The role of diet and physical activity in PCOS - A Quick Review by Natalia Pawelec, Weronika Mazur, Artur Hawajski, Natalia Jankowska, Adrianna Świerzyńska, Alicja Kapciak, Julia Górny, Katarzyna Naja

“…It is associated with many possible health consequences, ranging from acne, hirsutism, and obesity to fertility problems and even the development of endometrial cancer. Treatment is tailored to the individual, depending on various complications and needs. …”
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Design and In Silico and In Vitro Evaluations of a Novel Nicotinamide Derivative as a VEGFR-2 Inhibitor by Ibrahim H. Eissa, Muhammad Abd ElGayed Bkrah, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Dalal Z. Husein

“…Besides, it exhibited cytotoxicity against HepG2 and MCF-7 cancer cell lines, with IC50 values of 35.78 ± 0.863 μM and 57.62 μM ± 0.871, comparing sorafenib’s IC50 values of 5.95 ± 0.917 μM and 8.45 ± 0.912 μM. …”
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Prognostic significance of lymph node ratio in esophageal squamous cell carcinoma: insights from the South Asian population by Sajida Qureshi, Waqas Ahmad Abbasi, Hira Abdul Jalil, Saba Mughal, Muhammad Saeed Quraishy

“…BackgroundEsophageal cancer (EC) is a significant health concern in South Asia, yet data on prognostic factors, such as lymph node ratio (LNR), in this region is limited. …”
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Immunobridging Trials: An Important Tool to Protect Vulnerable and Immunocompromised Patients Against Evolving Pathogens by Pedro Cruz, Jie Min Lam, Jehad Abdalla, Samira Bell, Jola Bytyci, Tal Brosh-Nissimov, John Gill, Ghady Haidar, Michael Hoerger, Yasmin Maor, Antonio Pagliuca, Francois Raffi, Ffion Samuels, Dorry Segev, Yuxin Ying, Lennard Y. W. Lee

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3D-Printed Anthropomorphic Phantom Framework for Spectral Photon-Counting CT: A Breast Phantom Application by Kyriaki Katsikari, Nadine Francis, Nabil Maalej, Charalampos Pitsalidis, Aamir Younis Raja

“…The breast phantom was created by segmenting an MRI image from the Duke Breast Cancer MRI dataset into two models: one for skin, fibroglandular, and carcinoma tissues, 3D-printed with e-PLA resin, and another for adipose tissue, replicated using paraffin wax. …”
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Endothelin receptor antagonists (ERAs) can potentially be used as therapeutic drugs to reduce hypertension caused by small molecule tyrosine kinase inhibitors (TKIs) by Qingjian He, Junling Lin, Chanjuan Mo, Guodong Li, Jianzhong Lu, Qiyin Sun, Lijun Cao, Haojian Gan, Quan Sun, Jiafang Yao, Shengyi Lian, WenJuan Wang

“…The emergence of targeted anti-tumor drugs has significantly prolonged the lifespan and improved the prognosis of cancer patients. Among these drugs, vascular endothelial growth factor (VEGF) inhibitors, particularly novel small molecule tyrosine kinase inhibitors (TKIs), are extensively employed as VEGF inhibitors; however, they are also associated with a higher incidence of complications, with hypertension being the most prevalent cardiovascular toxic side effect. …”
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Health Risk Assessment of Potentially Toxic Elements Contamination of Commonly Consumed Fruits in Bahir Dar Town, Northwest Ethiopia by Biset Asrade Mekonnen, Muluabay Getie Yizengaw, Haile Kassahun, Gebremariam Ketema

“…The average daily intake (ADI), hazard quotient (HQ), hazard index (HI), and target cancer risk (TCR) were estimated to assess the human health risks posed by the intake of those potentially toxic elements from the consumption of the studied fruits. …”
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Molecular and serological investigation of hepatitis B virus in patients with acute undifferentiated febrile illness at Tha Song Yang hospital, Tak Province, Thailand by Narin Thippornchai, Anon Sae-Oueng, Akanitt Jittmittraphap, Wang Nguitragool, Pornsawan Leaungwutiwong

“…Abstract Background Hepatitis B virus (HBV) infection is associated with hepatitis, often progressing to liver cirrhosis or cancer, posing a significant public health challenge, particularly in Thailand. …”
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C-MCG: Synthesis, Uptake Selectivity, and Primate PET of a Probe for Glutamate Carboxypeptidase II (NAALADase) by Martin G. Pomper, John L. Musachio, Jiazhong Zhang, Ursula Scheffel, Yun Zhou, John Hilton, Atul Maini, Robert F. Dannals, Dean F. Wong, Alan P. Kozikowski

“…Imaging of glutamate carboxypeptidase II (GCP II), also known as N -acetylated α-linked l -amino dipeptidase (NAALADase), may enable study of glutamatergic transmission, prostate cancer, and tumor neovasculature in vivo. Our goal was to develop a probe for GCP II for use with positron emission tomography (PET). …”
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Factors Requiring Adjustment in the Interpretation of Serum Carcinoembryonic Antigen: A Cross-Sectional Study of 18,131 Healthy Nonsmokers by Hae Yeon Kang, Eun Kyung Choe, Kyu Joo Park, Young Lee

