Methylation Status of Vitamin D Receptor Gene Promoter in Benign and Malignant Adrenal Tumors by Catia Pilon, Andrea Rebellato, Riccardo Urbanet, Vincenza Guzzardo, Rocco Cappellesso, Hironobu Sasano, Ambrogio Fassina, Francesco Fallo

“…We previously showed a decreased expression of vitamin D receptor (VDR) mRNA/protein in a small group of adrenocortical carcinoma (ACC) tissues, suggesting the loss of a protective role of VDR against malignant cell growth in this cancer type. Downregulation of VDR gene expression may result from epigenetics events, that is, methylation of cytosine nucleotide of CpG islands in VDR gene promoter. …”
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Follow-up computed tomography can prevent stent migration after endoscopic ultrasound-guided hepaticogastrostomy by Yasuhiro Komori, Akihisa Ohno, Nao Fujimori, Kazuhide Matsumoto, Keijiro Ueda, Kazuki Takeishi, Tomoharu Yoshizumi, Yoshihiro Ogawa

“…A 61-year-old man with obstructive jaundice caused by distal bile duct cancer recurrence was admitted to our hospital. As treatment, we performed endoscopic ultrasound-guided hepaticogastrostomy and placed a self-expanding metal stent. …”
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Repeat FNA Significantly Lowers Number of False Negative Results in Patients with Benign Nodular Thyroid Disease and Features of Chronic Thyroiditis by Dorota Słowińska-Klencka, Ewa Woźniak-Oseła, Bożena Popowicz, Stanisław Sporny, Mariusz Klencki

“…Outcome of repeat cytology implied surgery more frequently in patients with BL-CT than with BL-nCT—3.2% versus 1.9%, P < 0.05. Incidence of cancer (including incidentalomas) was higher in patients with BL-CT operated after one benign cytology than in patients with two benign FNA outcomes: 10.8% versus 1.6%, P < 0.05. …”
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Comparative Study of Regulatory T Cell Function of Human CD25+CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood by Wakae Fujimaki, Nozomu Takahashi, Kei Ohnuma, Masayoshi Nagatsu, Hiromi Kurosawa, Satoko Yoshida, Nam H. Dang, Takehiko Uchiyama, Chikao Morimoto

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PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma by Shunbin Shi, Guiping Yu, Bin Huang, Yedong Mi, Yan Kang, Julia Pia Simon

“…Previous studies showed that PPAR-gamma (PPARG) ligands might serve as potential therapeutic agents for nonsmall cell lung cancer (NSCLC). However, a few studies reported the specific relationship between PPARG and lung squamous cell carcinoma (LSCC). …”
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The role of cisplatin in modulating the tumor immune microenvironment and its combination therapy strategies: a new approach to enhance anti-tumor efficacy by Guandu Li, Xiangyu Che, Shijin Wang, Dequan Liu, Deqian Xie, Bowen Jiang, Zunwen Zheng, Xu Zheng, Guangzhen Wu

“…Exploring the interaction between cisplatin and the TIME will help identify potential therapeutic targets for improving the treatment outcomes in cancer patients.…”
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Biological age model using explainable automated CT-based cardiometabolic biomarkers for phenotypic prediction of longevity by Perry J. Pickhardt, Michael W. Kattan, Matthew H. Lee, B. Dustin Pooler, Ayis Pyrros, Daniel Liu, Ryan Zea, Ronald M. Summers, John W. Garrett

“…Age- and sex-corrected survival hazard ratio for the highest-vs-lowest risk quartile was 8.73 (95% CI,8.14-9.36) for the CT biological age model, and increased to 24.79 after excluding cancer diagnoses within 5 years of CT. Muscle density, aortic plaque burden, visceral fat density, and bone density contributed the most. …”
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FBP1 Is an Interacting Partner of Menin by Shadia Zaman, Karen Sukhodolets, Patricia Wang, Jun Qin, David Levens, Sunita K. Agarwal, Stephen J. Marx

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Inulin Reduces Kidney Damage in Type 2 Diabetic Mice by Decreasing Inflammation and Serum Metabolomics by Jiayuan He, Xiang Li, Man Yan, Xinsheng Chen, Chang Sun, Jiajun Tan, Yinsheng Song, Hong Xu, Liang Wu, Zhengnan Yang

“…The T2DM model was created by feeding the Institute of Cancer Research (ICR) mice a high-fat diet and intraperitoneally injecting them with streptozotocin (50 mg/kg for 5 consecutive days). …”
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A Real-World, Multicenter Assessment of Drugs Requiring Weight-Based Calculations in Overweight, Adult Critically Ill Patients by Sandra L. Kane-Gill, Nicholas P. Wytiaz, Lisa M. Thompson, Karina Muzykovsky, Mitchell S. Buckley, Henry Cohen, Amy L. Seybert

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Solitary metastasis in the internal auditory canal from non-small cell lung carcinoma: A case report by Julie De Boos, Marie Bruyneel, Ionela Bold

