In vitro effect of hCG on cryptorchid patients’ gubernacular cells: a predictive model for adjuvant personalized therapy by Andrea Errico, Giulia Ambrosini, Sara Vinco, Emanuela Bottani, Elisa Dalla Pozza, Nunzio Marroncelli, Jessica Brandi, Daniela Cecconi, Ilaria Decimo, Filippo Migliorini, Nicola Zampieri, Ilaria Dando

“…Abstract Background Cryptorchidism is the absence of one or both testicles in the scrotum at birth, being a risk factor for testis cancer and infertility. The most effective method to treat cryptorchidism is orchiopexy, followed by human chorionic gonadotropin (hCG) therapy; however, a portion of treated patients do not show a significant improvement in testis volume and vascularization after adjuvant therapy. …”
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Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development by Corina Toma, Roxana Popa, Lidia Ciobanu, Ioana Baldea, Irina Amorim, Diana Bochynska, Alan Wolfe, Andrada Negoescu, Claudiu Gal, Marian Taulescu

“…Abstract Background Ovine pulmonary adenocarcinoma (OPA) is caused by Jaagsiekte sheep retrovirus (JSRV) and is considered an important potential animal model for human lung cancer. The precise mechanisms of OPA oncogenesis are still uncertain. …”
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نقش حمایت اجتماعی بر کیفیت زندگی در بیماران مبتلا به سرطان پستان: مرور نظام‌مند by وحید نهتانی, نوشین پیمان

“…کلمات کلیدی مرتبط "Breast Cancer" AND "Social Support" AND "Quality Of Life" بود. …”
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Mortality Predictive Value of APACHE II and SOFA Scores in COVID-19 Patients in the Intensive Care Unit by Mohammad Taghi Beigmohammadi, Laya Amoozadeh, Forough Rezaei Motlagh, Mojgan Rahimi, Maziar Maghsoudloo, Behzad Jafarnejad, Babak Eslami, Mohammad Reza Salehi, Kazem Zendehdel

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Daily versus three-times-weekly azithromycin in Chinese patients with non-cystic fibrosis bronchiectasis: protocol for a prospective, open-label and randomised controlled trial by Jing Li, Fei Chen, Wei Xiao, Feng Li, Lan Chen, Ting He, Yanxiong Mao, Aiping Zou, Bo Fan, Weihao Ni, Huimin You, Wenjiang Fu

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Development and validation of a prediction model for all-cause mortality in maintenance dialysis patients: a multicenter retrospective cohort study by Jingcan Wu, Xuehong Li, Hong Zhang, Lin Lin, Man Li, Gangyi Chen, Cheng Wang

“…The discrimination and accuracy of the prediction model were assessed using C-indexes and calibration curves, while the clinical value was assessed by decision curve analysis (DCA).Results The best predictors of 1-, 3-, and 5-year all-cause mortality contained nine independent factors, including age, body mass index (BMI), diabetes mellitus (DM), cardiovascular disease (CVD), cancer, urine volume, hemoglobin (HGB), albumin (ALB), and pleural effusion (PE). …”
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Trace metals potential human health risks assessment through consuming common food spices in Ado Ekiti, Southwest, Nigeria by J.A. Olusola, O.B. Akintan, O. Osanyinlusi

“…The assessment involved various methods such as Estimation of Daily Intake (EDI), Hazard Quotient (THQ), Total Hazard Quotient (TTHQ), and Cancer Risk (CR). Results: The results indicated that iron (Fe) levels varied from 0.62 mg/kg in dry onion to 210.40 mg/kg in turmeric, with an average concentration of 45.09±59.83 mg/kg. …”
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Ewing sarcoma – pathomechanisms, standard treatment and new therapeutic perspectives by Wojciech Zezuliński, Filip Woliński, Julia Zyśk, Mateusz Korga, Jakub Klas, Jacek Baj, Eliasz Dzierżyński

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Demographic Correlates of Infant Feeding Practices and Growth Performance in the First Year of Life by Leila M. Shinn, Christy C. Tangney, Caitlyn Busche, Christine M. Sharp, Mary C. Mullen

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Enhancing oncology patient care: nurses’ knowledge, attitudes, and perceived benefits of early palliative integration - a cross-sectional study by Mohammed F. Hayek, Bahaaeddin M. Hammad, Faeda A. Eqtait, Ahmad Ayed, Basma Salameh, Nizar B. Said, Rasha S. Abu Zaitoun, Shurouq G. Qadous

