Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients by Yulu Gu, Xiaoli Liu, Yaqin Yu, Jieping Shi, Lizhe Ai, Hui Sun, Joseph Sam Kanu, Chong Wang, Yawen Liu

“…The incidence rate of papillary thyroid cancer (PTC) has increased for several decades and is higher in females than males. …”
Get full text

Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study by Akihito Hishikawa, Erina Sugita Nishimura, Norifumi Yoshimoto, Ran Nakamichi, Eriko Yoshida Hama, Wataru Ito, Tomomi Maruki, Kengo Nagashima, Ryoko Shimizu-Hirota, Hiromasa Takaishi, Hiroshi Itoh, Kaori Hayashi

“…While extensive research has explored the association of the DNA methylation clock with cardiovascular diseases, cancer, and Alzheimer's disease, its relationship with kidney diseases remains largely unexplored. …”
Get full text

Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy by Khurram Shahzad, Martin Cadeiras, Sarfaraz Memon, Barry Zeeberg, Tod Klingler, Anshu Sinha, Esteban G. Tabak, Sreevalsa Unniachan, Mario C. Deng

Get full text

Standard operating procedure combined with comprehensive quality control system for multiple LC-MS platforms urinary proteomics by Xiang Liu, Haidan Sun, Xinhang Hou, Jiameng Sun, Min Tang, Yong-Biao Zhang, Yongqian Zhang, Wei Sun, Chao Liu, Urine Test Sample Working Group

“…Furthermore, we apply this SOP to hybrid benchmarking samples and clinical colorectal cancer (CRC) urinary proteome including 527 experiments. …”
Get full text

Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months by Brenda Asiimwe-Kateera, Nienke Veldhuijzen, Jean Paul Balinda, John Rusine, Sally Eagle, Joseph Vyankandondera, Julie Mugabekazi, Pascale Ondoa, Kimberly Boer, Anita Asiimwe, Joep Lange, Peter Reiss, Janneke van de Wijgert

“…We applaud the Rwandan government for having strengthened family planning and PMTCT services and for having introduced HPV vaccination in recent years, but additional work is needed to strengthen STI and HPV-related cancer screening and management in the HIV-positive population.…”
Get full text

The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family by Deyong Ge, Xinyu Xu, Liyi Fang, Huihui Tao

“…These results also highlighted significant expression differences of the manganese ion metabolism family across various cancers, including BLCA, BRCA, and COAD, with notable NUDT3 mutations enriched in these cancers. …”
Get full text

Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway by Shan Xiao, Ye Yang, Yue-Tong Liu, Jun Zhu

Get full text

Environmental burden of disease resulting from long-term nitrogen dioxide exposure in Germany by Paulina Sell, Dietrich Plass, Sarah Kienzler, Hajo Zeeb

“…We first conducted a systematic literature review to identify exposure–response functions (ERFs) which mathematically represent the association between NO2 exposure and the health outcomes: asthma, chronic obstructive pulmonary disease (COPD), type 2 diabetes mellitus (T2DM), ischemic heart disease, lung cancer, stroke, and cardiovascular and respiratory mortality. …”
Get full text

Patterns of Comorbidity and Multimorbidity Among Patients With Multiple Sclerosis in a Large US Commercially Insured and Medicare Advantage Population by Dingwei Dai, Ajay Sharma, Amy L. Phillips, Carroline Lobo

“…Age-related and other comorbidities (ie, hypertension, hyperlipidemia, dyspepsia, osteoarthritis, osteoporosis, glaucoma, diabetes, cerebrovascular, cancer) were more common among patients 65 years and older Medicare Advantage (all _P_ < .0001). …”
Get full text

Deep Learning-Enabled Integration of Histology and Transcriptomics for Tissue Spatial Profile Analysis by Yongxin Ge, Jiake Leng, Ziyang Tang, Kanran Wang, Kaicheng U, Sophia Meixuan Zhang, Sen Han, Yiyan Zhang, Jinxi Xiang, Sen Yang, Xiang Liu, Yi Song, Xiyue Wang, Yuchen Li, Junhan Zhao

“…Validated with datasets from human lung, breast, and colorectal cancers, GIST effectively reveals spatial domains and substantially improves the accuracy of segmenting the microenvironment after denoising transcriptomics data. …”
Get full text