“…Discussion: IAC metastases are rare, representing only 0.3%–0.7 % of all lesions in this anatomical space. Lung cancer is a common primary source. Clinically, IAC metastases manifest with acute onset and rapid symptom progression, often mimicking benign conditions. …”
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Characterization of patients with ischemic cerebrovascular disease and cognitive impairment. Cienfuegos, 2018 by Beatriz Perdomo Borges, Teresa Rodríguez Rodríguez, Marianela Fonseca Fernández, Isabel Urquiza Pozo, Idalmis Luisa Martínez Serrano, Belkis Rosa Bilaboy Pérez

“…<p><strong>Foundation:</strong> cerebrovascular disease occupies the third place as a cause of death to be overcome only by cardiovascular diseases and cancer. It constitutes the first cause of permanent disability in the adult and the second of dementia.…”
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The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49–76 Years by Ngoc Minh Pham, Daigo Yoshida, Makiko Morita, Guang Yin, Kengo Toyomura, Keizo Ohnaka, Ryoichi Takayanagi, Suminori Kono

“…Study subjects were derived from the baseline survey of a cohort study on lifestyle-related diseases, and included 11.662 men and women aged 49–76 years; excluded were those with medication for gout and hyperuricemia, use of diuretic drugs, and medical care for cancer or chronic kidney disease. Statistical adjustment was made for body mass index, alcohol use, hypertension, diabetes mellitus, and other factors. …”
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Budget Impact of RefluxStop™ as a Treatment for Patients with Refractory Gastro-oesophageal Reflux Disease in the United Kingdom by Sam Harper, Lukasz Grodzicki, Stuart Mealing, Elizabeth Gemmill, Paul Goldsmith, Ahmed Ahmed

“…**Discussion:** While the time horizon was too short to capture some of the adverse events of PPIs and complications of GORD, such as the development of Barrett’s esophagus or esophageal cancer, the use of RefluxStop™ was associated with a substantial reduction in surgical complications, including surgical failures, reoperations, and endoscopic esophageal dilations. …”
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Partial versus complete prostatectomy specimen sampling: prospective non-inferiority study for pT3a tumours and surgical margin involvement by Mike Kliffen, Eelco R P Collette, Michael A den Bakker, Sjoerd O Klaver, André N Vis

“…All patients underwent RARP between January 2014 and February 2016 in our hospital after a diagnosis of clinically localised prostate cancer. For each patient, tumour stage and surgical margin status was recorded after partial and after complete sampling. …”
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Vitamin D Toxicity Managed with Peritoneal Dialysis by Krystel Feghali, Kostas Papamarkakis, Jackson Clark, Neha Malhotra, Lanu Stoddart, Ibitoro Osakwe

“…This is driven by a more recognized association between vitamin D sufficiency status and lower risk of cancer. In addition, more recently, it is used as a potential prophylactic and treatment for COVID-19 infection. …”
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Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Abstract To better understand drug resistance mechanisms to CDK4/6 inhibitors and inform precision medicine, we analyze real-world multi-omics data from 400 HR+/HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapies, including 200 pre-treatment and 227 post-progression samples. …”
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Assessment of Radionuclide Concentration in Surface Soil and Human Health Risk Associated with Exposure in Two Higher Institutions of Esan land, Edo State, Nigeria by F.A. Popoola, O.D. Fakeye, Q.B. Basiru, D.A. Adesina, M.A. Sulola

“…The total mean values for radiation dose estimation for Radium Equivalent Activity, Absorbed Dose, Excess Lifetime Cancer Risk, Outdoor and Indoor Annual Effective Dose Equivalent are 13.20 BqKg-1, 6.03 nGy/ℎ, 0.026, 7.40 µSτ/γ and 29.60 µSτ/γ respectively. …”
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Comparison of Tumor Non-specific and PD-L1 Specific Imaging by Near-Infrared Fluorescence/Cerenkov Luminescence Dual-Modality In-situ Imaging by Linhan Zhang MD, Lianmeng Zhao MS, Xue Lin MD, Sheng Zhao MD, Wenbin Pan MS, Dandan Wang MD, Zhongqi Sun MD, Jinping Li MD, Zonghui Liang MD, Rongjun Zhang MS, Huijie Jiang MD

“…Background Labeled antibodies are excellent imaging agents in oncology to non-invasively visualize cancer-related antigens expression levels. However, tumor tracer uptake (TTU) of specific antibodies in-vivo may be inferior to non-specific IgG in some cases. …”
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Evaluating the occurrence of trihalomethanes in drinking water and their implications for human health risk by Victor Constantin Cojocaru, Valentina Andreea Petre, Ana Ioana Paris, Nicolae Ionut Cristea, Florentina Laura Chiriac, Ioana-Antonia Cimpean

“…Carcinogenic risk assessments indicate a similar trend, with total risks for women varying between 1.37×10-6 and 1.88×10-4, and for men between 2.22×10-7 and 1.66×10-4. comparable values for cancer risk that exceed the minimum or negligible risk threshold established by the USEPA (1.00×10-6).…”
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