A scalable tool for analyzing genomic variants of humans using knowledge graphs and graph machine learning by Shivika Prasanna, Ajay Kumar, Deepthi Rao, Eduardo J. Simoes, Praveen Rao

“…By analyzing genomic variants of humans, scientists can gain better understanding of the risk factors of complex diseases such as cancer and COVID-19. To model and analyze the rich genomic data, knowledge graphs (KGs) and graph machine learning (GML) can be regarded as enabling technologies. …”
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Mortalidad hospitalaria por afecciones respiratorias en el Hospital Provincial de Cienfuegos. 2010-2014 by Liuva Leyva Rodríguez, Orlando Morera Álvarez, Daylin Madruga Jiménez, Heidy Caridad Cordero Cabrera, Reinaldo José Pino Blanco

“…Las afecciones respiratorias predominantes fueron: neumonía/ bronconeumonía, enfermedad pulmonar obstructiva crónica y cáncer de pulmón respectivamente; el 63,4 % de los casos presentaron enfermedades asociadas, fundamentalmente cardiovasculares (26, 6 %). …”
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Proximal Sessile Serrated Adenomas Are More Prevalent in Caucasians, and Gastroenterologists Are Better Than Nongastroenterologists at Their Detection by Malav P. Parikh, Sujit Muthukuru, Yash Jobanputra, Kushal Naha, Niyati M. Gupta, Vaibhav Wadhwa, Rocio Lopez, Prashanthi N. Thota, Madhusudhan R. Sanaka

“…Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. …”
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High Expression of Ten Eleven Translocation 1 Is Associated with Poor Prognosis in Hepatocellular Carcinoma by Haopeng Wen, Tengfei Ji, Liteng Lin, Nan Cheng, Kangshun Zhu, Liangqi Cao

“…However, the effect of DNA demethylation enzymes, ten eleven translocation (TET) proteins, has not been comprehensively characterized in liver cancer. In this research, we sought to unravel the linkage of TET proteins with prognosis, immune characteristics and biological pathways in hepatocellular carcinoma (HCC). …”
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Factors associated with, and variations in, COVID-19 hospital death rates in England’s first two waves: observational study by Alex Bottle, Paul Aylin, Stephen Brett, Puji Faitna

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A Retrospective Observational Cohort Analysis of Oncology Patients with Febrile Neutropenia in the Emergency Department of a Tertiary Care Hospital in Oman by Badar Al-Aamri, Aisha AL Breiki, Darpanarayan Hazra, Talib Al-Aamri, Manar Al-Shehi

“…Most patients (89.3%) presented with active cancer, and the mean neutrophil count was 0.18. High-risk patients exhibited significantly higher rates of positive blood cultures (31.6% vs. 1.6%) and positive urine cultures (20.8% vs. 7.7%). …”
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Determination of the Selected Heavy Metal Content and Its Associated Health Risks in Selected Vegetables Marketed in Bahir Dar Town, Northwest Ethiopia by Biset Asrade, Gebremariam Ketema

“…The concentrations of copper (Cu), chromium (Cr), cadmium (Cd), and lead (Pb) were determined, and their health risks were estimated using estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and target cancer risk (TCR) for selected heavy metals by using flame atomic absorption spectrometry. …”
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Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice by Masaru Yamaguchi, Khin Thandar Htun, Youta Tatara, Yoshiaki Sato, Masato Hosoda, Suchart Kothan, Chikashi Kamimura, Osamu Inanami, Ikuo Kashiwakura

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Advancing Therapeutic Strategies with Polymeric Drug Conjugates for Nucleic Acid Delivery and Treatment by Ullah A, Khan M, Zhang Y, Shafiq M, Ullah M, Abbas A, Xianxiang X, Chen G, Diao Y

“…Applications of PDCs in treating diseases such as cancer, immune disorders, and fibrosis are also discussed. …”
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Exploring the prognostic role of microbial and genetic markers in lung squamous cell carcinoma by Fan Yang, Xiaodong Jia, Zihuan Ma, Siyao Liu, Chunzi Liu, Dan Chen, Xiuju Wang, Niansong Qian, Hui Ma

“…LUSC patient data from The Cancer Genome Atlas (TCGA), including microbial genus level abundance data and RNA sequencing (RNA-Seq) data, were used as a training dataset. …”
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Direct imaging with multidimensional labelling and high‐content analysis allows quantitative categorization and characterizations of individual small extracellular vesicles and nan... by Simou Sun, Sarah J. Cox‐Vázquez, Nam‐Joon Cho, Guillermo C. Bazan, Jay T. Groves

