Social innovations to increase health coverage: evidence from a crowdsourcing contest in Ghana by Joseph D Tucker, Phyllis Dako-Gyeke, Phyllis Awor, Emmanuel Asampong, Kwabena Opoku-Mensah, Philip Teg-Nefaah Tabong

“…These submissions can be put into three main themes: technology and strengthening (eg, mHealth for cervical cancer screening, video directly observed therapy), inclusiveness and reaching the marginalised (people with disability and infertility) and data utilisation for project improvement (seasonal calendar to reduce morbidity and mortality of children under 5 for malaria, diarrhoea and pneumonia).Conclusion In conclusion, this study shows that solutions to local problems exist. …”
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Implicit bias assessment by career stage in medical education training: a narrative review by Alisha Crump, May Saad Al-Jorani, Sunya Ahmed, Ekas Abrol, Shikha Jain

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Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4 by Zheng-Cai Jia, Bing Ni, Ze-Min Huang, Yi Tian, Jun Tang, Jing-Xue Wang, Xiao-Lan Fu, Yu-Zhang Wu

“…MAGE-A antigens belong to cancer/testis (CT) antigens that are expressed in tumors but not in normal tissues except testis and placenta. …”
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Metabolomic and microbiota profiles in cervicovaginal lavage fluid of women with high-risk human papillomavirus infection by Su Shen, Shixian Zhao, Jinjun Shan, Qingling Ren

“…Abstract The presence of high-risk human papillomavirus (HR-HPV) contributes to the development of cervical lesions and cervical cancer. Recent studies suggest that an imbalance in the cervicovaginal microbiota might be a factor in the persistence of HR-HPV infections. …”
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The presence of elafin, SLPI, IL1-RA and STNFα RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation by U. Westin, M. Nyström, I. Ljungcrantz, B. Eriksson, K. Ohlsson

“…We have now found the presence of elafin and SLPI in squamous cell carcinomas of the upper respiratory tract (tonsillar, hypopharyngeal, tongue, mouth floor, gingival and laryngeal cancer). Significantly higher amounts of SLPI and elafin are present in well-differentiated and moderately differentiated tumours than in poorly differentiated tumours (p<0.0001 and p<0.0015). …”
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Investigating the antimicrobial activity of silver nanoparticles with varying charges green-synthesized from Tabebuia rosea flower by Trung Dien Nguyen, Thao Phuc-Nguyen Nguyen, Nhung Thi-Tuyet Thai, Yen Hai Hoang, Gia Thi-Ngoc Trinh

“…The antimicrobial and anticancer activities of these biosynthesized nanoparticles were evaluated against gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, and Salmonella enterica), gram-positive bacteria (Bacillus subtilis, Lactobacillus fermentum, and Staphylococcus aureus), and cancer cell lines (A549, Hep-G2, KB, and MCF-7). These results highlight the crucial role of surface stabilizers, particle size, and charge in determining the biomedical potential of nanosilver particles. …”
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HSP90 inhibitors promote cell death by degrading Met and BCR::ABL1 in both imatinib-resistant and -sensitive chronic myeloid leukemia cells by Masanobu Tsubaki, Taira Matsuo, Rie Komori, Noriaki Nagai, Tetsushi Yamamoto, Shozo Nishida

“…Heat shock protein 90 (HSP90) functions as a molecular chaperone and is known for its overexpression in various types of cancer, thereby HSP90 is a potential candidate for the treatment of BCR::ABL1 TKI-resistant and -sensitive CML. …”
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Design, Synthesis and Pharmacological Screening of β-Amino-, Thiadiazole/Thiadiazine-Phosphonate Based Triazole Motifs as Antimicrobial/Cytotoxic Agents by Abdou Wafaa M., Ganoub Neven A., Sabry Eman

“…The results showed that all synthesized compounds reflected remarkable antitumor activity against breast (especially MDA-MB-231/ATCC and BT-549), and prostate carcinoma cell lines (PC-3 and DU-145), whereas a moderate to good effect on ovarian and liver cancer cells was observed.…”
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A Diagnostic Study Using STARD Platform on Liquid-Based Cytology in Cervical Smear and Its Positivity Rate among Females with Abnormal Vaginal Conditions Attending a Tertiary Care... by Mohd Afzal, Abhishek Sharma, Vikas Tiwari, Jaishree Karnwal Tiwari

“…Aim: This study aims to investigate cervical smears prepared using the Ezi-Prep LBC method and analyze the positivity rate for cervical cancer and assess the diagnostic accuracy of LBC in detecting cervical abnormalities among females with abnormal vaginal conditions attending a tertiary care center. …”
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Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System by Bella S. Guerrouahen, Heba Sidahmed, Asma Al Sulaiti, Moza Al Khulaifi, Chiara Cugno

