Perception of the Importance of Inherited Genetics and Lifestyle on the Development of Chronic Diseases: A UK Cross‐Sectional Survey by Aamir Hussain, Lourdes Santos‐Merx, Mariasole Da Boit

“…Moreover, the majority of the respondents chose lifestyle over inherited genes as most important factor for cancer, cardiovascular disease and Type 2 Diabetes development (50.8% vs. 29.6%, 79% vs. 11.9%, 85.7% vs. 9.6%; respectively), while 60.6% of respondents selected inherited genes for rheumatoid arthritis (p < 0.05). …”
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The Kidney Transplant Evaluation Process in the Elderly: Reasons for Being Turned down and Opportunities to Improve Cost-Effectiveness in a Single Center by Beatrice P. Concepcion, Rachel C. Forbes, Aihua Bian, Heidi M. Schaefer

“…After adjustment for patient demographics and comorbid conditions, history of CAD, PVD, or both (OR = 1.75, 95% CI (1.20, 2.56), p=0.004), chronic obstructive pulmonary disease (OR = 8.75, 95% CI (2.81, 27.20), p=0.0002), and cancer (OR 2.59, 95% CI (1.18, 5.67), p=0.02) were associated with a higher risk of being turned down. 14.8% of patients underwent unnecessary basic testing and 9.6% underwent unnecessary supplementary testing with the charges over a 3-year period estimated at $304,337. …”
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Oropharyngeal Dysphagia Patient Profile Based on Flexible Endoscopic Evaluation of Swallowing by Chairul Anhar, Rizka Fathoni Perdana, Mohd Razif Mohamad Yunus

“…The prevalence of oropharyngeal dysphagia is higher when there is the presence of comorbid conditions such as head-and-neck cancer (19%–81%) and neurological diseases (Parkinson’s [80%–100%] and stroke [19%–81%]). …”
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C-reactive protein as a diagnostic marker for ovarian carcinoma by Angga Dewi Umar Wahyu, Syahrul Rauf, Susiawaty Susiawaty, Maisuri T. Chalid, Nugraha Utama Pelupessy, Irma Savitri

“… Ovarian carcinoma is a leading cause of death in gynecological cancers, making early detection crucial for improving survival rates. …”
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Melanoma Mimicking Malignant Peripheral Nerve Sheath Tumor with Spread to the Cerebellopontine Angle: Utility of Next-Generation Sequencing in Diagnosis by Katie Fox Hanson, Paul Birinyi, Ronald Walker, Constantine Raptis, Rebecca Chernock, Jeroen Coppens, Katherine E. Schwetye

“…Next-generation sequencing of a panel of cancer-associated genes demonstrated 19 identical, clinically significant mutations as well as a high tumor mutation burden in both the parotid-region and CP angle tumors, indicating a metastatic relationship between the two and a melanocytic identity of the parotid-region tumor.…”
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Efficacy and safety of immunotherapy for head and neck squamous cell carcinoma: a meta-analysis of randomized clinical trials by Cailing Jiang, Shuqin Wang, Lijun Zhu

“…BackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most common types of cancer worldwide and immune checkpoint inhibitors have shown favorable therapeutic effects in recurrent or metastatic or locally advanced head and neck squamous cell carcinoma (R/M/LA HNSCC). …”
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Free radicals and their impact on health and antioxidant defenses: a review by Nisansala Chandimali, Seon Gyeong Bak, Eun Hyun Park, Hyung-Jin Lim, Yeong-Seon Won, Eun-Kyung Kim, Sang-Ik Park, Seung Jae Lee

“…Chronic conditions such as cancer, cardiovascular diseases, neurodegenerative disorders, and inflammatory diseases have been strongly associated with the harmful effects of free radicals. …”
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Annotation-free deep learning for predicting gene mutations from whole slide images of acute myeloid leukemia by Bo-Han Wei, Xavier Cheng-Hong Tsai, Kuo-Jui Sun, Min-Yen Lo, Sheng-Yu Hung, Wen-Chien Chou, Hwei-Fang Tien, Hsin-An Hou, Chien-Yu Chen

“…Despite the demonstrated potential for characterizing gene mutations directly from WSIs in certain cancers, challenges remain due to image resolution and reliance on manual annotations for acute myeloid leukemia (AML). …”
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Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma by Zhengyan Li, Wei Chen, Shu Yao, Zuxiang Peng, Hongming Liu, Yongliang Tang, Yi Feng

“…We utilized non-negative matrix factorization (NMF) clustering to identify mitophagy patterns in HCC TME cells, including cancer-associated fibroblasts (CAFs), T cells, B cells, and tumor-associated macrophages (TAMs). …”
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Multiple Group Testing Procedures for Analysis of High-Dimensional Genomic Data by Hyoseok Ko, Kipoong Kim, Hokeun Sun

