Real-life outcome after failure to venetoclax and hypomethylating-based therapy for acute myeloid leukemia by Carlos Jiménez-Vicente, Iago Arribas, Helena Pomares, Guillermo Ramil, Sandra Castaño-Diez, Amanda Isabel Pérez-Valencia, Antonella Luciana Sturla, Mònica López-Guerra, Alexandra Martinez-Roca, Inés Zugasti, Francesca Guijarro, Albert Cortés-Bullich, Beatriz Merchán, Ana Triguero, Inés Monge, Albert Tuca, Guadalupe Oñate, Ana Garrido, Jorge Sierra, Montserrat Arnan, Jordi Esteve, Marina Díaz-Beyá, Spanish CETLAM Group

Get full text

Oxidative damage to DNA, expression of Mt-1, and activation of repair mechanisms induced by vanadium trioxide in cultures of human lymphocytes by V.A. Alcántara-Mejía, A.A. Beltrán-Flores, R.A. Mateos-Nava, L. Álvarez-Barrera, I.U. Bahena-Ocampo, E. Santiago-Osorio, E. Bonilla-González, J.J. Rodríguez-Mercado

Get full text

Posterior and Anterior Spinal Fusion for the Management of Deformities in Patients with Parkinson's Disease by Masashi Sato, Takeshi Sainoh, Sumihisa Orita, Kazuyo Yamauchi, Yasuchika Aoki, Tetsuhiro Ishikawa, Masayuki Miyagi, Hiroto Kamoda, Miyako Suzuki, Gou Kubota, Yoshihiro Sakuma, Kazuhide Inage, Yasuhiro Oikawa, Junichi Nakamura, Masashi Takaso, Gen Inoue, Tomoaki Toyone, Kazuhisa Takahashi, Seiji Ohtori

Get full text

Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma by Hongyan Sun, Cunzi Li, Zuhui Pu, Zuhui Pu, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Lan Zhou, Lan Zhou, Hongzhan Lin, Yumo Wang, Tao Zi, Lisha Mou, Lisha Mou, Ming-ming Yang

“…BackgroundUveal melanoma (UVM) is a form of eye cancer with a poor prognosis, particularly in metastatic patients. …”
Get full text

Identifying pre-diabetes ‘hotspots’ in Northern California using geospatial analysis: opportunities to target diabetes prevention strategies and improve health equity by Tannaz Moin, Luis A Rodriguez, Obidiugwu Kenrik Duru, Julie Schmittdiel, Tainayah W Thomas, Maher Yassin, Yelba Castellon-Lopez

Get full text

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Irene F. Marques, Carola Domènech-Panicello, Madelon L. Geurtsen, Thanh T. Hoang, Rebecca Richmond, Kristen Polinski, Lea Sirignano, Christian M. Page, Anne-Claire Binter, Todd Everson, Amber Burt, Michael Deuschle, Maria Gilles, Fabian Streit, Sunni L. Mumford, Per Magnus, Irwin K. M. Reiss, Marijn J. Vermeulen, Stephanie H. Witt, Inês Chaves, Edwina Yeung, Stephanie J. London, Mònica Guxens, Janine F. Felix

Get full text

Influence of Socio-Demographic, Occupational and Lifestyle Variables on Sleep Time by Dutheil F, Saint-Arroman C, Clinchamps M, Flaudias V, Fantini ML, Pereira B, Berthon M, Laporte C, Baker JS, Charkhabi M, Cocco P, Lecca R, Puligheddu M, Figorilli M, Zak M, Ugbolue UC, Ubago-Guisado E, Gracia-Marco L, Bouillon-Minois JB, Vialatte L