“…Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development.…”
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Colonic growth factors (G-CSF, GM-CSF) and chemokines (MCP-1, MIP-1β) in severe ulcerative colitis by Yevgeny A. Konovich, K. Ye. Shirokikh, M. V. Shapina, Igor L. Khalif

“…Biopsy specimens of uninvolved colonic mucosa resected in 10 cancer patients were used as a control. Results. Growth factor and chemokine levels were significantly elevated in colonic biopsy specimens of UC patients in comparison to that of controls: G-CSF 52,5±17,0 and 0,4±0,1 pg/10 mg (p MIP-1β - in 17 (89,4%) and 12 (63,1%) of 19 colonic biopsies of UC patients with severe inflammatory activity. …”
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PHOTODYNAMIC THERAPY OF CONDYLOMATA ACUMINATE by V. N. Galkin, A. V. Molochkov, V. A. Molochkov, S. V. Korenev, T. E. Sukhova, Zh. S. Kuntcevich, Yu. S. Romanko

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Automated karyogram analysis for early detection of genetic and neurodegenerative disorders: a hybrid machine learning approach by Sumaira Tabassum, M. Jawad Khan, Javaid Iqbal, Asim Waris, M. Adeel Ijaz

“…Anomalous chromosomes are the cause of genetic diseases such as cancer, Alzheimer's, Parkinson's, epilepsy, and autism. …”
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Development of a New Questionnaire to Assess the Social Impact of Non-communicable Diseases by Ishani Hanspal, Farah Naaz Fathima, Karthik Murali, Abhay Sood, Fathima Ayoob, Tinku Thomas

“…Material and Methods: A cross-sectional study was conducted among patients and caregivers seeking care at a tertiary care hospital for diabetes, hypertension, chronic obstructive pulmonary disease (COPD), stroke, coronary artery disease (CAD), and cancer. Thirty patients each with the above diseases were administered Cousineau Self-Perceived Burden Scale to assess perceived burden among patients, Caregiver Burden Scale to assess caregiver burden, EuroQol-5D-3L to assess the quality of life, and face validated questions of sociodemographic details, cost of healthcare, and stress due to disease. …”
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Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome) by Majid Alfadhel, Bashayr S. Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S. Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

“…Abstract Sperm-associated antigen 9 (SPAG9) is a member of cancer-testis antigen, having characteristics of a scaffold protein, which is involved in the c-Jun N-terminal kinase JNK signaling pathway, suggesting its key involvement in different physiological processes, such as survival, apoptosis, tumorigenesis, and cell proliferation. …”
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Immunomodulatory Properties of HLA-G in Infectious Diseases by Laurence Amiot, Nicolas Vu, Michel Samson

“…The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. …”
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Preserving the Mucosa to the Maximum Possible Extent for Endoscopic Submucosal Dissection of Subcircumferential Superficial Esophageal Carcinoma by Masaya Uesato, Kentarou Murakami, Yoshihiro Nabeya, Kazunori Fugo, Hisahiro Matsubara

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Enhancing Thyroid Nodule Detection in Ultrasound Images: A Novel YOLOv8 Architecture with a C2fA Module and Optimized Loss Functions by Shidan Wang, Zi-An Zhao, Yuze Chen, Ye-Jiao Mao, James Chung-Wai Cheung

“…Thyroid-related diseases, particularly thyroid cancer, are rising globally, emphasizing the critical need for the early detection and accurate screening of thyroid nodules. …”
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Papillary Thyroid Carcinoma Semantic Segmentation Using Multi-Scale Adaptive Convolutional Network With Dual Decoders by Thanat Payatsuporn, Pittipol Kantavat, Nichthida Tangnuntachai, Nopporn Tipparawong, Waratchanok Techapapa, Boonserm Kijsirikul, Somboon Keelawat

“…Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Currently, pathologists diagnose the PTC by interpreting their nuclei. …”
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Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit by Christophe Laumonnerie, Maleelo Shamambo, Daniel R. Stabley, Tommy L. Lewis, Niraj Trivedi, Danielle Howell, David J. Solecki

“…In this circuit, the Partitioning defective 3 (Pard3) polarity protein and Junctional adhesion molecule-C (JamC) adhesion molecule promote, while the Seven in absentia 2 (Siah2) ubiquitin ligase inhibits, Deleted in colorectal cancer (Dcc) receptor surface recruitment to gate differentiation linked repulsion to GZ Netrin-1. …”
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