Xeroderma Pigmentosum with Severe Neurological Manifestations/De Sanctis–Cacchione Syndrome and a Novel XPC Mutation by Esteban Uribe-Bojanini, Sara Hernandez-Quiceno, Alicia María Cock-Rada

“…We present a case of a 12-year-old Colombian male, with multiple skin lesions in sun-exposed areas from the age of 3 months and a history of 15 skin cancers. He also displayed severe neurologic abnormalities (intellectual disability, ataxia, altered speech, and hyperreflexia), short stature, and microcephaly, which are features associated with DSC. …”
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Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis by Fan Ye, Ziran Zhang, Lianjun Shi, Shuting Lu, Xiumiao Li, Wan Mu, Qin Jiang, Biao Yan

“…Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases. In this study, we elucidate the role of tsRNA-0032 in lymphangiogenesis and its molecular mechanism. tsRNA-0032 expression is significantly decreased in corneal suture model and human lymphatic endothelial cell (HLEC) model under inflammatory condition. …”
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Rapid Visualization of Human Tumor Xenografts through Optical Imaging with a Near-Infrared Fluorescent Anti–Epidermal Growth Factor Receptor Nanobody by Sabrina Oliveira, Guus A.M.S. van Dongen, Marijke Stigter-van Walsum, Rob C. Roovers, Jord C. Stam, Willem Mali, Paul J. van Diest, Paul M.P. van Bergen en Henegouwen

“…Given that overexpression of the epidermal growth factor receptor (EGFR) is found in many types of human epithelial cancers, noninvasive molecular imaging of this receptor is of great interest. …”
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Comparative analysis of galectin-1, galectin-3, and galectin-8 signatures in normal and choriocarcinoma trophoblast cell lines by Jovanović Krivokuća Milica, Legner Janko, Ćujić Danica, Vilotić Aleksandra, Grubiša Ivana, Vićovac Ljiljana, Bojić-Trbojević Žanka

“…Altered expression profiles of galectins are linked to various cancers. This study explores the expression and localization of galectins -1, -3, and -8 in a normal extravillous HTR-8/SVneo cell line and two choriocarcinoma cell lines, JAR and JEG-3. …”
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Inverse Gini indexed averaging: A multi-leveled ensemble approach for skin lesion classification using attention-integrated customized ResNet variants by Anwar Hossain Efat, SM Mahedy Hasan, Md Palash Uddin, Faysal Hossain Emon

“…Objective To improve the accuracy and explainability of skin lesion detection and classification, particularly for several types of skin cancers, through a novel approach based on the convolutional neural networks with attention-integrated customized ResNet variants (CRVs) and an optimized ensemble learning (EL) strategy. …”
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LAMB1 downregulation suppresses glioma progression by inhibiting aerobic glycolysis through regulation of the NF-κB/HK2 axis by Zhenxiang Zhao, Haiying Liu, Yingzi Liu, Junpeng Wen, Jiangwei Yuan

“…Abstract Background Laminin subunit beta 1 (LAMB1) has regulatory functions on the proliferation, attachment, and migration of tumor cells, with increased levels linked to different cancers. Objective This study aims at investigating the effects and mechanisms of LAMB1 in glioma. …”
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A Case of Nivolumab-Induced Severe Mononeuropathy Multiplex and Rhabdomyolysis by Katsuya Sakai, Hitoshi Mochizuki, Kosuke Mochida, Kazutaka Shiomi, Masahiro Amano, Masamitsu Nakazato

“…Nivolumab, an immune checkpoint inhibitor, is used for the treatment of advanced melanoma and other cancers and causes various immune-related adverse events (irAEs). …”
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Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide by Georgios Gaitanis, Dora Gougopoulou, Eleni Kapsali, Ioannis D. Bassukas

“…In conclusion, the impressive and sustainable AK remission under anagrelide draws attention to a possible role of the phosphodiesterase 3 pathway, the major pharmacological target of anagrelide, as a potential therapeutic target for keratinocytic cancers.…”
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Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains by Arun John, Vetrivel Umashankar, Subramanian Krishnakumar, Perinkulam Ravi Deepa

