Tumor Microenvironment‐Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression by Mengna Wang, Yuhong Liu, Yanshi Li, Tao Lu, Min Wang, Zhaobo Cheng, Lin Chen, Tongling Wen, Min Pan, Guohua Hu

“…Mechanistically, HMP1G NPs downregulated tumor cell‐derived IDO1 via the aryl hydrocarbon receptor/signal transducer and activator of transcription 3/interleukin signaling axis to improve kynurenine/tryptophan metabolism and immunosuppression. In a murine breast cancer model, treatment with HMP1G NPs elicited effective antitumor immunity and enhanced survival outcomes. …”
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Consumo alimentar de pacientes oncológicos: onde estão as inadequações? by Simone dos Anjos Caivano, Amanda Cristina Torralbo Pugliesi, Semíramis Martins Álvares Domene, Fabiola Pansani Maniglia

“…Introdução: Os hábitos alimentares podem influenciar diretamente no estado de saúde do indivíduo, e modulam o risco para doenças crônicas não transmissíveis, como o câncer. Objetivo: Avaliar a qualidade da dieta de indivíduos em tratamento oncológico. …”
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Population- and Gender-Based Investigation for Prevalence of Helicobacter pylori in Dhamar, Yemen by Dhary A. Almashhadany, Sara M. Mayas, Hero I. Mohammed, Abdulwahed A. Hassan, Izhar U. H. Khan

“…Among 35 species of genus Helicobacter, H. pylori is the most common causative agent of human gastritis, peptic ulcer, and gastric cancer. The infection can spread through direct human-to-human contact, fecal–oral route, and contaminated water. …”
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Gliomas Difusos do Adulto: Prevalência da Mutação IDH1 em um Hospital Universitário by Vitor Bonk Rizzo, Michelle Arrata Ramos, Eduardo Morais de Castro, Pedro Helo dos Santos Neto, Samya Hamad Mehanna

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Novel methods for the detection of glutathione by surface-enhanced Raman scattering: A perspective review by Mohammad Kamal Hossain, Genin Gary Huang, Mohammad Mozahar Hossain

“…Higher glutathione levels have been seen in several cancer cell types, which may increase their resistance to radiation and chemotherapy. …”
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Hypersensitive intercellular responses of endometrial stromal cells drive invasion in endometriosis by Chun-Wei Chen, Jeffery B Chavez, Ritikaa Kumar, Virginia Arlene Go, Ahvani Pant, Anushka Jain, Srikanth R Polusani, Matthew J Hart, Randal D Robinson, Maria Gaczynska, Pawel Osmulski, Nameer B Kirma, Bruce J Nicholson

“…The most broadly accepted etiology is that uterine endometrial cells retrogradely enter the peritoneum during menses, and implant and form invasive lesions in a process analogous to cancer metastasis. However, over 90% of women suffer retrograde menstruation, but only 10% develop endometriosis, and debate continues as to whether the underlying defect is endometrial or peritoneal. …”
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Cáncer y depresión en adultos mayores by Raúl Villanueva-Salazar, Adriana Díaz-Baquerizo, Ana L. Tintaya-Pelaes, Cielo A. Estela-Fernández, José F. Parodi, Fernando Runzer-Colmenares

“…La población fue constituida por varones de 60 años o más con cáncer. Se analizó la depresión como factor de riesgo en la presentación de reacciones adversas al tratamiento oncológico Resultados: El 24.62% (n = 277) presentó reacciones adversas al tratamiento. …”
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Beneficial Effects of <i>In Vitro</i> Reconstructed Human Gut Microbiota by Ginseng Extract Fermentation on Intestinal Cell Lines by Margherita Finazzi, Federica Bovio, Matilde Forcella, Marina Lasagni, Paola Fusi, Patrizia Di Gennaro

“…Among the natural compounds that we can introduce by the diet, <i>Panax ginseng</i> extract is one of the most utilized since it contains a vast number of bioactive molecules such as phenolic acids, flavonoids, and polysaccharides that have been shown to possess antioxidant, anti-ageing, anti-cancer, and immunomodulatory activity. In this work, the ability of a <i>P. ginseng</i> extract in combination with a probiotic formulation was taken into consideration to evaluate its effects on the modulation of <i>in vitro</i> reconstructed human gut microbiota (HGM). …”
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Population Health Management to identify and characterise ongoing health need for high-risk individuals shielded from COVID-19: a cross-sectional cohort study by Adrian Pratt, Richard Wood, Charlie Kenward, Sam Creavin, Jennifer A Cooper

“…Segmentation uncovered six distinct clusters comprising the high-risk population, with key differentiation based on age and the presence of cancer, respiratory, and mental health conditions.Conclusions PHM methods are useful in characterising the needs of individuals requiring shielding. …”
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TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity by Shuting Wu, Rong Xiang, Yiwei Zhong, Shushu Zhao, Zhiyu Zhang, Zhihua Kou, Shijie Zhang, Yi Zhao, Cheng Zu, Gan Zhao, Yanling Xiao, Sulin Ren, Xiaoming Gao, Bin Wang