“…Frederic Dutheil,1,* Chloé Saint-Arroman,1,* Maëlys Clinchamps,1 Valentin Flaudias,2 Maria Livia Fantini,3 Bruno Pereira,4 Mickael Berthon,5 Catherine Laporte,6 Julien Steven Baker,7 Morteza Charkhabi,8 Pierluigi Cocco,9 Rosamaria Lecca,9 Monica Puligheddu,9 Michela Figorilli,9 Marek Zak,10 Ukadike Chris Ugbolue,11 Esther Ubago-Guisado,12 Luis Gracia-Marco,13 Jean-Baptiste Bouillon-Minois,1 Luc Vialatte14 1Université Clermont Auvergne, CNRS, Physiological and Psychosocial Stress, LaPSCo, Preventive and Occupational Medicine, University Hospital of Clermont-Ferrand, Clermont-Ferrand, F-63000, France; 2Department of Psychiatry, University Hospital of Clermont-Ferrand, University of Clermont Auvergne, Clermont-Ferrand, France; 3NPsy-Sydo, Neurology Department, University Hospital of Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France; 4Biostatistics Department, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France; 5Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne, CNRS, Clermont-Ferrand, France; 6Clermont Auvergne INP, University Hospital of Clermont-Ferrand, CNRS, Institut Pascal, Université Clermont Auvergne, Clermont-Ferrand, F-63000, France; 7Department of Sport, Physical Education and Health, Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong; 8Université Clermont Auvergne, CNRS, Physiological and Psychosocial Stress, LaPSCo, Clermont-Ferrand, France; 9Department of Medical Sciences and Public Health, Neurology Unit, University of Cagliari and AOU Cagliari, Monserrato, Cagliari, 09042, Italy; 10Collegium Medicum, Institute of Health Sciences, Jan Kochanowski University of Kielce, Kielce, Poland; 11School of Health and Life Sciences, Institute for Clinical Exercise & Health Science, University of the West of Scotland, Glasgow, UK; 12Epidemiology and Control of Chronic Diseases, CIBER of Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain; 13Epidemiology, Prevention and Cancer Control, Instituto de Investigación Biosanitaria Ibs. …”
Get full text

Evaluation of Yield and Yield Components of Different Ecotypes of Black Cumin (Nigella sativa L.) to Planting Date in Gorgan by Mohammad Sadeq Ashrafi, Farshid Ghaderi-Far, Elias Soltani, Ebrahim Zeinali, Asieh Siahmarguee

“….), often referred to as a "miracle herb," is a medicinal plant that has been used worldwide for centuries in the treatment and prevention of diseases such as cancer and diabetes. Additionally, it has been valued as a spice and flavoring agent in products like bread and sweets. …”
Get full text

Health risk assessment through probabilistic sensitivity analysis of carbon monoxide and fine particulate transportation exposure by E. Ernyasih, A. Mallongi, A. Daud, S. Palutturi, S. Stang, R. Thaha, E. Ibrahim, W. Al Madhoun

“…The results revealed that the 5th and 95th percentiles of cancer risk for carbon monoxide in adults were 2.85 and 6.11, respectively, indicating medium risks. …”
Get full text

Super‐Enhancer‐Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T‐ALL Cell Growth and Survival by Juanjuan Yu, Zimu Zhang, Yanling Chen, Jianwei Wang, Gen Li, Yanfang Tao, Yongping Zhang, Yang Yang, Chenyue Zhang, Tiandan Li, Jia Cheng, Tongtign Ji, Zhongling Wei, Wenjuan Wang, Fang Fang, Wei Jiang, Peipei Chu, Hongli Yin, Di Wu, Xiaolu Li, Xiaodong Wang, Jun‐Jie Fan, Shaoyan Hu, Zhen‐Hong Zhu, Shuiyan Wu, Jun Lu, Jian Pan

“…Abstract Super enhancers (SEs) are large clusters of transcriptional enhancers driving the expression of genes crucial for defining cell identity. In cancer, tumor‐specific SEs activate key oncogenes, leading to tumorigenesis. …”
Get full text

Differential Signature of the Centrosomal MARK4 Isoforms in Glioma by Ivana Magnani, Chiara Novielli, Laura Fontana, Silvia Tabano, Davide Rovina, Ramona F. Moroni, Dario Bauer, Stefania Mazzoleni, Elisa A. Colombo, Gabriella Tedeschi, Laura Monti, Giovanni Porta, Silvano Bosari, Carolina Frassoni, Rossella Galli, Lorenzo Bello, Lidia Larizza

“…We then investigated the MARK4L and MARK4S expression profile in 21 glioma cell lines and 36 tissues of different malignancy grades, glioblastoma-derived cancer stem cells (GBM CSCs) and mouse neural stem cells (NSCs) by real-time PCR, immunoblotting and immunohistochemistry. …”
Get full text

The fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis by Thomas J. Harr, Nikesh Gupta, Babita Rahar, Kristen Stott, Yadira Medina-Guevara, Metti K. Gari, Angie T. Oler, Ivy Sohee McDermott, Hye Jin Lee, Morteza Rasoulianboroujeni, Ashley M. Weichmann, Amir Forati, Kelsey Holbert, Trevor S. Langel, Kade W. Coulter, Brian M. Burkel, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo, Ksenija Bernau

