Age-period-cohort analysis of self-harm incidence rates by gender in Iran among individuals aged 10–39 years, 1990–2019 by Yousef Ramazani, Alireza Abdi, Shahab Rezaeian, Farid Najafi, Zhyla Aliyavari, Mehdi Moradinazar

“…Data was stratified into six age groups and six five-year periods, and analyzed using the APC Web Tool from the National Cancer Institute. The average incidence rates of self-harm attempts and deaths among individuals aged 10–39 years were 93.87 and 7.55 per 100,000 individuals, respectively. …”
Get full text

Implications for the diagnosis of aspiration and aspergillosis in critically ill patients with detection of galactomannan in broncho-alveolar lavage fluids by Simon Dubler, Michael Etringer, Christoph Lichtenstern, Thorsten Brenner, Stefan Zimmermann, Paul Schnitzler, Bettina Budeus, Fabian Rengier, Paulina Kalinowska, Yuan Lih Hoo, Markus A. Weigand

Get full text

Isolation and Bioactivity of Natural Products from <i>Streptomyces</i> sp. MA37 by Fleurdeliz Maglangit, Qing Fang, Jioji N. Tabudravu, Kwaku Kyeremeh, Marcel Jaspars, Hai Deng

“…We also demonstrate that legonoxamine A possesses potent anticancer activity (IC₅₀ = 2.2 µM), exhibiting a remarkable ~30-fold increase in potency against MCF-7 ATCC HTB-22 breast cancer cells compared to desferrioxamine B, a structural analogue of legonoxamine A (IC₅₀ = 61.1 µM). …”
Get full text

Zika virus has an oncolytic activity against human glioblastoma U87 cells by V. A. Svyatchenko, I. A. Razumov, E. V. Protopopova, A. V. Demina, O. I. Solovieva, E. L. Zavjalov, V. B. Loktev

“…Glioblastoma is a highly lethal brain cancer. Virotherapy with the use of oncolytic viruses has since recently been regarded as a promising approach for the clinic treatment of human glioblastomas. …”
Get full text

Posterior Reversible Encephalopathy Syndrome Associated with FOLFOX Chemotherapy by Luiz Carlos Porcello Marrone, Bianca Fontana Marrone, Tharick Ali Pascoal, Lucas Porcello Schilling, Ricardo Bernardi Soder, Sheila Schuch Ferreira, Giovani Gadonski, Jaderson Costa da Costa

“…We report a case of a 27-year-old woman that developed PRES after the use of FOLFOX 5 (oxaliplatin/5-Fluoracil/Leucovorin) chemotherapy for a colorectal cancer.…”
Get full text

Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand by Taweesak Tongtawee, Soraya Kaewpitoon, Natthawut Kaewpitoon, Chavaboon Dechsukhum, Wilairat Leeanansaksiri, Ryan A. Loyd, Likit Matrakool, Sukij Panpimanmas

“…The Mdm2 SNIP309 G/G homozygous genotype might be a risk factor for gastric cancer and the fact that it is infrequent in Thailand.…”
Get full text

Effective and Engaging Active Learning in the Medical School Classroom: Lessons from Case-Based Collaborative Learning by Henrike C. Besche, Randall W. King, Keri M. Shafer, Sarah E. Fleet, Julia F. Charles, Tamara B. Kaplan, Katie A. Greenzang, Melanie P. Hoenig, Richard M. Schwartzstein, Barbara A. Cockrill, Krisztina Fischer

Get full text

Modulation of Apoptosis and ER Stress Markers in Hepatocellular Carcinoma Cells by Irinotecan, Hesperidin, and Piperine by Serkan Sen, Kardelen Kocaman Kalkan, Canan Yilmaz, Sefa Celik

“…Aim: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, and there is a pressing need to explore novel therapeutic strategies that enhance the efficacy of existing treatments. …”
Get full text

Suicide following the death of a sibling: a nationwide follow-up study from Sweden by Ichiro Kawachi, Jan Saarela, Mikael Rostila

“…Associations with other main causes of death—such as external other than suicide, cardiovascular diseases or cancer—were generally much smaller and statistically not significant in either sex. …”
Get full text

Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment by Francesca Sardina, Federica Polverino, Sonia Valentini, Claudia Carsetti, Elisabetta Falvo, Giada Tisci, Silvia Soddu, Fabiola Moretti, Alessandro Paiardini, Cinzia Rinaldo

