Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells by Jingwei Liu, Jingwei Liu, Tong Shu, Yiheng Mu, Wanlin Zheng, Xiaohuan Lu, Xiaohuan Lu, Hong Tao, Hong Tao

“…The expression of these inflammatory factors effectively promotes the migration and differentiation of T cells to the site of infection, completing the clearance of infected epithelial cells.ConclusionThe main components of Baofukang suppository, curdione and borneol, inhibit the progression of HPV infection and the occurrence of cervical cancer by modulating the communication between innate and adaptive immunity, promoting the recruitment and recognition of CD8+ T cells to eliminate HPV-infected epithelial cells.…”
Get full text

Formulation of Hydrogel Beads to Improve the Bioaccessibility of Bioactive Compounds from Goldenberry and Purple Passion Fruit and Evaluation of Their Antiproliferative Effects on... by Ana María Naranjo-Durán, Diego Miedes, Juan Manuel Patiño-Osorio, Antonio Cilla, Amparo Alegría, Catalina Marín-Echeverri, Julián Quintero-Quiroz, Gelmy Luz Ciro-Gómez

“…Goldenberry and purple passion fruit contain bioactive compounds (BCs) that can prevent gastrointestinal cancers; hydrogel beads can protect and control their release in the gastrointestinal tract. …”
Get full text

Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…This syndrome may develop primarily, due to various pancreatic diseases (chronic pancreatitis, pancreatic cancer, cystic fibrosis etc.), and secondarily, at impaired stimulation of pancreatic secretion or impairment of conditions, necessary for the normal action of pancreatic enzymes. …”
Get full text

Genetic polymorphism of CYP1A1 and CYP2D6 in populations of Buryats, Teleuts and Russians of Eastern Siberia by L. E. Tabikhanova, L. P. Osipova, T. V. Churkina, E. N. Voronina, M. L. Filipenko

“…The obtained data makes it possible to predict a reduced risk of side effects of drugs and cancer associated with CYP2D6*3 (2549del) and CYP2D6*4 (1846A) in the Buryat and Teleut populations. …”
Get full text

Unveiling the role of lncRNA ERDR1 in immune cell regulation by Aihua Shu, Xu Tian, Jie Yue, Yuxia Jiang, Yifei Liu

“…Furthermore, Erdr1 has been implicated in the mitigation of several diseases, including acne, wound healing, osteoarthritis, melanoma, gastric cancer, obesity, and autism. Given its complex biological functions and mechanisms, Erdr1 presents itself as a promising biomarker and a potential therapeutic target for a range of immune cell-related disorders.…”
Get full text

Snack products from whole-grain red sorghum flour with paprika and cocoa powders by Janić-Hajnal Elizabet, Banjac Vojislav, Filipčev Bojana, Radić Bojana, Kos Jovana, Šimurina Olivera, Cvetković Biljana

“…Given its many health benefits, including its ability to suppress the formation of cancer cells and reduce obesity, heart disease, and diabetes, sorghum is used for both human and animal consumption. …”
Get full text

Ellagic acid ameliorates cisplatin-induced acute kidney injury by regulating inflammation and SIRT6/TNF-α signaling by Yuqi Gao, Kezheng Peng, Yida Wang, Yannan Guo, Chenye Zeng, Rui Hua, Qingfei Liu, Xue Li, Ying Qiu, Zhao Wang

“…Despite cisplatin has been widely used in the treatment of various cancers, the noteworthy nephrotoxicity greatly constrained its clinical value. …”
Get full text

Cultural adaptation of ENABLE (Educate, Nurture, Advise, Before Life Ends) an early palliative care model for Iranian patients with heart failure and their caregivers: a qualitativ... by Arvin Mirshahi, Ali Khanipour-Kencha, Marie Bakitas, J. Nicholas Odom, Rachel Wells, Arpi Manookian

“…Abstract Background ENABLE (Educate, Nurture, Advise, Before Life Ends) is a model of nurse-led, early palliative care that was originally developed for U.S. patients with advanced cancer and their family caregivers and then adapted for patients with heart failure. …”
Get full text

Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma by Yuli Zhang, Dinggui Chen, Miaomiao Yang, Xianfeng Qian, Chunmei Long, Zhongwei Zheng

“…The lncRNA, miRNA, and mRNA expression datasets were obtained from Gene Expression Omnibus and The Cancer Genome Atlas. Based on miRanda and TargetScan, the HCC-specific ceRNA network was constructed to illustrate the coexpression regulatory relationship of lncRNAs, miRNAs, and mRNAs. …”
Get full text