Get full text

Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy by Yishen Tian, Jingxuan Li, Na Yang, Yang Zhao, Jiancao Zuo, Hang Xiong, Yiwen Pan, Li Xiao, Min Su, Feng Han, Zhixu He, Rong Hu

“…Experimental results demonstrated that this cellular preparation exhibited promising therapeutic effects in both melanoma and pancreatic cancer models. This research provided a novel platform for the synergistic cooperation of various methods in tumor immunotherapy, holding broad application prospects.…”
Get full text

Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade by Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, Qing‐Lei Gao

“…Here, we revealed that interleukin (IL)‐1β was among the most abundant cytokines within the in vitro tumor‐macrophage coculture system, and enhanced IL‐1β expression was associated with impaired cytotoxicity of CD8+ T cells in human ovarian cancer, indicating the possibility that IL‐1β mediated immunosuppression during tumor‐TAMs crosstalk. …”
Get full text

PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

Get full text

KDM6A facilitates Xist upregulation at the onset of X inactivation by Josephine Lin, Jinli Zhang, Li Ma, He Fang, Rui Ma, Camille Groneck, Galina N. Filippova, Xinxian Deng, Chizuru Kinoshita, Jessica E. Young, Wenxiu Ma, Christine M. Disteche, Joel B. Berletch

“…KDM6A mutations have been implicated in congenital disorders such as Kabuki Syndrome, as well as in sex differences in development and cancer. Methods Kdm6a was knocked out (KO) using CRISPR/Cas9 gene editing in hybrid female mouse embryonic stem (ES) cells derived either from a 129 × Mus castaneus (cast) cross or a BL6 x cast cross. …”
Get full text

MicroRNAs Expression Profile in MN1-Altered Astroblastoma by Francesca Gianno, Evelina Miele, Claudia Sabato, Elisabetta Ferretti, Simone Minasi, Francesca Romana Buttarelli, Debora Salerno, Natalia Pediconi, Giuseppe Rubens Pascucci, Francesca Guerrieri, Andrea Ciolfi, Simone Pizzi, Maura Massimino, Veronica Biassoni, Elisabetta Schiavello, Marco Gessi, Sofia Asioli, Angela Mastronuzzi, Antonio d’Amati, Giuseppina Catanzaro, Elisabetta Viscardi, David Capper, Felice Giangaspero, Manila Antonelli

Get full text

Use and Outcomes of Dexamethasone in the Management of Malignant Small Bowel Obstruction by Frank F. Yang, MD, Elina Serrano, MD, Kyle S. Bilodeau, MD, Michael Weykamp, MD, Caitlin J. Silvestri, MD, Ashleigh C. M. Bull, MD, Brenda Lin, MD, Sara L. Schaefer, MD, Colette Galet, PhD, Luis J. Garcia, MD, FACS, Baraka Gitonga, BS, David T. Kolodziej, BS, Samantha Esposito, BS, Molly Parker-Brigham, BS, Rohan Luhar, BS, Avinash Mamgain, MS, Kendrick C. Brown, BS, Summer Dewdney, MD, Thea P. Price, MD, FACS, Nicole Siparsky, MD, FACS, Sarah Knerr, PhD, Pauline K. Park, MD, FACS, Sabrina Sanchez, MD, FACS, Dionne A. Skeete, MD, FACS, Katherine N. Fischkoff, MD, FACS, David R. Flum, MD, FACS

“…Background:. mSBO is common in patients with advanced abdominal-pelvic cancers. Management includes prioritizing quality of life and avoiding surgical intervention when possible. …”
Get full text

Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition by Zhenying Diao, Youcheng Liang, Yong Liu, Dou Zhang, Long Qiu, Jianbo Sun, Qiaoyou Lu, Yanlei Liu, Daxiang Cui, Ting Yin

“…Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 nanomedicines. …”
Get full text

MO-GCN: A multi-omics graph convolutional network for discriminative analysis of schizophrenia by Haiyuan Wang, Runlin Peng, Yuanyuan Huang, Liqin Liang, Wei Wang, Baoyuan Zhu, Chenyang Gao, Minxin Guo, Jing Zhou, Hehua Li, Xiaobo Li, Yuping Ning, Fengchun Wu, Kai Wu

Get full text