Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review by Virginie Lienart, Birgit Carly, Xin Kang, Laura Guzy, Anna-Maria Sajovitz, Fabienne Liebens

“…Breast density (BD) is recognized as one of the strongest independent risk factors of breast cancer (BC). Unlike most other risk factors, BD can be modified, suggesting that it may be a biomarker for preventive interventions. …”
Get full text

Cardamom extract alleviates tamoxifen-induced liver damage by suppressing inflammation and pyroptosis pathway by Wedad S. Sarawi, Hala A. Attia, Afraa Alzoubi, Nour Alanazi, Raeesa Mohammad, Rehab A. Ali

“…Abstract Tamoxifen (TAM) is extensively used to manage estrogen receptor-positive breast cancer. Despite its effectiveness, its administration can negatively impact various organs, including the liver. …”
Get full text

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach by Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia

“…The pathways of Eicosanoid Synthesis, TGF-beta signaling pathway, Prostaglandin Synthesis and Regulation, and Integrated Pancreatic Cancer Pathway were found to be significantly dysregulated in the progression of T2D. …”
Get full text

RNA binding protein ALYREF regulates ferroptosis to facilitate LUAD growth and metastasis via promoting SLC7A11 mRNA stability by Yanni Chen, Ting Zhao, Hao Chen, Jun Chen, Weili Han

“…Meanwhile, its function and regulatory role in lung cancer remains ambiguous. In this study, we discovered by WB and IHC that ALYREF has a higher expression in lung adenocarcinoma (LUAD) tissues compared with normal ones. …”
Get full text

Reconstrucción mamaria postmastectomía subcutánea con patrón de marcaje Wise. Presentación de un caso by Raquel Rojas Bruzón, Yulexis Hechavarría Jiménez, Annarelis Pérez Pupo, Aracely Lores Cruz

“…La mastectomía reductora de riesgo, también conocida como mastectomía profiláctica, consiste en extirpar la mayor cantidad de tejido posible de una mama sana para reducir el riesgo potencial de desarrollar cáncer. Se presenta el caso de una paciente de 30 años de edad, de color de piel negra, multípara y con antecedentes de padecer desde muy joven enfermedad macroquística de mamas. …”
Get full text

Association between a Primitive Brain Tumor and Cerebral Aspergillosis by Siegfried Hélage, Charles Duyckaerts, Danielle Seilhean, Jean-Jacques Hauw, Jacques Chiras

“…It can arise in immunocompetent patients treated with prolonged corticotherapy or chemoradiotherapy for cancer. A case of lethal cerebral aspergillosis in a patient with an infiltrative glioma treated with corticotherapy and radiotherapy is reported. …”
Get full text

Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 by Hilmi Farhan Ramadhani, Annisa Annisa, Aryo Tedjo, Dimas R. Noor, Wisnu Ananta Kusuma

Get full text

AMEND 2.0: module identification and multi-omic data integration with multiplex-heterogeneous graphs by Samuel S. Boyd, Chad Slawson, Jeffrey A. Thompson

“…AMEND was applied to two real-world multi-omic datasets: renal cell carcinoma data from The cancer genome atlas and an O-GlcNAc Transferase knockout study. …”
Get full text

Inonotus hispidus (Bull.) P. Karst. - bioecological characteristics, significance and possibility of use for medical purposes (medicinal properties) by Radulović Zlatan, Karadžić Dragan, Milenković Ivan

“…The fungus I. hispidus has a large number of compounds that have potential applications in the treatment of various diseases in humans, commonly in the treatment of various types of cancer.…”
Get full text

Factores que influyen en la demora diagnóstica de la neoplasia de pulmón en egresados vivos by Birsy Suárez Rivero, Damaris Reyes Hernández, Alujy Suárez Rivero, Alain Rosell Suárez

“…   Introducción: el cáncer de pulmón es el tumor maligno más frecuente en el mundo, en Cuba es la segunda causa de muerte, su pronóstico depende de diferentes factores entre ellos el intervalo entre el primer síntoma y el inicio del tratamiento. …”
Get full text

Pathological margins and advanced cutaneous squamous cell carcinoma of the head and neck by T. J. Phillips, B. N. Harris, M. G. Moore, D. G. Farwell, A. F. Bewley