“…This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. This has made FASN an attractive pharmacological target. …”
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NeuroSight: A Deep‐Learning Integrated Efficient Approach to Brain Tumor Detection by Shafayat Bin Shabbir Mugdha, Mahtab Uddin

“…This approach facilitates deep‐learning researchers in identifying and categorizing brain cancers by comparing recent papers and assessing deep‐learning methodologies.…”
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Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Lit... by Narciss Mobini, Rummit Dhillon, Jason Dickey, Jordan Spoon, Kaviyon Sadrolashrafi

“…Recent emergence of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of cancers and produced prolonged response by boosting the immune system against tumor cells. …”
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Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections by Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin

“…Abstract Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS. …”
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Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus by Julio Alonso-Padilla, Esther M. Lafuente, Pedro A. Reche

“…EBV infection is also linked to various cancers, including Burkitt’s lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. …”
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Study of tomato growers' cultural practices and risks associated with the unreasoned use of chemical inputs in the Adamawa Region, Cameroon by Ramsès Tsala, Zacharie Bounyahré Mounkéné, Gaston Dimitri Amia, Maïmouna Abba, Lucien Tatchum Tchuenteu, Clautilde Megueni

“…These poor practices can lead to cancerous diseases, spontaneous abortions, lower IQs and the degradation of ecosystem biodiversity. …”
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Epithelial–Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells by Keisuke Takemura, Kyohei Ikeda, Hayato Miyake, Yoshio Sogame, Hiroaki Yasuda, Nobuhiro Okada, Kazumi Iwata, Junichi Sakagami, Kanji Yamaguchi, Yoshito Itoh, Atsushi Umemura

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in the world. Neoadjuvant chemotherapy (NAC) has become a standard treatment for patients scheduled for surgical resection, but the high rate of postoperative recurrence is a critical problem. …”
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Production of Prodigiosin Using Tannery Fleshing and Evaluating Its Pharmacological Effects by C. Sumathi, D. MohanaPriya, S. Swarnalatha, M. G. Dinesh, G. Sekaran

“…IC50 concentration was cell line specific (HeLa cells: 4.3 µM, HEp2: 5.2 µM, and KB cells: 4.8 µM) and remains nontoxic up to the concentration of 25 µM on normal Vero cells suggesting that cancerous cells are more susceptible to the prodigiosin at lower concentration. …”
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Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma by Annika Simone Lück, Jingjing Pu, Ahmad Melhem, Matthias Schneider, Amit Sharma, Ingo G. H. Schmidt-Wolf, Jarek Maciaczyk

“…Abstract Despite the favorable effects of immunotherapies in multiple types of cancers, its complete success in CNS malignancies remains challenging. …”
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Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma by Sunida Rewsuwan, Nopporn Satabongkoch, Prapaporn Suprasert, Surapan Khunamornpong

“…Carcinosarcoma is an uncommon form of ovarian cancers, classified as being part of the group of mixed epithelial and mesenchymal tumors. …”
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Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors by Gang Li, Jing Zhang, Bentuo Zhang, Dan Wang, Zequn Wang, Yan Pan, Lijie Ma

“…We found that in pNET development and metastasis, 11 genes and 14 circRNAs were notably upregulated, while 25 genes and 35 circRNAs were significantly downregulated, compared to nearby non-cancerous tissue. Our analysis of differentially expressed RNA and circRNA genes revealed that tumor cell adhesion and integrin activation, regulated by genes like PIEZO1, IFT74, SKAP1, GPX1, F7, VTN, and OMG, are strongly linked to pNET metastasis. …”
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Fractal dimensions in oral squamous cell carcinoma: A novel diagnostic paradigm by Ramkumar Ravichandran, Nagarathinam Anbu Elangovan, Rajkumar Krishnan, Dominic S, Dinesh Kumar Thayalan, Supriya Ponsingh

“…Fractal dimension analysis is a novel computational method that quantifies the intricacy and irregularity of structures, and has demonstrated potential in numerous medical applications, such as the analysis of cancerous tissues. Our study investigated the utility of fractal dimension analysis in differentiating normal mucosa from oral squamous cell carcinoma (OSCC). …”
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