“…Also, we applied all methods considered in simulation studies to identify genes associated with ovarian cancer from over 20,000 genetic sites generated from Illumina Infinium HumanMethylation27K Beadchip. …”
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To study the expression of estrogen, progesterone receptor and p53 immunohistochemistry markers in subtyping endometrial carcinoma by Anuja Yadav, Anuradha Sistla, Meenakshi Swain, Swarnalata Gowrishankar, Michelle de Padua, Tejal Modi, Rallabandi Himabindu, Neha Agarwal, Aditya Kulkarni, Trilok Bhandari, Hemanth Vudayaraju, Chinnababu, Vijay A. Reddy

“…Background: Endometrial cancer is one of the most commonly diagnosed cancers in women worldwide. …”
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Classification of Thyroid Nodules with Stacked Denoising Sparse Autoencoder by Zexin Li, Kaiji Yang, Lili Zhang, Chiju Wei, Peixuan Yang, Wencan Xu

“…The classifier performed well in discriminating malignant and benign thyroid nodules, with an area under the curve of 0.785 [0.638–0.931], accuracy of 92.9% [92.7–93.0%], sensitivity of 98.6% [95.9–101.3%], specificity of 58.3% [30.4–86.2%], positive likelihood ratio of 2.367 [1.211–4.625], and negative likelihood ratio of 0.024 [0.003–0.177]. In the cancer prevalence range of 20–40% for indeterminate thyroid nodules in cytology, the range of negative predictive value of this classifier was 37–61%, and the range of positive predictive value was 98–99%. …”
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A novel approach to earlobe reconstruction using the V to Y advancement flap by Laura Allen, Kelti Munroe, S. Mark Taylor

“…All patients had a non-melanoma skin cancer involving the earlobe. All surgeries were performed under local anesthetic at a tertiary care centre in Halifax, Canada. …”
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Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration by Junyu Zhang, Yu Zhou

“…Furthermore, several significantly enriched biological processes, including cancer, organismal injury and abnormalities, and ophthalmic disease, were identified associated with these DEGs. …”
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Oral manifestations of multiple myeloma – A systematic review by Padmajaa Krishnan, Madhu Narayan, Bose Divya, T Dinesh Kumar, A Ramesh Kumar, Rajkumar Krishnan

“…The mortality rate of MM accounts for 1 % of all cancer death globally. Pertaining to oral cavity 35 % of patients with symptomatic MM present with lytic bone lesions of jaws. …”
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A Review of Caveats in Statistical Nuclear Image Analysis by Helene Schulerud, Gunner B. Kristensen, Knut Liestøl, Liljana Vlatkovic, Albrecht Reith, Fritz Albregtsen, Hàvard E. Danielsen

“…The present article discusses some of the difficulties in statistical evaluation of nuclear image analysis, and a study of cervical cancer is presented in order to illustrate the problems. …”
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Can Primary Cardiac Myxofibrosarcoma Grow Quickly from Zero to a Size Leading to Left-Sided Heart Failure within 9 Months? by Levan Karazanishvili, Eduard Limonjiani

“…The following pathologic diagnosis was finally made: myxofibrosarcoma, FNCLCC (National Federation of Cancer Centres) Grade 2. Immunohistochemistry showed positivity for Epithelial membrane antigen (EMA), desmin, calretinin, Ki67, Smooth Muscle Actin (SMA), and S100. …”
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Use of Hospital Patient and Family Advisory Councils: A Scoping Study by Barbara Lewis MBA, Chris Cochran PhD, Erika Marquez PhD, MPH, Neeraj Bhandari PhD, Jennifer Pharr PhD, Soumya Upadhyay PhD, Stowe Shoemaker PhD

“…Of the articles about specific PFACs, 70% either dealt with a condition, such as cancer, the type of person, such as youth, or both. …”
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The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver by Indra Radek, Jelínková Sandra, Kollárová Katarína, Zahumenská Petra, Dvořák Josef, Dušková Šárka, Dračínská Helena

“…Lenvatinib is an orally effective tyrosine kinase inhibitor used to treat several types of tumors, including progressive, radioiodine-refractory differentiated thyroid cancer and advanced renal cell carcinoma. Although this drug is increasingly used in therapy, its metabolism and effects on the organism are still not described in detail. …”
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The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas by Bac Thanh Nguyen, Duc Anh Tran, Hung Quang Ngo, Trung Hoang Nguyen, Hoa Khanh Ngo

“…Methods: The study was conducted by descriptive method, on 52 high-grade gliomas patients at Vietnam National Cancer Hospital, from January 2019 to December 2020. …”
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