Medium Time Heating of Syrop from Red Betel Leaf (Piper crocatum ruiz pav) Can Reduce Carcinoembryonic Antigen (CEA) Level Among Adult Women in Southeast Sulawesi, Indonesia by Hariani Hariani, Wiralis Wiralis, Teguh Faturrahman Teguh Faturrahman, Suwarni Suwarni

“… Background: Carcinoembryonic Antigen (CEA) is an immunoglobulin that is strongly suspected to inhibit apoptosis and is closely associated with various cancers and metastases. Red betel leaves have been shown to induce apoptosis in breast cancer cells (MCF-7), activate pro-apoptotic proteins (Bax), and inhibit anti-apoptotic proteins (Bcl-2). …”
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Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

“…Bispecific antibodies (BsAbs) are a sort of dual functional proteins with specific binding to two distinct targets, which have become a focus of interest in antibody engineering and drug development research and have a promising future for wide applications in cancer immunotherapy and autoimmune disease. The key of clinical application and commercial-scale manufacturing of BsAbs is the amenability to assembly and purification of desired heterodimers. …”
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Absolute quantification of Neuron-specific enolase based on surface plasmon resonance by Cui Lin, Yijie Wang, Tao Peng, Pengpeng Liu, Yuanyuan Liang, Wencheng Kang, Xiaoping Yu, Yang Song, Xuping Shentu

“…Neuron-specific enolase (NSE) is currently the most reliable biomarker for small cell lung cancer (SCLC), which is important for disease monitoring, clinical evaluation and diagnosis. …”
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A Histologically Complete Response to Immunotherapy Using Pembrolizumab in a Patient with Giant Cell Carcinoma of the Lung: An Additional Report and Literature Review by Tomoo Kakimoto, Mamoru Sasaki, Tatsuya Yamamoto, Arifumi Iwamaru, Kentaro Ogata, Ko Lee, Shingo Nakayama, Naoto Minematsu

“…Microscopic examination of the sample revealed no residual cancer. The patient was free from recurrence at 16 months post surgery. …”
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Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis by Joseph Malinzi, Rachid Ouifki, Amina Eladdadi, Delfim F. M. Torres, K. A. Jane White

“…Oncolytic virotherapy has been emerging as a promising novel cancer treatment which may be further combined with the existing therapeutic modalities to enhance their effects. …”
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Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss by Nina Geidenstam, Martin Magnusson, Anders P. H. Danielsson, Robert E. Gerszten, Thomas J. Wang, Lovisa E. Reinius, Hindrik Mulder, Olle Melander, Martin Ridderstråle

“…Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n=83). …”
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Protopanaxadiol manipulates gut microbiota to promote bone marrow hematopoiesis and enhance immunity in cyclophosphamide‐induced immunosuppression mice by Yuru Cao, Ben Liu, Wenzhen Li, Feng Geng, Xue Gao, Lijun Yue, Huiping Liu, Congying Liu, Zhenguo Su, Junhong Lü, Xiaohong Pan

“…Our findings reveal that PPD enhances immunity by manipulating gut microbiota and has the potential to be used as an immunomodulator in cancer chemotherapy.…”
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Medical students and ChatGPT: analyzing attitudes, practices, and academic perceptions by Ahmed Samir Abdelhafiz, Maysa I. Farghly, Eman Anwar Sultan, Moaz Elsayed Abouelmagd, Youssef Ashmawy, Eman Hany Elsebaie

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When math legitimizes knowledge: a step by step approach to Bayes’ rule in diagnostic reasoning by Yung Bruno de Mello Gonzaga, André Demambre Bacchi, Vitor Borin Pardo de Souza

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Grounded theory assessment of health needs in rural Mississippi Delta region, USA: Implications for health policy and management by Yalanda M. BARNER, Austine U. ONYIA, Russell L. BENNETT, Manoj SHARMA

“…Participants identified hypertension, diabetes, mental health, and cancer as the most prevalent diseases. Structural barriers included little access to quality foods and a lack of economic development. …”
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A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection by Bo Wang, Shanren Liu, Mengmeng Gao, Yuanjun Li, Heer Yang, Cai Sun, Qi Guo, Yongsen Yu

