Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination by Saad Shakir, Samantha Lane, Alison Yeomans

“…Reports with comorbidities or concurrent medication indicative of transplantation, HIV infection or cancer (‘immunocompromised’ population) were compared with each overall database population.Data extraction and synthesis Two researchers extracted data. …”
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Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies by Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Aleksandra Klimowicz, Michał Kloska, Dorota Mańkowska-Wierzbicka, Jerzy Sowiński, Marek Ruchała

“…The nonautoimmune study group (TT) consisted of 40 patients thyroidectomized due to the differentiated thyroid cancer staged pT1. The control group comprised 39 healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies. …”
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Development of a Mobile Application Platform for Self-Management of Obesity Using Artificial Intelligence Techniques by Sylvester M. Sefa-Yeboah, Kwabena Osei Annor, Valencia J. Koomson, Firibu K. Saalia, Matilda Steiner-Asiedu, Godfrey A. Mills

“…Obesity is a major global health challenge and a risk factor for the leading causes of death, including heart disease, stroke, diabetes, and several types of cancer. Attempts to manage and regulate obesity have led to the implementation of various dietary regulatory initiatives to provide information on the calorie contents of meals. …”
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Lysine Reacts with Cholesterol Hydroperoxide to Form Secosterol Aldehydes and Lysine-Secosterol Aldehyde Adducts by George Wafula Wanjala, Arnold Nola Onyango, David Rasugu Abuga, John Kamathi Muchuna, Calvin Onyango, Moses Makayoto

“…Two cholesterol secosterol aldehydes, namely, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxyaldehyde (secosterol B), are highly bioactive compounds which have been detected in human tissues and potentially contribute to the development of physiological dysfunctions such as atherosclerosis, Alzheimer’s disease, diabetes, and cancer. They were originally considered to be exclusive products of cholesterol ozonolysis and thus to be evidence for endogenous ozone formation. …”
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The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells by Xiao Liang, Chang Xu, Wanchun Wang, Xiang Li

“…The DNA methyltransferase 1 (DNMT1)/miR-34a axis promoted carcinogenesis of various types of cancers. However, no literature reported its contribution to the stemness of osteosarcoma cancer stem-like cells (OSLCs). …”
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Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice by Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo

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Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro by Yang Li, Jianfang Dong, Peiran Zhao, Ping Hu, Dawei Yang, Lei Gao, Lianzhi Li

“…All these complexes displayed moderate cytotoxicity toward esophageal cancer cell line Eca-109 with the IC50 values of 23.95 ± 2.54 μM for 1, 18.14 ± 2.39 μM for 2, and 21.89 ± 3.19 μM for 3. …”
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Monoclonal anti-CD38 therapy in human myeloma: retrospects and prospects by Alberto L. Horenstein, Angelo C. Faini, Angelo C. Faini, Fabio Morandi, Erika Ortolan, Paola Storti, Nicola Giuliani, Nicola Giuliani, Paul G. Richardson, Fabio Malavasi, Fabio Malavasi

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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

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Different immunological characteristics of asymptomatic and symptomatic COVID-19 patients without vaccination in the acute and convalescence stages by Li Li, Xin Zhang, Huimin Yan, Muwei Dai, Huixia Gao, Yuling Wang, Ping Jiang, Erhei Dai

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Co-dynamics of hepatitis B and C viruses under the influence of CTL immunity by A.M. Elaiw, GH.S. Alsaadi, A.A. Raezah, A.D. Hobiny

“…Understanding the cytotoxic T lymphocyte (CTL) immune response against hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is crucial, as these infections can lead to liver cirrhosis and cancer. Mathematical models provide valuable support for biological and medical research by helping to understand the within-host dynamics of single or multiple viral infections and by aiding the development of effective drug therapies. …”
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Universal, untargeted detection of bacteria in tissues using metabolomics workflows by Wei Chen, Min Qiu, Petra Paizs, Miriam Sadowski, Toma Ramonaite, Lieby Zborovsky, Raquel Mejias-Luque, Klaus-Peter Janßen, James Kinross, Robert D. Goldin, Monica Rebec, Manuel Liebeke, Zoltan Takats, James S. McKenzie, Nicole Strittmatter

“…We apply these TSMs to the in situ detection of bacteria using healthy and cancerous gastrointestinal tissues as well as faecal samples. …”
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Necesidad de un sistema ecográfico de estratificación del riesgo de malignidad en lesiones nodulares del tiroides by Rubén González Tabares, María del Carmen Díaz de Armas, Olayma Fernández Cedeño