Asociación entre dependencia funcional y calidad de vida en pacientes adultos mayores oncológicos by Graciela Cardenas, Kevin Flores-Lovon, Katherine Perez-Acuña, Ericson L. Gutierrez, Fernando M. Runzer-Colmenares, Jose F. Parodi

“…Introducción: La presencia de comorbilidades modula el proceso de envejecimiento, el diagnóstico de cáncer puede comprometer de manera importante la salud del adulto mayor, lo cual repercute en su calidad de vida. …”
Get full text

Conjugates of Phthalocyanines With Oligonucleotides as Reagents for Sensitized or Catalytic DNA Modification

“…These results suggest the possible use of phthalocyanine-oligonucleotide conjugates as novel artificial regulators of gene expression and therapeutic agents for treatment of cancer.</p>…”
Get full text

Internal Dosimetry in Patients Undergoing Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-[DOTA0-Tyr3] Octerotate: A Single-Center Experience by Elahe Mahmoudi, Mahasti Amoui, Mohammad Reza Deevband, Elahe Pirayesh, Mohammad Reza Asgari, Mehdi Ghorbani

“…Conclusion: Based on the results, PRRT therapy is a safe method for the treatment of castration-resistant neuroendocrine cancer patients in terms of patient dose. Large inter-individual differences in organ dose were discovered, highlighting the importance of patient-specific dosimetry and treatment planning in the treatment with 177Lu-DOTATATE. …”
Get full text

Preoperative prediction of pituitary neuroendocrine tumor invasion using multiparametric MRI radiomics by Qiuyuan Yang, Tengfei Ke, Jialei Wu, Yubo Wang, Jiageng Li, Yimin He, Jianxian Yang, Nan Xu, Bin Yang

Get full text

Recruiting participants for focus groups in health research: a meta-research study by Jonas Lander, Simon Wallraf, Dawid Pieper, Ronny Klawunn, Hala Altawil, Marie-Luise Dierks, Cosima John

“…Results Nearly half (n = 38/80) of the studies were from the USA and Canada, many addressing issues related to diabetes, cancer, mental health and chronic diseases. For recruitment planning, 20% reported a specific sampling target, while 6% used existing studies or literature for organisational and content planning. …”
Get full text

Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients by Ying Yang, Ying Yang, Zhijun Ye, Zhijun Ye, Yifei Zhao, Yifei Zhao, Zhengyu Li, Zhengyu Li

“…CSI was associated with cancer antigen 125, myometrial invasion, adnexal invasion, parametrial invasion, lymph node metastasis, and progesterone receptor.ConclusionsMRI is relatively superior in assessing CSI, although diagnostic authenticity and consistency were unsatisfactory. …”
Get full text

A bioinformatics approach for identifying the probable cause of the cross-interaction of antibodies to the antigenic protein HPV16 L1 with the HPV6 L1 protein by A. S. Stolbikov, R. K. Salyaev, N. I. Rekoslavskaya

“…In this work, the amino acid sequences of HPV16 L1 and HPV6 L1 used for the development of a binary vaccine against cervical cancer and anogenital papillomatosis have been analyzed. …”
Get full text

Sugemule-7 alleviates oxidative stress, neuroinflammation, and cell death, promoting synaptic plasticity recovery in mice with postpartum depression by Qiang Fu, Rui Qiu, Jiaquan Liang, Shuai Wu, Dezhi Huang, Yuxiang Qin, Qiaosheng Li, Xiaojie Shi, Xiyue Xiong, Zhongyong Jiang, Yuewen Chen, Yong Cheng

Get full text

Smoking habits, awareness and support needs for cessation among people with multiple sclerosis in Australia: findings from an online survey by Roshan das Nair, Ron Borland, Claudia H Marck, Isabelle Weld-Blundell, Lisa Grech, Sarah L White

Get full text

Evaluation of a strategy for tumor-initiating stem cell eradication in primary human glioblastoma cultures as a model by E. V. Dolgova, A. S. Proskurina, E. A. Potter, T. V. Tyrinova, O. S. Taranov, Ya. R. Efremov, K. E. Orishchenko, S. V. Mishinov, V. V. Stupak, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…The effectiveness of a new therapeutic approach aimed at destroying the cancer cell community was evaluated on the primary cell lines of human glioblastoma culture by employing a new strategy of tumor-initiating stem cell synchronization and a domestic strategy of their eradication "3+1". …”
Get full text

Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…For both groups, most conditions were more prevalent in more deprived areas, whereas for the SMI group conditions such as hypothyroidism, chronic kidney disease and cancer were more prevalent in more affluent areas.Conclusions Our findings highlight the health inequalities faced by people with SMI. …”
Get full text