From the Guest Editors by Alberto d’Onofrio, Paola Cerrai, Alberto Gandolfi

“…A genuine explosion of data concerning themulti-faceted aspects of this family of phenomena collectively called cancers,is now becoming available. At the same time, it is becoming quite evident thattraditional tools from biostatistics and bioinformatics cannot manage thesedata. …”
Get full text

Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

“…Abstract Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. …”
Get full text

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy by Ichiro Yajima, Mayuko Y. Kumasaka, Nguyen Dinh Thang, Yuji Goto, Kozue Takeda, Osamu Yamanoshita, Machiko Iida, Nobutaka Ohgami, Haruka Tamura, Yoshiyuki Kawamoto, Masashi Kato

“…Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. …”
Get full text

Renal Cell Carcinoma Masquerading as Acute Upper Gastrointestinal Bleeding by Aadesh Rayamajhi, Saurav Agrawal, Sandesh Rayamajhi, Manoj Lamsal, Dinesh Koirala

“…Acute upper gastrointestinal bleeding (UGIB) is a medical emergency with most common cause being peptic ulcer disease (PUD) or variceal bleeding. However, cancers that cause UGIB by invading the small intestine are uncommon, and the invasion of renal cell carcinoma (RCC) into the duodenum is an even rarer occurrence. …”
Get full text

Development and Validation of a Simple and Selective Analytical HPLC Method for the Quantification of Oxaliplatin by Breno Noronha Matos, Paula Martins de Oliveira, Thaiene Avila Reis, Taís Gratieri, Marcílio Cunha-Filho, Guilherme Martins Gelfuso

“…Such method will be essential during the future development of innovative, topical drug formulations for the treatment of mucosal and skin cancers. Validated method demonstrated OXPt separation without interference from the solvents or polymers with the most relevance for developing of bioadhesive pharmaceutical drug carries (chitosan and poloxamer). …”
Get full text

Citrus Flavonoid Effects on Obesity by Yu Wang, Laura E. Reuss

“…Obesity, a chronic disease that increases the risk for a myriad of diseases including diabetes, hypertension, cardiovascular diseases, as well as certain types of cancers, results from a persistent excess of energy intake versus energy expenditure and is characterized by an increase in both adipose cell size and number. …”
Get full text

Citrus Flavonoid Effects on Obesity by Yu Wang, Laura E. Reuss

“…Obesity, a chronic disease that increases the risk for a myriad of diseases including diabetes, hypertension, cardiovascular diseases, as well as certain types of cancers, results from a persistent excess of energy intake versus energy expenditure and is characterized by an increase in both adipose cell size and number. …”
Get full text

STAT3 Expression and Its Correlation with PD-L1 Expression in Non-Hodgkin’s Lymphoma and Hodgkin’s Lymphoma at Dr. Saiful Anwar Regional Public Hospital in Malang, Indonesian Popul... by Ailen Oktaviana Hambalie, Eviana Norahmawati, Agustina Tri Endharti, Diah Prabawati Retnani, Nayla Rahmadiani

“…Lymphomas are malignant lymphocyte neoplasms that globally account for 10% of cancers in individuals aged <20 years. Malignant lymphomas are divided into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). …”
Get full text

Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging by Zhang Y, Liu F, Shao C, Huang J, Yan G

“…Recently fluorescence-guided surgery for tumors to delineate between cancerous and healthy tissues has attracted widespread attention. …”
Get full text

Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71 by Rosalba Parenti, Lucia Salvatorelli, Gaetano Magro

“…Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers. Actually, ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine (131I) therapy. …”
Get full text

Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma by Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang

“…Hepatocellular carcinoma (HCC) is one of the most common lethal cancers worldwide. Natural killer cells (NK cells) play a key role in liver immunosurveillance, but in the tumor microenvironment, NK cells are readily depleted, as evidenced by down-regulation of activating receptors, reduced cytokine secretion, and attenuated killing function. …”
Get full text

Oxidative stress: an overview of past research and future insights by Aaser M. Abdelazim, Mosleh M. Abomughaid

“…The obtained findings suggest that many diseases are linked to OS, including diabetes mellitusinflammation, cancers, autoimmune disorders and neurodegenerative diseases. …”
Get full text

Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass by Antonio Maietta, Maryam Razmpoosh

“…Erdheim-Chester disease rarely can be associated with other cancers, namely myeloid neoplasms. We report a case of Erdheim-Chester disease presenting with small lymphocytic lymphoma as a perirenal mass. …”
Get full text

Multilayer Mie Scattering Model for Investigation of Intracellular Structural Changes in the Nucleolus and Cytoplasm by S. Saltsberger, I. Steinberg, I. Gannot

“…Such changes are related with cancerous processes within the cell as well as other cell pathologies. …”
Get full text

Facts about Antioxidants by Kaitlin G. Clark, Wendy J. Dahl

“…Antioxidants also can help our immune system defend against bacteria, fungi, viruses, and some cancers. The body produces some of its own antioxidants, but eating a plant-based diet increases the level of antioxidants in our bodies. …”
Get full text

Peutz–Jeghers syndrome – Be in need of vigilance: A case report by Vandana S. Tomey, Sudhir Tomey, Kewal Dhone, Tanmay Tapase

“…Peutz–Jeghar syndrome (PJS) is an inherited condition that puts people at an increased risk for developing hamarotmatous polyps in the digestive tract as well as cancers of the breast, colon, rectum, pancreas, stomach, testicles, ovaries, lung and cervix. …”
Get full text

Facts about Antioxidants by Kaitlin G. Clark, Wendy J. Dahl

“…Antioxidants also can help our immune system defend against bacteria, fungi, viruses, and some cancers. The body produces some of its own antioxidants, but eating a plant-based diet increases the level of antioxidants in our bodies. …”
Get full text

Urachal Tumor: A Case Report of an Extremely Rare Carcinoma by José Palla Garcia, Rita Sampaio, Carlos Peixoto

“…The urachus carcinoma is an extremely rare tumor that accounts for <1% of all bladder cancers. We report a case of a 46-year-old woman, with no past medical history, complaining of hematuria with 6-month duration and a physical exam and an abdominal computed topographic scan revealing an exophytic mass of 6.8 cm longer axis that grew depending on the anterior bladder wall, invading the anterior abdominal wall. …”
Get full text

Long Non-coding RNA: Characterizing the Locus Features by the Approaches by Mohammadreza Hajjari, Saghar Rahnama

“…HOTAIR is an lncRNA that has been known to have an oncogenic role in different cancers. There is limited knowledge of genetic and epigenetic elements and their interactions for the gene encoding HOTAIR. …”
Get full text

The Role of Bridging Therapy in Hepatocellular Carcinoma by Roberto Galuppo, Angie McCall, Roberto Gedaly

“…Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver accounting for 7% of all cancers worldwide. Most cases of HCC develop within an established background of chronic liver disease. …”
Get full text