Difficult case of endoscopic ultrasonography-guided choledochogastrostomy salvaged using a stiff guidewire by Takio Narikawa, Ken Kamata, Takamitsu Komaki, Mamoru Takenaka, Masatoshi Kudo

“…Computed tomography revealed left hydronephrosis due to bladder cancer, along with common bile duct stones and marked dilation of the bile duct. …”
Get full text

Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML by Dan Liu, Silu Liu, Yujie Ji, Ziyan Jin, Zhewei He, Mengjia Hou, Dongyang Li, Xiao Ma

“…Lactylation plays a significant role in cancer, inflammation, and tissue regeneration, but the underlying mechanisms are not yet fully understood. …”
Get full text

A Case of Endometrial Carcinosarcoma Containing Sertoliform Endometrioid Carcinoma Component by Satoru Munakata, Hanae Kushibiki, Taishi Akimoto, Tsuyoshi Yamashita, Norihiko Shimoyama

“…Sertoliform endometrioid carcinomas (SECs) of the endometrium which comprise a rare subtype of endometrial cancer, typically occur in the ovary. SECs as a carcinomatous component of CS of the endometrium have not been reported. …”
Get full text

An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) by Aly M. Waseem, Ranya Mohammed Elmagzoub, Mervat Mohammed Mazhar Abdelgadir, Areej Al Bahir, N.S. Abd EL-Gawaad, Ahmed S. Abdel-Samea, Devendra Pratap Rao, Konstantinos Kossenas, Stefan Bräse, Hamada Hashem

“…These derivatives interact with critical biological targets such as enzymes, receptors, and signaling pathways, offering promising avenues for treating complex diseases like cancer and infectious diseases. Advanced studies, including molecular docking and ADMET analyses, have further clarified their pharmacological profiles, optimizing their drug-like properties and bioavailability. …”
Get full text

The heart rate on admission was associated with the mortality in elderly patients with hip fractures: a retrospective cohort study from a trauma centre in northwestern China by Zhi Yang, Wei-Song Zhang, Shao-Hua Chen, Bin-Fei Zhang

“…Age, coronary heart disease, cancer, dementia and time to operation were introduced in multivariate regression analysis. …”
Get full text

Restriction Enzyme Analysis of DNA Methylation in “Condensed” Chromatin of Ha-Ras-Transformed NIH 3T3 Cells by Maria Luiza S. Mello, Ann F. Chambers, Benedicto C. Vidal, Wolfgang Planding, Ulrich Schenck

Get full text

Image and Histologic Characterization of Intracranial Neoplasias by Martha Yudey Rodríguez Pino, Dianarelys Villafuerte Delgado, Thaimí Conde Cueto, Odalys Yanes Isray, Adelaida Martínez Godoy, Carlos Rafael Rivera Prieto

“…<strong>Background:</strong> In Cuba, as in all developed countries, cancer is the second cause of death and among it the different types of intracranial neoplasms present a morbidity of 2-3 %. …”
Get full text

A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause by Melanie Weigert, Yan Li, Lisha Zhu, Heather Eckart, Preety Bajwa, Rahul Krishnan, Sarah Ackroyd, Ricardo Lastra, Agnes Bilecz, Anindita Basu, Ernst Lengyel, Mengjie Chen

“…While a pre-menopausal secretory epithelial gene cluster is enriched in the immunoreactive molecular subtype, a subset of genes expressed in post-menopausal secretory epithelial cells show enrichment in the mesenchymal molecular type of high-grade serous ovarian cancer.…”
Get full text

Mettre l’intime en bande dessinée. Un dialogue avec Léna Merhej et Noémie Honein by Michela De Giacometti, Laura Odasso

“…In her De l’importance du poil de nez, Noémie Honein explores her experience of the disease, after discovering, at the age of twenty, that she had cancer. Translating this period of her life into comics represents to this artist a journey into the intimate relationships she maintains with her family, with a body submitted by therapies to radical transformations, and with sexuality. …”
Get full text

Hematoxylin and Eosin-stained whole slide image dataset annotated for skin tissue segmentationMendeley Data by Anum Abdul Salam, Muhammad Zeeshan Asaf, Muhammad Usman Akram, Noah Musolff, Samavia Khan, Bassem Rafiq, Babar Rao