“…The PGTF has great potential as a simple, sensitive, and label-free assay in the field of cancer marker detection.…”
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Mature Cystic Teratoma of the Ovary; Clinicopathological Evaluation of 143 Cases in our Series, 5 Years Experience by Ferah Kazanci, Betul Ogut, Dilek Yapar, Ozlem Erdem, M. Anil Onan

“…As the final pathology report revealed, of 143 patients, immature teratoma was observed in five cases (3.5%), in one of them (0.7%) mixed germ cell tumor and in three of them (2.1%) borderline mucinous cancer, squamous cell carcinoma, and carcinoid tumor on mature cystic teratoma base were observed. …”
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Ecological and human health implications of mercury contamination in the coastal water by A. Mallongi, A.U. Rauf, R.D.P. Astuti, S. Palutturi, H. Ishak

“…From the simulation results, the concentration of mercury at 23.3% and exposure time of 21.3 percent were the most influential and dominant factors in non-cancer risk for adults and children, respectively. …”
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Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy by Jian Chen, Qiyu Zhan, Lie Li, Simin Xi, Longmei Cai, Ruiyuan Liu, Lujia Chen

“…This work represents a promising tumor therapeutic strategy combining cell membrane targeting SDT and FSP1 inhibition, potentially inspiring further research in developing logical and effective cancer therapies based on synergistic SDT/ferroptosis.…”
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Epigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA) by Wei Zhao, Lisha Lin, Kristen M. Kelly, Lauren A. Opsasnick, Belinda L. Needham, Yongmei Liu, Srijan Sen, Jennifer A. Smith

“…Identified CpGs and/or nearby genes have been implicated in cellular development pathways, transcription factor binding, cancer and multiple autoimmune and/or inflammatory diseases. …”
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Evaluating Normalization Methods for Robust Spectral Performance Assessments of Hyperspectral Imaging Cameras by Siavash Mazdeyasna, Mohammed Shahriar Arefin, Andrew Fales, Silas J. Leavesley, T. Joshua Pfefer, Quanzeng Wang

“…These findings provide a foundation for standardized performance testing of HSI-based medical devices, promoting the adoption of high-quality HSI technology for critical applications such as early cancer detection.…”
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Stevenleaf from Gynostemma Pentaphyllum inhibits human hepatoma cell (HepG2) through cell cycle arrest and apoptotic induction by Sayed Sajid Hussain, Fan Zhang, Yuanyuan Zhang, Kiran Thakur, Mahrukh Naudhani, Carlos L. Cespedes-Acuña, Zhaojun Wei

“…The anticancer activity of stevenleaf (SV) on the basis of cell viability, cell cycle, and apoptosis induction in HepG2 cancer cells were evaluated. SV controlled the growth of HepG2 cells with IC50 of 139.82 μmol/L for 24 h, IC50 of 119.12 μmol/L for 48 h and cell cycle arrested at G0/G1 phase, induced cell apoptosis and enhanced intracellular ROS generation. …”
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Utilizing physical educators to monitor muscular strength and neuromuscular control among children with varied recess time by G. Kate Webb, Yan Zhang, Deborah J. Rhea

“…Developing appropriate MusS during childhood decreases the chances of physical injuries and many chronic diseases such as type II diabetes and cancer, which leads to healthier, active future adults. …”
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Improvement of the dissolution of the antineoplastic drug regorafenib through impregnation into pullulan polysaccharide using supercritical fluid technology: Optimization of the pr... by Ali Sheikhi, Sepideh Hamedi, Gholamhossein Sodeifian, Fariba Razmimanesh

“…Regorafenib is administered orally for the treatment of metastatic colorectal cancer. However, its limited water solubility hinders its clinical efficacy. …”
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Exploring surgeon behavioural factors impacting the quality of care: protocol for a scoping review by Megan Delisle, Nicole Askin, Bhavan Dhaliwal, Doris Goubran, Orest Fylyma, Ina Siwach, Maziar Fazel Darbandi

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