“…We were able to construct the following model to predict the log-transformed CEA level: log (CEA + 0.51) = −0.204 − 0.051 (gender) + 0.005 (age) − 0.006 (BMI) + 0.008 (WBC count) + 0.016 (HB) + 0.002 (AST) + 0.062 (creatinine) + 0.054 (HbA1c). For colorectal cancer prediction, the model with the observed CEA and adjusted CEA levels had significantly high predictive power (AUC 0.756, P<0.001) than the model only including the observed CEA level (AUC 0.693, P<0.001). …”
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Photocatalytic Degradation of Trifluralin in Aqueous Solutions by UV/S2O82− and UV/ZnO Processes: A Comparison of Removal Efficiency and Cost Estimation by Fatemeh Sadeghi, Abdolmajid Fadaei, Fazel Mohammadi-Moghadam, Sara Hemati, Gashtasb Mardani

“…Trifluralin is one of the most widely used herbicides, being accounted as the cause of cancer in human. In the present research, the UV/S2O82− and ZnO/UV processes’ efficiency in the removal of trifluralin was investigated. …”
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Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults by Eric J Bow, Gerald Evans, Jeff Fuller, Michel Laverdière, Coleman Rotstein, Robert Rennie, Stephen D Shafran, Don Sheppard, Sylvie Carle, Peter Phillips, Donald C Vinh

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Risk Factors for Chronic Mastitis in Morocco and Egypt by Hanna N. Oltean, Amr S. Soliman, Omar S. Omar, Tamer F. Youssef, Mehdi Karkouri, Azza Abdel-Aziz, Ahmad Hablas, Taylor Blachley, Ali Tahri, Sofia D. Merajver

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Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review by Brijesh Singh Chauhan, Yash Pal Singh

“…It contains a variety of biologically active phyto-compounds that show a vast array of pharmacological properties, including anti-inflammatory, anti-cardiovascular, anti-oxidant, anti-cancer, anti-diabetic, anti-periodontal, anti-microbial, anti-goiter, neuroprotective, and immunomodulatory effect, etc. …”
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Repeatability, reproducibility, and the effects of radiotherapy on radiomic features of lowfield MR-LINAC images of the prostate by Parker Anderson, Nesrin Dogan, John Chetley Ford, Kyle Padgett, Garrett Simpson, Radka Stoyanova, Matthew Charles Abramowitz, Alan Dal Pra, Rodrigo Delgadillo

“…Definitive radiotherapy (RT) has been shown to be a successful method of treating prostate cancer (PCa) patients. Through radiomics, a quantitative analysis of medical images, it is possible to adapt treatment early on, which may prevent or mitigate future adverse events. …”
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Predictive role of ABC transporters in the efficacy of enfortumab vedotin for urothelial carcinoma by Toshiki Kijima, Atsuko Takada‐Owada, Hiroki Shimoda, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Hironori Betsunoh, Masahiro Yashi, Kazuyuki Ishida, Takao Kamai

“…Abstract Objective To evaluate the correlation between ATP‐binding cassette (ABC) transporter expression and therapeutic efficacy of enfortumab vedotin (EV), an antibody‐drug conjugate targeting Nectin‐4, in urothelial cancer, as only a few studies have been conducted on this topic. …”
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Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…These findings provide a basis for stabilizing intraplaque angiogenesis through VEGFR2 intervatioin, as well as cancer treatment via combination of CD137 agonists and specific VEGFR2 inhibitors.…”
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PZS‐Net: Incorporating of Frame Sequence and Multi‐Scale Priors for Prostate Zonal Segmentation in Transrectal Ultrasound by Jianguo Ju, Qian Zhang, Pengfei Xu, Tiange Liu, Cheng Li, Ziyu Guan

“…Accurate prostate zonal segmentation in TRUS videos is vital for diagnosing prostate cancer and guiding surgery. However, TRUS videos are manually recorded by urologists, resulting in no standardized coordinate system, which limits direct prostate zonal segmentation in these videos. …”
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A nomogram for predicting prognosis for young cervical neuroendocrine carcinoma: A SEER-based study and external validation by Ning Xie, Haijuan Yu, Jie Lin, Sufang Deng, Linying Liu, Yang Sun

“…Therefore, this study aims to develop an individualized prognostic nomogram for young NECC patients.Methods360 young (≤45 years old) NECC patients were retrospectively selected from the Surveillance, Epidemiology and End Results (SEER) database and were randomly located to a training cohort and an internal validation cohort in a ratio of 7:3. Data from Fujian Cancer Hospital was used as an external validation cohort. …”
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What is the NCD service capacity and disruptions due to COVID-19? Results from the WHO non-communicable disease country capacity survey in the Americas region by Anselm Hennis, Silvana Luciani, Roberta Caixeta, Carolina Chavez, Dolores Ondarsuhu

“…Government health officials from countries that are not WHO Member States were excluded.Outcome measures The availability of evidence-based NCD guidelines, essential NCD medicines and basic technologies in primary care, cardiovascular disease risk stratification, cancer screening and palliative care services were measured in 2019, 2020 and 2021. …”
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