A Case Report of Spindle Cell (Sarcomatoid) Carcinoma of the Larynx by Harry Boamah, Billy Ballard

“…Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. …”
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Composite submental flaps in facial reconstructive surgery involving the zygoma and orbit by Usman Khan, Sebastian Haupt, Matthew Rigby, S. Mark Taylor, Martin Corsten, Jonathan Trites

“…All were performed following resection of skin cancers with invasion of the upper facial skeleton. …”
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Multiple Low Energy Long Bone Fractures in the Setting of Rothmund-Thomson Syndrome by Nicholas Beckmann

“…Rothmund-Thomson syndrome is a rare autosomal recessive genodermatosis characterized by a poikilodermatous rash starting in infancy as well as various skeletal anomalies, juvenile cataracts, and predisposition to certain cancers. Although Rothmund-Thomson syndrome is associated with diminished bone mineral density in addition to multiple skeletal abnormalities, there are few reports of the association with stress fractures or pathologic fractures in low energy trauma or delayed healing of fractures. …”
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A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies by Ammar ELJack, Mohamad El Abdallah, Kadhim Al-Banaa, Kashif Chaudhry, Faisal Musa

“…It happens frequently in cancers receiving chemotherapy, particularly hematological malignancies. …”
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Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors by Runhan Liu, Jiaxin Zhou, Xiaochen Chen, Jie Zhang, Qunzhi Chen, Xiaoming Liu, Kunhou Yao

“…This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. …”
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Contrast-Enhanced Mammography in the Diagnosis of Breast Angiosarcoma by Maya Grisaru Kacen, Nikhil Sangle, Anat Kornecki

“…Breast angiosarcoma is a rare entity that represents less than 1% of all breast cancers. To our knowledge, this is the first case describing the imaging findings of breast angiosarcoma on contrast-enhanced mammography.…”
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Hedgehog pathway inhibitors (HHI) combined with radiotherapy and immunotherapy for advanced basal cell carcinoma: a case report by Zhuren Ruan, Chen Zhao, Longshan Li, Xianghui Li, Zhijian Yao, Gao Wei

“…Purpose Basal cell carcinoma (BCC) is one of the most common skin cancers. Most BCCs can be treated with surgery excision. …”
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Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management by Anam YOUSAF, Sarina SULONG, Baharudin ABDULLAH, Norhafiza Mat LAZIM

“…This review presents the most recent advances in the molecular pathology of salivary gland cancers, with an emphasis on distinguishing molecular features that can be used for optimizing current patient management.…”
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Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking by In Won Lee, Jonghwan Yoon, Gunhee Lee, Minho Lee

“…Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers, because its expression is associated with resistance to DNA-damaging anticancer agents. …”
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Emerging roles of checkpoint molecules on B cells by Hiromitsu Asashima, Satoshi Akao, Isao Matsumoto

“…During the last decades, immunotherapies targeting these molecules (such as programmed cell death 1 (PD-1), and lymphocyte activation gene 3 (LAG-3)) have provided clinical benefits in many cancers. It is becoming apparent that not only T cells, but also B cells have a capacity to express some checkpoint molecules. …”
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A Bayesian Hierarchical Model for Relating Multiple SNPs within Multiple Genes to Disease Risk by Lewei Duan, Duncan C. Thomas

“…The method is applied to data on 504 SNPs in 38 candidate genes involved in DNA damage response in the WECARE study of second breast cancers in relation to radiotherapy exposure.…”
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Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma by Yun Cao, Wei Zhang, Yi-Ting Jin, Qiang Zou

“…Heterogeneous nuclear ribonucleoproteins (HNRNPs) are crucial members in the pathogenesis and progression of numerous cancers. However, the expression pattern and clinical significance of HNRNPs in breast carcinoma (BC) remain to be investigated. …”
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Differentiation therapy targeting the stalled epigenetic developmental programs in pediatric high-grade gliomas by Wang Xiang, Xiaolin Zhang, Minhai Dong, Lijun Wan, Bin Zhang, Feng Wan

“…Although challenges remain in overcoming tumor cell heterogeneity, induced differentiation therapy holds promise for treating these currently incurable pediatric brain cancers.…”
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Morphological and endoscopic diagnostic criteria of serrated adenomas of the colon by A. M. Nechipay, M. V. Zobnina, L. M. Cherkasova, I. B. Perfilyev, V. A. Krivopuskov

“…At the present time hyperplastic polyps and other serrated neoplasms are considered to be precursor lesions for 15 to 20% of sporadic or asymptomatic colorectal cancers located mainly in proximal colon, that progress by specific serrated adenoma-related pathway. …”
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The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression by Yayun Zheng, Xue Ma, Dongmei Su, Yue Zhang, Lin Yu, Fangfei Jiang, Xue Zhou, Ying Feng, Fang Ma

“…Siglec7 and Siglec9 are very similar in distribution, gene encoding, protein sequences, ligand affinity, and functions in regulating the immune system against virus and cancers, but differences still exist between them. …”
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TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses by Gilmara Barros de Lima, Everton Nencioni, Fábio Thimoteo, Camila Perea, Rafaela Fuzaro Alves Pinto, Sergio Daishi Sasaki

“…Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. …”
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A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia by Bhawna Sethi, K. S. Butola, Yogesh Kumar

“…It is an uncommon disease with overall incidence of approximately 3 per million persons per year, accounting for approximately 1% to 2% of all hematologic cancers. It has only one-sixth the estimated prevalence of plasma cell myeloma. …”
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The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases by Keshav Raj Sigdel, Ao Cheng, Yin Wang, Lihua Duan, YanLin Zhang

“…The lncRNAs play crucial role in various multigenetics human diseases including cancers and neurological diseases and currently its role in autoimmune diseases is attracting many researchers. …”
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Osteoradionecrosis of the Temporal Bone Leading to Cerebellar Abscess by Thomas B. Layton

“…One feared complication of radiotherapy is osteoradionecrosis and is a major obstacle faced in the treatment of head and neck cancers. The case presented here is a rare example of a patient who was successfully treated for SCC of the temporal with both surgical resection and adjuvant radiotherapy who subsequently developed two major complications: first, osteoradionecrosis of the temporal bone that leads to penetrating osteomyelitis; second, the formation of a large cerebellar abscess that required surgical drainage. …”
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Menopause mysteries: the exosome-inflammation connection by Aarushi Sultania, Subhashini Brahadeeswaran, Aparna Eledath Kolasseri, Sivaraman Jayanthi, Ramasamy Tamizhselvi

“…It can also act as a precursor to more severe health problems, including neurological, cardiovascular, and metabolic diseases, as well as gynecological cancers. Researchers have discovered pathways that reveal the diverse effects of exosome-driven cellular communication and oocyte development in the follicular fluid. …”
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