Silymarin as a Therapeutic Agent for Hepatocellular Carcinoma: A Multi-Approach Computational Study by Ouided Benslama, Sabrina Lekmine, Hamza Moussa, Hichem Tahraoui, Mohammad Shamsul Ola, Jie Zhang, Abdeltif Amrane

“…Background: Hepatocellular carcinoma (HCC) is a prevalent and lethal form of liver cancer with limited treatment options. Silymarin, a flavonoid complex derived from milk thistle, has shown promise in liver disease treatment due to its antioxidant, anti-inflammatory, and anticancer properties. …”
Get full text

Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences by Muriel Javier, Escorial Mónica, Margarit César, Barrachina Jordi, Carvajal Cristian, Morales Domingo, Peiró Ana M.

“…More than half of patients with opioid use disorder for chronic non-cancer pain (CNCP) reduced their dose through a progressive opioid withdrawal supported by a rotation to buprenorphine and/or tramadol. …”
Get full text

Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster by Yasaman Heidarian, Tess D. Fasteen, Liam Mungcal, Kasun Buddika, Nader H. Mahmoudzadeh, Travis Nemkov, Angelo D'Alessandro, Jason M. Tennessen

Get full text

Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. Recently, we developed a novel Ir(III)-based compound, [Ir(Cp∗)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF4 or Ir-6 and assessed its effectiveness as an antiplatelet drug. …”
Get full text

Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice by Takefumi Kimura, Takero Nakajima, Yuji Kamijo, Naoki Tanaka, Lixuan Wang, Atsushi Hara, Eiko Sugiyama, Eiji Tanaka, Frank J. Gonzalez, Toshifumi Aoyama

Get full text

High levels of soluble P-selectin, neutrophil extracellular traps, and myeloperoxidase as risk factor of deep vein thrombosis in malignancy patients receiving platinum-based chemot... by Ketut Suega, I Made Bakta, Ni Made Renny Anggreni Rena

“…VTE events increase the mortality rate of patients with cancer receiving platinum-based chemotherapy. Soluble P-Selectin, Neutrophil Extracellular Traps (NET), and myeloperoxidase (MPO) are risk factors associated with DVT in malignancy patients receiving platinum-based chemotherapy. …”
Get full text

Demographic and motivational factors affecting the whole-body donation programme in Nanjing, China: a cross-sectional survey by Li Yuan, Jiayi Jiang, Mingyi Zhang, Haojie Meng, Xiang Cui, Yuxin Yang, Chuan Su, Jinfan Wang, Luqing Zhang

“…Donors with an education level of college or above accounted for nearly half of the deceased donors, and considered donating their bodies earlier in their lives than others. Cancer and heart disease were the major causes of death among donors. …”
Get full text

Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…Methods Single-cell RNA sequencing (scRNA-seq) data were downloaded from t the Tumor Immune Single-cell Hub and gene expression data were retrieved from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database. …”
Get full text

Weakly supervised deep learning-based classification for histopathology of gliomas: a single center experience by Mingrong Zuo, Xiang Xing, Linmao Zheng, Hao Wang, Yunbo Yuan, Siliang Chen, Tianping Yu, ShuXin Zhang, Yuan Yang, Qing Mao, Yongbin Yu, Ni Chen, Yanhui Liu

“…We analyzed 472 whole slide images (WSIs) from 226 patients in West China Hospital (WCH) and 1604 WSIs from 880 patients in The Cancer Genome Atlas (TCGA). We utilized the OpenSlide library to load WSIs, segmented them into small patches using the DeepZoom module, and then normalized the color using the Reinhard method. …”
Get full text

A Novel Mutation in the CYP11B1 Gene Causes Steroid 11β-Hydroxylase Deficient Congenital Adrenal Hyperplasia with Reversible Cardiomyopathy by Mohammad A. Alqahtani, Ayed A. Shati, Minjing Zou, Ali M. Alsuheel, Abdullah A. Alhayani, Saleh M. Al-Qahtani, Hessa M. Gilban, Brain F. Meyer, Yufei Shi

“…Interestingly, a somatic mutation at the same codon (c.779 G>A, p.W260∗) was reported in a patient with papillary thyroid cancer (COSMIC database). In conclusion, we have identified a novel nonsense mutation in the CYP11B1 gene that causes classic steroid 11β-hydroxylase deficient CAH. …”
Get full text