“…Desarrollo: Todos los sistemas reconocen las mismas características ecográficas de riesgo: nódulos sólidos hipo ecoicos, márgenes irregulares o espiculados, forma más alta que ancha (diámetro anteroposterior mayor que el transverso) y la presencia de micro calcificaciones; aunque ninguna de ellas por sí sola es patognomónica de cáncer de tiroides. Sin embargo, utilizan nomenclaturas y número de estadios diferentes y lo más importante, la decisión de realizar o no biopsia con aguja fina difiere en dependencia de cuál se use. …”
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Theoretical Study of the Quadruple Gamma Transitions of Radioactive Radon and Radium Isotopes Based on Half-Life by Duaa Abed Salim, Waleed Jabbar Mhana, Hadeel Ghali Ishnayin, Khalid Hadi Mahdi

“… Background: This study investigated multiple aspects of radon and radium’s nuclear properties since they are heavy, radioactive elements that may emit alpha, beta, and gamma radiation, which is connected to cancer and poses a risk to the environment. The purpose of this study is to investigate the significance of quadruple gamma transitions with |M(E2)|2w.u↓ as a valuable probe of the internal structure, deformations, and energy levels of atomic nuclei. …”
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Cuproptosis Cell Death Molecular Events and Pathways to Liver Disease by Mao Y, Chen H, Zhu W, Ni S, Luo S, Tang S, Chen Z, Wang Q, Xu J, Tu Q, Chen H, Zhu L

“…Yun Mao,1,* Huilan Chen,1,* Weihan Zhu,2 Shunlan Ni,3 Shengnan Luo,3 Shiyue Tang,3 Zhiyi Chen,4 Qin Wang,3 Jinxian Xu,3 Qi Tu,5 Haijun Chen,3,* Lujian Zhu3,* 1Department of Gerontology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 3Department of Infectious Disease, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 4Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 5Department of Neurosurgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lujian Zhu; Haijun Chen, Department of Infectious Disease, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China, Email zhulj_brave@163.com; 19564367335@163.comAbstract: Chronic liver disease ranks as the 11th leading cause of death worldwide, while hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality, representing a substantial risk to public health. …”
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白介素8-251 位点基因多态性与我国高低发区胃癌关系 by 曾志荣, 周韶璋, 廖山婴, 陈斌, 李初俊, 陈旻湖, 胡品津

“…【目的】研究白介素(interleukin, IL)-8 基因- 251A/T 位点多态性在中国高、低发区普通人群和胃癌 (gastric cancer , GC)患者中的分布, 并探讨其基因多态性与我国胃癌的关系。【方法】用聚合酶链反应- 反向杂 交法(polymerase chain reaction and reverse dot blot, PCR-RDB)检测我国胃癌低发区( 广东省) 104 例健康人和 104 例胃癌患者和胃癌高发区( 陕西省) 102 例健康人和102 例胃癌患者的IL-8 基因- 251A/T 位点多态性。…”
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Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease by Hongjie Ou, Yaojie Fu, Wei Liao, Caixia Zheng, Xiaolu Wu

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Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution by Wang J, Fan H, Bao Z, Li G, Wang L, Zhang D

“…Jianwei Wang,1,* Hailang Fan,2,* Zhengqing Bao,1 Guizhong Li,1 Lingyan Wang,1 Dake Zhang2 1Urology Department, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 102200, People’s Republic of China; 2Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Engineering Medicine, Beihang University, Beijing, 100191, People’s Republic of China*these authors contributed equally to the workCorrespondence: Lingyan Wang, Urology Department, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People’s Republic of China, Email wang_lingyan@foxmail.com Dake Zhang, Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing, People’s Republic of China, Email dakezhang@buaa.edu.cnBackground: Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with a risk of cancer. Its etiology is unknown, possibly involving immune dysregulation and inflammation.Methods: Study used DNA methylation (DNAme) and single-cell RNA sequencing (scRNA-seq) to compare LS with normal skin. …”
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Circulating CD3+HLA-DR+ Extracellular Vesicles as a Marker for Th1/Tc1-Type Immune Responses by Ryutaro Oba, Motomichi Isomura, Akira Igarashi, Kinya Nagata

“…The results suggest that these EV subpopulations reflect in vivo activation status of total CD4+, total CD8+, and Th1/Tc1-type T cells, respectively, and may be helpful in T cell-related clinical settings, such as cancer immunotherapy and treatment of chronic infection, autoimmune diseases, and graft-versus-host disease.…”
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A deep learning-based integrated analytical system for tumor exosome on-chip isolation and automated image identification by Yunxing Lu, Haihui Wang, Zhou Zeng, Jianan Hui, Jiangyu Ji, Hongju Mao, Qiang Shi, Xiaoyue Yang

“…These results highlight the potential of this technique for sensitive, precise, and automatic exosome tumor detection, paving the way for early cancer diagnosis and analysis.…”
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