Get full text

La implementación de la política pública de salud sexual y reproductiva (SSR) en el Eje Cafetero colombiano: el caso del embarazo adolescente by Sara E. del Castillo Matamoros, André Noël Roth Deubel, Clara Inés Wartski Patiño, Ricardo Rojas Higuera, Orlando Arnulfo Chacón Barliza

“…La política nacional de salud sexual y reproductiva (SSR) definida en Colombia en 2002 por el Ministerio de la Protección Social para los años 2002 a 2006 señala los temas prioritarios en este campo: maternidad segura, planificación familiar, salud sexual y reproductiva de las y los adolescentes, cáncer de cuello uterino, infecciones de transmisión sexual y reproductiva, VIH/SIDA, y violencia doméstica y sexual. …”
Get full text

Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis by Xidong He, Yuanxue Gao, Qi Liu, Zhifang Zhao, Wanhang Deng, Hong Yang

“…The receiver operating characteristic curves for the combination of the QuantiFERON-TB test and the use of erythrocyte sedimentation rate, serum adenosine deaminase level, serum cancer antigen 125 level, and hypersensitive C-reactive protein level had an area under the curve of 0.859 (95% confidence interval: 0.809–0.909), with a sensitivity and specificity of 97.26% and 62.96%, respectively. …”
Get full text

Factors Associated with the Incidence and Severity of New-Onset Atrial Fibrillation in Adult Critically Ill Patients by Péricles A. D. Duarte, Gustavo Elias Leichtweis, Luiza Andriolo, Yasmim A. Delevatti, Amaury C. Jorge, Andreia C. Fumagalli, Luiz Claudio Santos, Cecilia K. Miura, Sergio K. Saito

Get full text

The outcomes of recent patient safety education interventions for trainee physicians and medical students: a systematic review by Charles Vincent, Nick Sevdalis, Sonal Arora, Paul Baker, Matthew A Kirkman, Maria Ahmed

Get full text

Exercise promotes peripheral glycolysis in skeletal muscle through miR-204 induction via the HIF-1α pathway by Sang R. Lee, Kang Joo Jeong, Moeka Mukae, Jinhee Lee, Eui-Ju Hong

“…Some microRNAs (miRs) are secreted from skeletal muscle after exercise where they regulate insulin sensitivity, and have potential as diagnostic markers in diabetic patients. miR-204 is well-known for its involvement in development, cancer, and metabolism; however, its role in exercise-induced glycemic control remains unclear. …”
Get full text

Structural characterization of two γδ TCR/CD3 complexes by Mohammed Hoque, John Benji Grigg, Trudy Ramlall, Jennifer Jones, Luke L. McGoldrick, John C. Lin, William C. Olson, Eric Smith, Matthew C. Franklin, Tong Zhang, Kei Saotome

“…Abstract The T-cell receptor (TCR)/CD3 complex plays an essential role in the immune response and is a key player in cancer immunotherapies. There are two classes of TCR/CD3 complexes, defined by their TCR chain usage (αβ or γδ). …”
Get full text

Heterogeneity of Clostridioides difficile asymptomatic colonization prevalence: a systematic review and meta-analysis by Daniel De-la-Rosa-Martínez, Rodrigo Villaseñor-Echavarri, Diana Vilar-Compte, Virna Mosqueda-Larrauri, Paola Zinser-Peniche, Seth Blumberg

“…Among pooled estimates, a high prevalence was observed in patients with cystic fibrosis, outbreak settings, and cancer patients, whereas the lowest rates were found in healthy individuals and healthcare workers. …”
Get full text

Identification of KIFC1 as an independent prognostic marker in renal clear cell carcinoma correlates with tumor proliferation and immune infiltration by Bin Du, Jia Wang, Jinping Zheng, Jing Huo, Pu Wang

“…Abstract Renal clear cell carcinoma (ccRCC) is the world's most common form of cancer. Up to a third will develop metastases; the 5-year survival rate of the patients was only 14%. …”
Get full text

The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without Löfgren’s Syndrome by Eva Novosadova, Alzbeta Chabronova, Vitezslav Kolek, Martin Petrek, Zdenka Navratilova

“…Bioinformatics predicted consistently “Pathways in cancer” to be modulated by both altered profiles in patients with/without LS. …”
Get full text

Development of an interpretable machine learning model based on CT radiomics for the prediction of post acute pancreatitis diabetes mellitus by Xiyao Wan, Yuan Wang, Ziyi Liu, Ziyan Liu, Shuting Zhong, Xiaohua Huang

Get full text