“…Abstract In situ vaccination (ISV) triggers antitumor immune responses using the patient’s own cancer antigens, yet limited neoantigen release hampers its efficacy. …”
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Analysis of Factors Related to Pulmonary Nodules in Patients With Fatty Liver: A Large-Scale Cohort Study Based on a Physical Examination Population by Qin Y, Huang X, Lin J, Pan L, Liang Q, Li W

“…Multifactorial logistic regression analysis showed that male gender, body weight, age, and diastolic blood pressure were significant factors influencing lung nodule development in fatty liver patients.Conclusion: Fatty liver disease is independently associated with an increased incidence of pulmonary nodules, highlighting its importance in lung cancer screening and prevention.Keywords: pulmonary nodules, fatty liver, health checkup, influencing factors, retrospective cohort study…”
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [99mTc]Tc-labeled counterparts be used to estimate dosimetry? by Panagiotis Kanellopoulos, Quanyi Yu, Abouzayed Abouzayed, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova

“…Abstract Background Gastrin releasing peptide receptor (GRPR)-directed radiopharmaceuticals for targeted radionuclide therapy may be a very promising addition in prostate and breast cancer patient management. Aiming to provide a GRPR-targeting theranostic pair, we have utilized the Tc-99m/Re-188 radiometal pair, in combination with two bombesin based antagonists, maSSS-PEG2-RM26 and maSES-PEG2-RM26. …”
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Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection by Trever T. Greene, Yeara Jo, Carolina Chiale, Monica Macal, Ziyan Fang, Fawziyah S. Khatri, Alicia L. Codrington, Katelynn R. Kazane, Elizabeth Akbulut, Shobha Swaminathan, Yu Fujita, Patricia Fitzgerald-Bocarsly, Thekla Cordes, Christian Metallo, David A. Scott, Elina I. Zúñiga

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Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels by Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski

“…Elevated HuR levels are associated with multiple disorders, including cancer and neurodegenerative diseases. Despite the identification of small molecule inhibitors targeting HuR, their detailed characterization remains limited. …”
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Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connecti... by Paola Cordiali-Fei, Anna Mussi, Giovanna D'Agosto, Elisabetta Trento, Valentina Bordignon, Silvana Trincone, Antonella Vento, Isabella Sperduti, Antonio Cristaudo, Fabrizio Ensoli

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Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment effic... by Nakaba Okamura, Ayano Katagiri, Tomoya Komori, Kei Kawanabe, Hirofumi Koike, Yukiko Sahashi, Rie Kubota

“…To assess treatment efficacy, we used non-inferiority analysis with propensity score matching based on age, sex, body mass index, cancer status, and baseline blood test results. The treatment outcomes were evaluated using predefined clinical indicators. …”
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Green synthesis of Au-Pt bimetallic nanoparticels using Croton caudatus Geisel leaf extract and their biological studies by P.Vijaya Kumar, K.S. Pushpavalli, Baskaran Ganesh Kumar, S.Mary Jelastin Kala, K.S. Prakash

“…It has been found that biological studies exploring in vitro antibacterial, in vitro antifungal, and anti-cancerous activity showed significant implications. …”
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Prevalence and characteristics of HPV vaccine hesitancy among parents of adolescent females across Saudi Arabia by Sahar Othman, Ranya Ghamri, Wala Alhamadah, Anwaar Alsatty, Dhuha Khesfaty, Ohoud Alghamdi, Ragad Arbaein, Alaa M. Baglagel, Jumana Khayyat, Bushra Almalki

“…PurposeVaccination against human papillomavirus (HPV) is pivotal in preventing HPV-related diseases, including cervical cancer. However, vaccine hesitancy and their related factors among parents of adolescent females present a significant obstacle to achieving high vaccination rates. …”
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G-UNETR++: A Gradient-Enhanced Network for Accurate and Robust Liver Segmentation from Computed Tomography Images by Seungyoo Lee, Kyujin Han, Hangyeul Shin, Harin Park, Seunghyon Kim, Jeonghun Kim, Xiaopeng Yang, Jae Do Yang, Hee Chul Yu, Heecheon You

“…Accurate liver segmentation from computed tomography (CT) scans is essential for liver cancer diagnosis and liver surgery planning. Convolutional neural network (CNN)-based models have limited segmentation performance due to their localized receptive fields. …”
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Proceso del cuidado enfermero aplicado al adulto mayor con insuficiencia respiratoria por neumonía by Gladis Villanueva Cadenas, Edith Telma Meza Martel, Yulissa Novalí Collantes Vilchez, María del Pilar Medina Siesquén

“…Caso clínico: Adulto mayor, frágil, en dependencia total con índice de Norton 10 y Dowton 5 puntos, con antecedentes de cáncer pulmonar izquierdo, portador de drenaje toráxico, al examen físico presenta temperatura de 39,8 °C, SapO2: 88 %, FR: 27 ciclos por minuto, FC: 145 latidos por minuto, presencia de ruidos sobreagregados roncantes y crepitantes, uso de músculos accesorios y murmullo vesicular abolido en hemitórax izquierdo, tos superficial con secreciones en gran cantidad verdosas. …”
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