“…These images were grouped into 12 classes including tissues, skin cancer, and skin layers. We have also validated the dataset using SegFormer, which resulted in an overall accuracy of 0.875.…”
Get full text

Inhibitory Effects of Polaprezine on the Inflammatory Response to Helicobacter pylori by Osamu Handa, Norimasa Yoshida, Yukiko Tanaka, Miho Ueda, Takeshi Ishikawa, Tomohisa Takagi, Naoyuki Matsumoto, Yuji Naito, Toshikazu Yoshikawa

“…To clarify the efficacy of polaprezinc, a chelate compound consisting of zinc and L-carnosine, against H pylori-induced inflammation including PMN infiltration, the in vitro effects of this drug on interleukin (IL)-8 production by an established gastric cancer cell line (MKN 45 cells) and on PMN-endothelial cell adhesive interactions was investigated. …”
Get full text

Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus by Fangyu Li, Rui Li, Hongjun Deng

“…Finally, we used RT-qPCR, immunofluorescence, Western blotting and Elisa to validate hub gene expression in MASLD and T2DM mouse models.ResultsThis analysis identified 20 genes shared by MASLD and T2DM that were enriched in the bile secretion, phototransduction, cancer, carbohydrate digestion and absorption, cholesterol/glycerol metabolism, and retinol metabolism. …”
Get full text

Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats by Yu Mao, Jing Zhou, Xuesheng Liu, Erwei Gu, Zhi Zhang, Wenjuan Tao

Get full text

Could Total Colectomy with Ileorectal Anastomosis Be an Alternative to Total Proctocolectomy with Ileal Pouch-Anal Anastomosis in Selected Ulcerative Colitis Patients? by Francesco Tonelli, Carmela Di Martino, Francesco Giudici

“…Failure of IRA occurred in 19 patients (15.1%); in 12 patients (9.5%), failure was related to severe proctitis, in 3 patients (2.4%), it was related to the development of high-grade dysplasia, and in 4 patients (3.2%), it was related to the development of rectal cancer. About functional results, stool consistency [liquid (6.7% of IRA patients versus 29% of IPAA patients; p=0.003)], daily soiling (0% versus 6%; p=0.01), and nocturnal soiling (6% versus 25.5%; p=0.03) were statistically different. …”
Get full text

Delayed Awareness of the History of Barium Examination: Perforated Barium Appendicitis by Susumu Saigusa, Masaki Ohi, Satoshi Oki, Takashi Ichikawa, Minako Kobayashi, Yasuhiro Inoue, Chikao Miki

“…Unfortunately, we did not obtain the history of screening for gastric cancer using a barium examination one month prior to our appendectomy. …”
Get full text

CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses by Milankumar Patel, Sudipta Panja, Lubaba A. Zaman, Pravin Yeapuri, Shaurav Bhattarai, Santhi Gorantla, Linda Chang, Alonso Heredia, Piotr Walczak, Brandon Hanson, Samuel M. Cohen, Bhavesh D. Kevadiya, Howard E. Gendelman

Get full text

The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients by Duc Anh Tran, Ba Van Nguyen, Bac Thanh Nguyen, Hoe Van Vu, Lien Duc Nguyen

Get full text

Enhancing Therapy Adherence: Impact on Clinical Outcomes, Healthcare Costs, and Patient Quality of Life by Urszula Religioni, Rocío Barrios-Rodríguez, Pilar Requena, Mariola Borowska, Janusz Ostrowski

Get full text

A chitosan/acellular matrix-based neural graft carrying mesenchymal stem cells to promote peripheral nerve repair by Zhifa Zhang, Molin Li, Gang Cheng, Peng Wang, Chunhui Zhou, Yang Liu, Xiaofeng Duan, Jing Wang, Fang Xie, Yaqiong Zhu, Jianning Zhang

Get full text

Knowledge, Attitude, and Practice towards Hepatitis B Virus among Pregnant Women Attending Antenatal Care at the University of Gondar Comprehensive Specialized Hospital, Northwest... by Teklay Gebrecherkos, Getu Girmay, Mulualem Lemma, Markos Negash

“…Majority of the respondents (85.87%) had never screened for HBV, and only 28.5% of the participants believed that hepatitis B can cause liver cancer. In multivariable analysis, residence, income, and educational level were associated with mean score knowledge and attitude. …”
Get full text