Clinicopathological Findings of Retinoblastoma: A 10-Year Experience from a Tertiary Hospital in Kampala, Uganda by James Joseph Yahaya, Belson Rugwizangoga, Alex Mremi, Asafu Munema

“…Retinoblastoma (RB) is one of the most common cancers occurring in young children in sub-Saharan Africa. …”
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Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Abstract Vincristine (VCR) is one of the most widely used chemotherapy agents in treating pediatric cancer. Nonetheless, it is known to cause dose-dependent neurotoxicity which can impact virtually every organ system. …”
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Trends in incidence, prevalence, and mortality of non-communicable diseases in Iraq (2003–2021) by Mohammed Merzah

“…However, older males still face high death rates from cardiovascular diseases. Rising cases of cancer, diabetes, and kidney diseases signal the need for targeted interventions. …”
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Assessing the Therapeutic Potential of Arctium lappa L. (Burdock Root) Ethanol Extract in Wound Healing on Male Rattus norvegicus by Imam Faizal, Jodi Irmansa, Ira Pangesti, Frinsisca Oktaviany, Aprillia Avivah Ledyana Mas’ud, Dilla Putri Oktafiani, Silviana Dwi Yuniasari

“…Burdock root (Arctium lappa L.) is a good plant for wound healing because it contains lignans, flavonoids, and phenolic acid which have the potential as anti-inflammatory, anti-allergic, anti-cancer, free radical scavengers and antioxidants. …”
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Relaxin inhibits 177Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway by Xu Junhua, Wan Song, Chen Wei, Zhang Yi, Ji Zhenzhong

“…177Lu-EDTMP (Ethylenediamine tetramethylene phosphonic acid) is the most used radioactive agent for pain palliation in bone cancer patients. The present study aims to study the impact of relaxin-2 on the 177Lu-EDTMP associated cell toxicity and death in osteosarcoma cells. …”
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Neutrophil-to-lymphocyte ratio as a predictor for early mortality in older patients requiring hemodialysis; insights for hemodialysis access planning by Hyo Kee Kim, Heungman Jun, Sun-Young Ko

“…Multivariate analysis for one-year mortality revealed that the preoperative neutrophil-to-lymphocyte ratio demonstrated a 1.15 hazard ratio ( p < 0.001 ). Also, cancer (HR 2.50, p = 0.02) and peripheral arterial disease (HR 4.62, p < 0.001) were risk factor for one-year mortality. …”
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Depressive symptomatology in Brazil: perspectives of statistical and psychometrics analyses of the PHQ-9 at four time-points (2020–2023) in the COVID-19 pandemic by Andre Faro, Daiane Nunes, Derek Falk

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Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action by Humberto Nicastro, Claudia Ribeiro da Luz, Daniela Fojo Seixas Chaves, Luiz Roberto Grassmann Bechara, Vanessa Azevedo Voltarelli, Marcelo Macedo Rogero, Antonio Herbert Lancha

“…The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. …”
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Representing unsegmented vessels using available vascular data for bioheat transfer simulation by Rohan Amare, Amir A. Bahadori, Amir A. Bahadori, Steven Eckels, Steven Eckels

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Associations between an gene polymorphism and ulcerative colitis by ARMS-PCR by Mahsa Sadat Hashemi Doulabi, Reza Goleyjani Moghaddam, Ali Salehzadeh

“…This finding is of note because the occurrence of intestinal inflammation and subsequent ulcers can precede the development of cancer.…”
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Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma by Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi

“…Renal cell carcinoma (RCC) accounts for the majority of cancer-related deaths worldwide. Overexpression of CD70 has been linked to advanced stages of RCC. …”
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Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion by Yang Xia, Chunye Huang, Min Zhong, Hongguang Zhong, Ruiwen Ruan, Jianping Xiong, Yangyang Yao, Jing Zhou, Jun Deng

