hubertus Wolter, Danilo Trijic, Hans‐Werner Gottfried, Hans A. Kestler

“…Moreover, for the pT2N0‐ and pT3N0‐groups, it could be shown that the regions 6q, 8p and 13q lay all on the same cluster (associated with losses), and that the regions 9q and 20q belonged to the same cluster (associated with gains). For the incidental cancers such clear correlations could not be demonstrated.…”
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Burnout in healthcare – the Emperor’s New Clothes by Wojciech Marlicz, Anastasios Koulaouzidis, Dafni Charisopoulou, Janusz Jankowski, Maria Marlicz, Karolina Skonieczna-Zydecka, Patrycja Krynicka, Igor Loniewski, Jerzy Samochowiec, Grażyna Rydzewska, George Koulaouzidis

“…As the number of patients with cancers, psychiatric and neurodegenerative disorders will rise, we need new solutions to maintain physicians’ health and, therefore, quality of care. …”
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Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma by Zhuning Wang, Junqiao Yao, Tengyu Dong, Xing Niu

“…Cuproptosis is a newly discovered copper-independent cell death modality, and limited evidence suggests the critical implications in human cancers. Nonetheless, the clinical impacts of cuproptosis-relevant lncRNAs in lung adenocarcinoma (LUAD) remain largely ill-defined. …”
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Classification of white blood cells (leucocytes) from blood smear imagery using machine and deep learning models: A global scoping review. by Rabia Asghar, Sanjay Kumar, Arslan Shaukat, Paul Hynds

“…Machine learning (ML) and deep learning (DL) models are being increasingly employed for medical imagery analyses, with both approaches used to enhance the accuracy of classification/prediction in the diagnoses of various cancers, tumors and bloodborne diseases. To date however, no review of these techniques and their application(s) within the domain of white blood cell (WBC) classification in blood smear images has been undertaken, representing a notable knowledge gap with respect to model selection and comparison. …”
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The viral and cellular microRNA targetome in lymphoblastoid cell lines. by Rebecca L Skalsky, David L Corcoran, Eva Gottwein, Christopher L Frank, Dong Kang, Markus Hafner, Jeffrey D Nusbaum, Regina Feederle, Henri-Jacques Delecluse, Micah A Luftig, Thomas Tuschl, Uwe Ohler, Bryan R Cullen

“…Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. …”
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In Vitro and In Vivo Characterization of Three Ga- and In-Labeled Peptides for Cholecystokinin Receptor Imaging by Susan Roosenburg, Peter Laverman, Lieke Joosten, Annemarie Eek, Floris P.J.T. Rutjes, Floris L. van Delft, Otto C. Boerman

“…Cholecystokinin (CCK) receptors are overexpressed in several human tumor types, such as medullary thyroid carcinomas and small cell lung cancers. Several ligands for the CCK2 receptor (CCK2R) have been developed for radionuclide targeting of these tumors. …”
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Exogenous Janus Kinase 617 Codon Influences Small Noncoding RNAs and Gene Expression in Ba/F3 Cells by Yi-Yang Chen, Ying-Hsuan Wang, Chih-Cheng Chen, Cih-En Huang, Chia-Chen Hsu, Shu-Huei Hsiao, Yu-Wei Leu

“…Myeloproliferative neoplasms (MPNs) are blood cancers caused by mutations that originate from hematopoietic stem cells. …”
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Expression of a Secretory Protein C1qTNF6, a C1qTNF Family Member, in Hepatocellular Carcinoma by Tamotsu Takeuchi, Yoshihiro Adachi, Tomoko Nagayama

“…Results: C1qTNF6 was not immunohistochemically detected in any non-cancerous liver tissues but was detected in 21 of 30 hepatocellular carcinoma tissue specimens. …”
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Pathogenicity role of human herpesvirus-8 in patients with acute myeloid leukemia by Zahraa Ali Abdullah, Luma Amer Yasir, Ruqaya Munther J. Ewadh, Shakir H. Mohammed Al. Alwany

“…BACKGROUND: Certain hematologic cancers, including Kaposi’s sarcoma (KS), have been associated with the pathogenicity of human herpesvirus-8 (HHV-8). …”
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