“…This high‐content analysis reveals common cargo sorting features in sEVP subpopulations across different cell types and suggests new statistics within the sEVP inherent heterogeneity that could differentiate sEVPs from two types of cancer cells and two types of normal cells. Collectively, our study presents a robust single‐sEVP characterization platform, combining high‐content imaging with comprehensive analysis. …”
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Association of Fatty Acid Synthase with Level of Fatty Acids in Osteoporosis Patients by Abeer Hassan Alwan, Ekhlass M. Taha

“…Osteoporotic fractures are more common in women than breast cancer, myocardial infarction, or stroke, and they also incur higher hospital treatment costs. …”
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Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells by Franciele Hinterholz Knebel, Renata Chaves Albuquerque, Renato Ramos Massaro, Silvya Stuchi Maria-Engler, Ana Campa

“…These data suggest that some tumor cells are responsive to SAA and, in these cases, SAA may have a role in cancer progression that varies according to the cell type.…”
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Elucidation of the Molecular Interaction between miRNAs and the Gene, Involved in Acute Myeloid Leukemia, by the Assistance of Argonaute Protein through a Computational Approach by Rohit Pritam Das, V. Badireenath Konkimalla, Surya Narayan Rath, Jagadish Hansa, Manaswini Jagdeb

“…Acute myeloid leukemia is a well characterized blood cancer in which the unnatural growth of immature white blood cell takes place, where several genes transcription is regulated by the micro RNAs (miRNAs). …”
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Enhance health evidence quality in classification tasks: A triangulation approach utilizing case-based reasoning and process features by Ruihua Guo, Ross Smith, Qifan Chen, Angus Ritchie, Simon Poon

“…Objective Machine learning (ML) has enabled healthcare discoveries by facilitating efficient modeling, such as for cancer screening. Unlike clinical trials, real-world data used in ML are often gathered for multiple purposes, leading to bias and missing information for a specific classification task. …”
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Phytochemical profile, therapeutic potentials, nutritional composition, and food applications of ginger: a comprehensive review by Great Iruoghene Edo, Ufuoma Augustina Igbuku, Raghda S. Makia, Endurance Fegor Isoje, Tayser Sumer Gaaz, Emad Yousif, Agatha Ngukuran Jikah, Khalid Zainulabdeen, Patrick Othuke Akpoghelie, Rapheal Ajiri Opiti, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar

“…The compounds are responsible for the distinct aroma, flavor, and pharmacological activities such as anti-inflammatory, anti-oxidation, antimicrobial, anti-cancer, gastroprotective effects associated with ginger. …”
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Prediction Scores Do Not Correlate with Clinically Adjudicated Categories of Pulmonary Embolism in Critically Ill Patients by CM Katsios, M Donadini, M Meade, S Mehta, R Hall, J Granton, J Kutsiogiannis, P Dodek, D Heels-Ansdell, L McIntyre, N Vlahakis, J Muscedere, J Friedrich, R Fowler, Y Skrobik, M Albert, M Cox, J Klinger, J Nates, A Bersten, C Doig, N Zytaruk, M Crowther, DJ Cook

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TMEM101 expression and its impact on immune cell infiltration and prognosis in hepatocellular carcinoma by Lingyun Kuang, Yilin Pang, Quangang Fang

“…Abstract Hepatocellular carcinoma (HCC) is a cancer caused by inflammation, which affects the immune response and treatment outcomes. …”
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Exploration of different quantitative polymerase chain reaction-based genotyping methods to distinguish Apcmin/+ mice from wildtype mice. by Yuting Sun, Tingyu Zhou, Silin Ye, Effie Yin Tung Lau, Yao Zeng, Jessie Qiaoyi Liang

“…Apcmin/+ mice, which harbour a germline Apc mutation (g.2549T>A) associated with multiple intestinal neoplasms, are extensively employed in colorectal cancer research. In this study, we used Apc as a model and assessed the feasibility of different qPCR-based methods for SNV genotyping, considering approaches with and without genotyping analytical tools. …”
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Systematic review of functional magnetic resonance imaging (fMRI) applications in the preoperative planning and treatment assessment of brain tumors by Hamad Yahia Abu Mhanna, Ahmad Fairuz Omar, Yasmin Md Radzi, Ammar A. Oglat, Hanan Fawaz Akhdar, Haytham Al Ewaidat, Abdallah Almahmoud, Abdel-Baset Bani Yaseen, Laith Al Badarneh, Omar Alhamad, Laith Alhamad

“…A decade of fMRI development was examined in this study, with a particular emphasis on its use in diagnosing and assessing the efficacy of brain cancer treatments. We examined the foundational principles, practical implementations, and verification of fMRI via direct brain stimulation, with particular emphasis on its capacity to detect cerebral regions affected by tumors that are eloquent in nature. …”
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