“…In this review, we examine the impact of abnormal activation of the HGF/c-MET signaling pathway on the control of the TME and the processes governing PD-L1 expression in cancer cells. The review thoroughly examines both clinical and practical evidence regarding the use of c-MET inhibitors alongside PD-1/PD-L1 inhibitors, emphasizing that focusing on c-MET with immunotherapy enhances the effectiveness of treating MET tumors exhibiting elevated PD-L1 expression.…”
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Removing limitations surrounding terpenoid biosynthesis by biotechnological techniques in Ferula sp.: A review by Zahra Aghaali, Jun-Li Yang, Mohammad Reza Naghavi, Meisam Zargar

“…Since ancient times, Ferula species has been utilized to treat various health issues, such as asthma, toothache, inflammation, cancer, and digestive disorders. Besides, a growing body of research proves the healing efficacy of Ferula plants in treating modern diseases, such as multiple sclerosis (MS), HIV, and COVID19. …”
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Carcinoma hepatocelular gigante en hígado cirrótico. Presentación de un caso y revisión de la literatura by Jorge Luis Montes de Oca Mastrapa, Johnny Pérez Betancourt, Alejandro Cisneros Carmenate

“…Constituye el sexto tumor más habitual en el mundo, entre 500.000 y un millón de casos diagnosticados cada año y es la segunda causa más común de muerte por cáncer. La enfermedad se desarrolla de manera casi exclusiva en pacientes con una enfermedad hepática crónica subyacente, del 85 al 95 %, que han desarrollado cirrosis. …”
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Efficacy and Safety of Endoscopic Submucosal Dissection for Dysplasia in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis by Qi-Shan Zeng, Zhi-Jing Zhao, Jiao Nie, Min Zou, Jia-Hui Yang, Jin-Zhi Zhang, Hua-Tian Gan

“…Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer. Current guidelines recommend endoscopic resection if the lesion is visible with distinct margins and a complete resection can be achieved. …”
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HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China by Fangli Cao, Hui Han, Fang Zhang, Baozhong Wang, Wei Ma, Yanwen Wang, Guiming Sun, Miao Shi, Yubo Ren, Yufeng Cheng

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Molecular and Clinical Overview of Type 1 Neurofibromatosis: Single Center Study and Mini Review on NF1-Associated Vasculopathy and Juvenile Myelomonocytic Leukemia by Şule Altıner, Alper Han Çebi

“…Although JMML is a rare childhood cancer, it is accompanied by RASopathies. It is important to investigate this association because JMLL treatment approaches change in the presence of germline mutations.…”
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Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology by Jessica Ramirez, Pincas Bitterman, Sanjib Basu, Animesh Barua

“…In addition, we examined changes in nuclear expression of IL-16 expression with regards to exposure to follicle-stimulating hormone (FSH) by in vitro cell culture assays with human ovarian cancer cells. The frequencies of IL-16 expressing cells were significantly higher in ovarian stroma in women at early and late menopause as compared with premenopausal women (P<0.0001). …”
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DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target by Markos Despotidis, Orestis Lyros, Tatiana S. Driva, Panagiotis Sarantis, Emmanouil I. Kapetanakis, Adam Mylonakis, Andreas Mamilos, Stratigoula Sakellariou, Dimitrios Schizas

“…However, it has been shown that in several GI cancers, including esophageal cancer, DKK1 may act as an oncogene itself through Wnt-independent signaling pathways. …”
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Uncovering the significance of CBX3 as an up-and-coming biomarker in cardio-vascular health by Muhammad Aamir Wahab, Nunzio Del Gaudio, Biagio Gargiulo, Vincenzo Quagliariello, Nicola Maurea, Michele Grieco, Rosaria Benedetti, Angela Nebbioso, Lucia Altucci, Mariarosaria Conte

“…In patients with CVD affected by lung cancer risk, CBX3 exerts a sophisticated mechanism of action, suppressing the proliferation, migration, and formation of neointima in vascular smooth muscle cells (VSMCs) by affecting the Notch3 pathway, indicating a potential protective function against vascular remodeling and atherosclerosis. …”
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