Robust genome editing activity and the applications of enhanced miniature CRISPR-Cas12f1 by Soo-Ji Park, Sungjin Ju, Won Jun Jung, Tae Yeong Jeong, Da Eun Yoon, Jang Hyeon Lee, Jiyun Yang, Hojin Lee, Jungmin Choi, Hyeon Soo Kim, Kyoungmi Kim

“…Furthermore, we demonstrate that eCas12f1 efficiently induces apoptosis in cancer cells and is compatible with base editing and regulation of gene expression, verifying its high utility and applicability in gene therapy research.…”
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Fatty Acid Composition, Phospholipid Molecules, and Bioactivities of Lipids of the Mud Crab Scylla paramamosain by Thi Phuong Lan Nguyen, Van Tuyen Anh Nguyen, Thi Thanh Trung Do, Trung Nguyen Quang, Quoc Long Pham, Tat Thanh Le

“…The crab polar lipid fraction, which contained phospholipids, also presented high cytotoxic activity toward five cancer cell lines with IC50 values ranging from 85.4 to 95.8 μg/mL.…”
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Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation by Ilka Knippertz, Andrea Deinzer, Jan Dörrie, Niels Schaft, Dirk M. Nettelbeck, Alexander Steinkasserer

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Implant failure of the Compress prosthesis: a case report by Hiroshi Koike, Kunihiro Ikuta, Hiroshi Urakawa, Tomohisa Sakai, Takeo Fujito, Yoshihiro Nishida, Shiro Imagama

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Blind Spot in the Radar of MEST-C Score: Type and Severity of Tubulointerstitial Nephritis in IgA Nephropathy by Iram Asrar, Mudassar Hussain, Aurangzeb Afzal, Usman Hassan, Sheeba Ishtiaq

“…This cross-sectional descriptive study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. …”
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Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab by Francine Foss, Youn H. Kim, Julia Scarisbrick, Oleg Akilov, Robert Ristuccia, Karen Dwyer, Wende Wu, Martine Bagot

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Morphology of Welding Fume Derived from Stainless Steels Arc Welding by J. Wyciślik-Sośnierz, J. Matusiak, J. Adamiec, M. Lemanowicz, R. Kusiorowski, A. Gerle

“…Welding fume has been classified by the International Agency for Research on Cancer (IARC) as a group of agents with proven carcinogenic effects to human. …”
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Loxoscelism: Cutaneous and Hematologic Manifestations by Ngan Nguyen, Manjari Pandey

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Food insecurity increases the risk of overweight and chronic diseases in adolescents: a systematic review and meta-analysis by Chong Zhou, Hongrui Miao, Yingjun Zhao, Xiaohong Wan

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Codesign approaches involving older adults in the development of electronic healthcare tools: a systematic review by Karthik Adapa, Lukasz Mazur, Amy C Cole, Amro Khasawneh, Daniel R Richardson

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Indicators of Safety Compromise in Gastrointestinal Endoscopy by Mark R Borgaonkar, Lawrence Hookey, Roger Hollingworth, Ernst J Kuipers, Alan Forster, David Armstrong, Alan Barkun, Ronald Bridges, Rose Carter, Chris de Gara, Catherine Dube, Robert Enns, Donald MacIntosh, Sylviane Forget, Grigorios Leontiadis, Jonathan Meddings, Peter Cotton, Roland Valori, on behalf of the Canadian Association of Gastroenterology Safety and Quality Indicators in Endoscopy Consensus Group

“…The growth in the use of endoscopy to diagnose and treat many gastointestinal disorders, and its central role in cancer screening programs, has led to a significant increase in the number of procedures performed. …”
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Chemicals That Disrupt the Endocrine System and Their Effects on Behavior by Yousaf Khan1, Abdul Sattar1, Syed Amin Ullah1, Zia-Ur-Rehman2, Hakimullah3, Madeeha Bibi4, Hina Sarfraz1, Anila Mukhtiar1

“…The diseases that are commonly reported due to the action of the above chemicals and daily use items includes neurological disorders, behavioral disorders, metabolic dysfunction leading to obesity or weakness, thyroid dysfunction, reproductive disturbances and several others that can prove fatal and lead to cancer as well. All these chemicals and items are named as Endocrine Disruptors by the researchers. …”
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Primary Appendiceal Adenocarcinoma Presenting with Hematochezia due to the Invading Tumor in the Sigmoid Colon by Tatsuya Suzuki, Yasuhiro Yamamoto, Toshihiko Torigoe, Shoichiro Mizukami, Kengo Shigehara

“…A computed tomography scan showed an appendiceal mass that involved the sigmoid colon, suggesting an appendiceal cancer invading the sigmoid colon. Ileocecal resection with extended lymphadenectomy and en bloc resection of the sigmoid colon was performed. …”
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Structural basis of SIRT7 nucleosome engagement and substrate specificity by Carlos Moreno-Yruela, Babatunde E. Ekundayo, Polina N. Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz

“…SIRT7 is an NAD+-dependent deacylase often deregulated in cancer, which deacetylates either H3 lysine 36 (H3K36) or H3K18 with high specificity within nucleosomes. …”
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Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

“…Regulation of pleotropic cytokines potentially paves the way to safely use these powerful cytokines in ACT for cancer treatment.…”
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Progress of CCL20-CCR6 in the airways: a promising new therapeutic target by Ya -Jing Li, Wan-Li Geng, Chen-Chen Li, Jia-Hao Wu, Fei Gao, Yong Wang

“…Within the respiratory system, CCL20-CCR6 demonstrates heightened expression in conditions such as allergic asthma, chronic airway inflammation, non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), and other respiratory diseases, which is conducive to the inflammatory mediators recruitment and tumor microenvironment remodeling. …”
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Clinical presentation and management challenges of sphingosine-1-phosphate lyase insufficiency syndrome associated with an SGPL1 variant: a case report by Vahid Saeedi, Nahid Rahimzadeh, Fahimeh Ehsanipour, Neda Shalbaf, Amirhosein Farahi, Khalil Rashidi, Leila Kamalzadeh

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Clinical study, network pharmacology, and molecular docking of Kunxian capsule in treating idiopathic membranous nephropathy by Jia Lv, Xinyu Gao, Lihua Liu, Libing He, Geng Tian, Xuehong Lu

“…The main potential mechanism of KX in treating IMN were pathways involved in cancer, the AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis. …”
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The non-nutritive sweetener rebaudioside a enhances phage infectivity by Luigi Marongiu, Ewa Brzozowska, Jan Brykała, Markus Burkard, Herbert Schmidt, Bożena Szermer-Olearnik, Sascha Venturelli

“…However, it has become increasingly evident that their consumption is associated with bacterial dysbiosis, which, in turn, is linked to several health conditions, including a higher risk of type 2 diabetes and cancer. Among the NNS, stevia, whose main component is rebaudioside A (rebA), is gaining popularity in the organic food market segment. …”
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Potential Risks of Open Waste Burning at the Household Level: A Case Study of Semarang, Indonesia by Bimastyaji Surya Ramadan, Raden Tina Rosmalina, Syafrudin, Munawir, Hafizhul Khair, Indriyani Rachman, Toru Matsumoto

“…Although the carcinogenic risk was low, non-cancer disease risk exceeded the standard. Therefore, direct exposure of residents to OWB may pose significant health risks. …”
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