“…Early referral to palliative care improves patient outcomes, quality of life and overall survival in a variety type of cancers. This study aimed to assess knowledge, attitudes and perceived benefits of early integration of palliative care among oncology nursing. …”
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Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…The antibody 9D9, which binds mouse CTLA-4, is a commonly used surrogate for CTLA-4 checkpoint blockade studies in mouse cancer models. In this work, we reveal that 9D9 has significant biophysical dissimilarities to therapeutic CTLA-4 antibodies. …”
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PRMT5 Inhibitor EPZ015666 Decreases the Viability and Encystment of <i>Entamoeba invadens</i> by Rigoberto Ortiz-Hernández, Elmer Joel Millán-Casarrubias, Jeni Bolaños, Susana Munguía-Robledo, Carlos Vázquez-Calzada, Elisa Azuara-Licéaga, Jesús Valdés, Mario Alberto Rodríguez

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Diagnostic cholangioscopy for surgical planning of extrahepatic cholangiocarcinoma by Min Je Sung, Suk Pyo Shin, Chang-Il Kwon, Incheon Kang, Sung Hwan Lee, Seok Jeong Yang, Beodeul Kang, Hong Jae Chon, Gwangil Kim, Chansik An, Kwang Hyun Ko

“…Abstract The recent clinical outcomes of multi-regimen chemotherapy included prolonged survival and a high rate of conversion to surgery in Asian patients with advanced biliary tract cancer. The ability of single-operator cholangioscopy (SOC) to detect and stage extrahepatic cholangiocarcinoma (CCC) in intraductal lesions is becoming more important in determining the extent of surgery. …”
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Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis by Hanqing Chen, Yundi Guo, Jing Sun, Jun Dong, Qinghua Bao, Xueguang Zhang, Fengqing Fu

“…B7 homologue 6 (B7-H6), a newly identified member of the B7 costimulatory molecule family, is not only a crucial regulator of NK cell-mediated immune responses through binding to NKp30 but also has clinical implications due to its abnormal expression in human cancers. Here, we show that B7-H6 expression is abnormally upregulated in glioma tissue and that B7-H6 is coexpressed with stem cell marker Sox2. …”
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Association between transarterial chemoembolization refractoriness and prognosis in Chinese patients with hepatocellular carcinoma: a large retrospective cohort study by Qinxue Sun, Ziliang Wu, Xi Yin, Feng Li, Ri Liu

“…The Chinese College of Interventionalists (CCI) proposed a tailored definition, but its impact on HCC prognosis is still limited.MethodsThis study included 844 patients with Barcelona Clinic Liver Cancer (BCLC) stage B HCC from a multicenter dataset. …”
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DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis by Mi Zou, Zuxi Feng, Kaibo Hu, Yuan Shu, Ting Li, Xiaogang Peng, Leifeng Chen, Leyang Xiao, Shouhua Zhang, Ting Xiong, Xueqiang Deng, Jie Peng, Liang Hao

“…Furthermore, our analysis identified potential small molecules that could target DCLRE1B in different cancer types. The DCLRE1B gene may be involved in the development and occurrence of a variety of cancers. …”
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Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia by Shutaro Shibata, Moeko Noguchi-Shinohara, Ayano Shima, Taro Ozaki, Yuta Usui, Yasuyuki Taki, Kazuhiro Uchida, Takanori Honda, Jun Hata, Tomoyuki Ohara, Tatsuya Mikami, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Kenjiro Ono, On behalf of the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group

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Trends in the incidence of the Epstein-Barr virus-associated malignancies extranodal NK/T-cell lymphoma and nasopharyngeal carcinoma in Taiwan. by Shyh-An Yeh, Liang-Chun Chiu, Hsin-Chieh Lin, Hung-Ju Li, Sheng-Fung Lin, Yu-Chieh Su

“…To assess the incidence of ENKTL from 2008 to 2021 and NPC from 1995 to 2021, an epidemiological study was performed using population-based registry data from the Taiwan Cancer Registry. The secular trends in the annual incidence rates were expressed as average annual percent change (AAPC). …”
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Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs by Abubakar Danmaigoro, Gayathri Thevi Selvarajah, Mohd Hezmee Mohd Noor, Rozi Mahmud, Md Zuki Abu Bakar

“…This finding offers opportunity to dogs with cancer that might require long-term administration of DOX without adverse effects.…”
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Current Trends in Mortality Attributable to Racial or Ethnic Disparities in Post-Surgical Population in The United States: A Population-Based Study by Christian Mpody, MD, PhD, MPH, MBA, Ana F. Best, PhD, Clara N. Lee, MD, MPP, David L. Stahl, MD, Vidya T. Raman, MD, MBA, Richard D. Urman, MD, MBA, Joseph D. Tobias, MD, Olubukola O. Nafiu, MD, FRCA, MS

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