A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors by Zarina Nidoieva, Mark O. Sabin, Tristan Dewald, Annabelle C. Weldert, Sabrina N. Hoba, Mark Helm, Fabian Barthels

“…Using this concept, a pilot screening on the cancer drug target DNMT2 discovered several hit compounds with micromolar potency.…”
Get full text

Opioids in Urology: How Well Are We Preventing Opioid Dependence and How Can We Do Better? by Danyon J. Anderson, David Y. Cao, Jessica Zhou, Matthew McDonald, Abrahim N. Razzak, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…In this article, we review the extent of opioid use in pediatric urologic procedures, vasectomy, endourologic procedures, penile implantation, urogynecologic procedures, prostatectomy, nephrectomy, cystectomy, and scrotal/testicular cancer surgery. Generally, we have found that institutions do not have a standardized protocol with a set regimen to prescribe opioids, resulting in more opioids being prescribed than needed and patients not properly disposing of their unused prescriptions. …”
Get full text

Key prognostic risk factors linked to poor functional outcomes in cerebral venous sinus thrombosis: a systematic review and meta-analysis by Lili Lin, Senfeng Liu, Wei Wang, Xiao-kuo He, Muhammad Hibatullah Romli, Ruthpackiavathy Rajen Durai

“…Conclusions Pooled effect sizes revealed that ischemic infarction, headache, neurological focal deficit, lymphopenia, and cancer were significantly associated with poor functional outcomes, with low to moderate heterogeneity. …”
Get full text

Pemodelan Kausal Faktor-Faktor Beban Keluarga dalam Merawat Pasien Kanker Menggunakan Algoritma S3C-Latent by Rizki Surtiyan Surya, Christantie Effendy, Ridho Rahmadi

“…Families who take care for cancer patients are called family caregivers. A family caregiver helps to overcome almost all problems experienced by the patients both while being treated at home and in the hospital. …”
Get full text

The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) by Shin Takasawa, Tomoko Uchiyama, Maiko Takeda

“…In particular, focusing on the digestive organs and tissues, there have been reports that they play important roles not only in stomach, colon, liver, and pancreatic duct cancer, but also in intestinal epithelial cells, especially inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC). …”
Get full text

The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy by A. A. Sheptulin

“…Prevention of peptic ulcer and stomach cancer makes eradication of H. pylori infection more and more important. …”
Get full text

Cross-ViT based benign and malignant classification of pulmonary nodules. by Qinfang Zhu, Liangyan Fei

“…The benign and malignant discrimination of pulmonary nodules plays a very important role in diagnosing the extent of lung cancer lesions. There are many methods using Convolutional neural network (CNN) for benign and malignant classification of pulmonary nodules, but traditional CNN models focus more on the local features of pulmonary nodules and lack the extraction of global features of pulmonary nodules. …”
Get full text

Mobilidade urbana, transporte e saúde na cidade do Rio de Janeiro by Daniele Batista Brandt

Get full text

Prácticas de salud y construcción del cuerpo femenino by Betina Hillesheim, Vera da Costa Somavilla, Lutiane de Lara, Gisele Dhein

“…Se presentan los datos de una investigación desarrollada en un servicio académico de salud, con mujeres que se realizaron exámenes de prevención de cáncer de útero y mama, entre mayo y diciembre del 2002. …”
Get full text

The transcriptomic footprint of Mytella strigata: de novo transcriptome assembly of a major invasive species by V. G. Vysakh, Sandhya Sukumaran, Wilson Sebastian, A. Gopalakrishnan

“…Gene Ontology and pathway analyses identified transcripts associated with key biological processes, including those associated with cell signalling, metabolism, stress responses, cancer pathways, and immune regulation. This dataset enriches the bivalve database by advancing the understanding of the adaptive success and evolutionary resilience of this invasive species. …”
Get full text

From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies by Dong Xie, Linglin Sun, Manxiang Wu, Qiang Li

“…INMs now link materials science with advanced computing and clinical innovations to enable next-generation cancer diagnostics and therapeutics.…”
Get full text

Rising incidence of recreational ketamine use: Clinical cases and management in emergency settings by Sabrina Marongiu, Maarten van Eijk, Femke M.J. Gresnigt, Esther A. Croes, Eric J.F. Franssen

Get full text

Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report by Gosselin-Rousselle Louise, Gaudimier Zoé, Pamelard Pierre-Olivier, Sader Paul, Moizan Hervé

“…Observation: An 83-year-old male with metastatic non-small cell lung cancer treated exclusively with Pembrolizumab developed osteonecrosis of the maxilla. …”
Get full text

Erectile dysfunction in male lymphoma survivors in a Southeast Asian country by Gin Gin Gan, Diana Leh Ching Ng, Yuen Chwan Leong

“…The Hospital Anxiety and Depression Score questionnaire was used to assess for anxiety and depression, and quality of life was assessed using the European Organization for Research and Treatment of Cancer quality of life questionnaire. Results: Overall, 106 patients were recruited. …”
Get full text

HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses. by Jiwon Yu, Junha Cha, Geon Koh, Insuk Lee

“…Additionally, they suggest that many lung cancer-related genes may exert their roles in immune cells. …”
Get full text

Design and Analysis of thermosyphon Solar Water Heating System. by Kakuru, Stephen

“…In rural areas of Uganda, access to affordable hot water is a persistent challenge with communities often relying on firewood and charcoal for water heating which contributes to deforestation, air pollution, and health hazards hence respiratory diseases like asthma, lung cancer, TB, and allergic disease, climate changes and global warming. …”
Get full text

Mental Health in Non-Oncologic Urology Patients by Danyon Anderson, Devesh Kumar, Divya Divya, Jose L. Zepeda, Abrahim N. Razzak, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…While there has been great interventional focus as of late for urogenitary malignancies (i.e. prostate cancer awareness with the Movember campaign), literature studies and intervention focused on non-oncologic urology patients has been limited. …”
Get full text

A case of spindle cell squamous cell carcinoma of the tongue complicated by verrucous carcinoma by Yusuke Matsuzaki, Daiki Saito, Saimon Yasuhara, Yukio Watabe, Shiro Shigematsu

“…We report herein a highly unusual case of spindle cell squamous cell carcinoma (SCSCC), a rare form of oral cancer, co-occurring with verrucous carcinoma. The patient, a 57-year-old male, presented with a tongue lesion with macroscopic features resembling those of a cancerous ulcer and verrucous carcinoma. …”
Get full text

In-silico tool based on Boolean networks and meshless simulations for prediction of reaction and transport mechanisms in the systemic administration of chemotherapeutic drugs. by Fabián Mauricio Vélez Salazar, Iván David Patiño

“…Subsequently, a Boolean model is developed to determine the presence, interaction and rates of RTMs based on the comparison of the spatio-temporal evolution of the drug concentration ratios, being this the main contribution of the present work to the comprehension of the phenomena involved in the systemic administration of chemotherapeutic drugs in cancer tumors. Different combinations of E (0 kV/m, 46 kV/m, 70 kV/m), λinl (1x10-4m/s, 1x10-3m/s, 1x10-2m/s) and PK (One-short tri-exponential, mono-exponential) are examined. …”
Get full text

Contemporary Approaches to the Treatment of Gastroesophageal Reflux Disease by Boris D. Starostin

“…In the presence of Barrett’s esophagus, this measure is considered from the standpoint of cancer prevention.Conclusion. The use of PPIs is considered to be the key approach in the drug treatment of GERD. …”
Get full text