“…Abstract Objective The recommended treatment for cutaneous squamous cell cancer (CuSCC) of the head and neck is Mohs surgical excision or wide local excision. …”
Get full text

Pepsinogen Serology and Gastritis OLGA Staging in Mucosal Atrophy Assessment: A Cross-Sectional Study Involving East China Endoscopy Population by Junjun Xia, Zhenzhen Liu, Kaiguang Zhang

“…The histological gastric stage (OLGA) plays an important role in evaluating gastric atrophy, a symptom which suggests a risk of gastric cancer (GC). However, gastroscopy is an invasive examination, which has limited application in populations undergoing physical examination. …”
Get full text

Tumor Markers in Pleural Fluid: A Comprehensive Study on Diagnostic Accuracy by Vladimir Aleksiev, Daniel Markov, Kristian Bechev

“…These effusions are a leading cause of debilitating dyspnea and a diminished quality of life among cancer patients, with distant metastasis to the pleural layers occurring in about 20% of cases during treatment. …”
Get full text

Characterization of Malignant Melanoma Using Vibrational Spectroscopy by Ziad Hammody, Ranjit Kumar Sahu, Shaul Mordechai, Emanuela Cagnano, Shmuel Argov

“…Malignant melanoma, a malignant neoplasm of epidermal melanocytes is the third most common skin cancer. In many cases, melanoma develops from nevus, which is considered as the nonmalignant stage. …”
Get full text

DVGEDR: a drug repositioning method based on dual-view fusion and graph enhancement mechanism in heterogeneous networks by Dongjiang Niu, Lianwei Zhang, Beiyi Zhang, Qiang Zhang, Shanyang Ding, Hai Wei, Zhen Li

“…In case study, DVGEDR identifies 10 new candidate drugs for breast cancer and COVID-19, demonstrating not only superior performance in experimental settings but also potential therapeutic advantages in clinical environments. …”
Get full text

SiameseNet based on multiple instance learning for accurate identification of the histological grade of ICC tumors by Zhizhan Fu, Fazhi Feng, Xingguang He, Tongtong Li, Xiansong Li, Jituome Ziluo, Zixing Huang, Jinlin Ye

“…BackgroundAfter hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Timely and accurate identification of ICC histological grade is critical for guiding clinical diagnosis and treatment planning.MethodWe proposed a dual-branch deep neural network (SiameseNet) based on multiple-instance learning and cross-attention mechanisms to address tumor heterogeneity in ICC histological grade prediction. …”
Get full text

Aclaraciones necesarias para el diagnóstico y organización de las causas de muerte en autopsias by José Domingo Hurtado de Mendoza Amat, Teresita de Jesús Montero González, Virginia Capó de Paz, Laura López Marín, Licet González Fabián

“…Opinión: Entre las enfermedades que se asocian con mayor frecuencia a las causas de muerte, tanto en Cuba como en el mundo, se encuentran: la aterosclerosis, la diabetes mellitus, la hipertensión arterial, el cáncer, las infecciones, las intervenciones quirúrgicas, el tromboembolismo pulmonar, la enfermedad pulmonar obstructiva crónica, los aneurismas, el shock y el daño múltiple de órganos. …”
Get full text

Novel transcripts of EMT driving the malignant transformation of oral submucous fibrosis by Smitha Sammith Shetty, Kanaka Sai Ram Padam, Mohit Sharma, Adarsh Kudva, Pratik Patel, Raghu Radhakrishnan

“…The curated EMT genes were correlated with functional cancer states and subjected to clustering to identify candidate genes. …”
Get full text

HAVCR1 Affects the MEK/ERK Pathway in Gastric Adenocarcinomas and Influences Tumor Progression and Patient Outcome by Ji Xue, Ying Li, Jianfeng Yi, Hong Jiang

“…Especially, HAVCR1 overexpression promotes the development and progression of several human cancers. Hence, we aimed to detect the effects of HAVCR1 on gastric adenocarcinoma (GAC). …”
Get full text

DDX24 promotes lymphangiogenesis and lymph node metastasis via AGRN production in cervical squamous cell carcinoma by Baibin Wang, Yuan Zhuang, Chongrong Weng, Yanhui Jiang, Bingfan Xie, Lijie Wang, Yingying Dong, Xiangpei Fang, Jianzhong He, Xiaojin Wang, Huanhuan He, Yong Chen, Huilong Nie, Yanjie Yin

Get full text