TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies by Wolfgang Eberhardt, Usman Nasrullah, Josef Pfeilschifter

“…Therapy resistance still constitutes a common hurdle in the treatment of many human cancers and is a major reason for treatment failure and patient relapse, concomitantly with a dismal prognosis. …”
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ARE QUALITY INDICATORS IMPORTANT IN COLONOSCOPIES? ANALYSIS OF 3,076 EXAMS IN A PRIVATE TERTIARY SERVICE IN SOUTHEASTERN BRAZIL by Adriana Borgonovi CHRISTIANO, Danielle Rossana Queiroz Martins BONILHA, Mauro Augusto MARCHIORI JUNIOR, Priscilla de Sene Portel OLIVEIRA, Maria de Lourdes Setsuko AYRIZONO

“…ABSTRACT BACKGROUND: The carcinogenesis of colorectal cancer is well understood. Adenomas are the precursor lesions in about 70% of cases, highlighting the importance of screening programs. …”
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Potential Role of African Fermented Indigenous Vegetables in Maternal and Child Nutrition in Sub-Saharan Africa by Marie Lys Irakoze, Eliud N. Wafula, Eddy Owaga

“…It can also increase bioavailability of various vitamins, minerals, and phytochemicals and increase synthesis of vital blood pressure regulators thus protecting against cardiovascular diseases and cancer and further helping fight certain malnutrition deficiencies. …”
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A Novel Approach for the Enumeration of Peripheral Blood Stem Cells Suitable for Transplantation by Winston Costa Pereira, Omar Alsuhaibani, Ghaleb Elyamany, Abdulaziz Al Abdulaaly

“…These well-characterized stem cells are clinically relevant in the treatment of diseases such as breast cancer, leukemias, and congenital immunodeficiencies. …”
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Role of Age and Sex on the Incidence of Leukemia in a Sample of Iraqi Patients by Dahlia N. AL-Saidi

“…Background: Leukemia accounts for 8% of the total cancers in the population and is known as the world’s fifth most common type. …”
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Identifying ADME-related gene signature for immune landscape and prognosis in KIRC by single-cell and spatial transcriptome analysis by Hongyun Wang, Feizhou Li, Qiong Wang, Xinyuan Guo, Xinbing Chen, Xinrong Zou, Jun Yuan

“…Abstract Kidney renal clear cell carcinoma (KIRC) is the most prevalent subtype of kidney cancer. Although multiple therapeutic agents have been proven effective in KIRC, their clinical application has been hindered by a lack of reliable biomarkers. …”
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Intra-Abdominal Bleeding during Pregnancy, Preterm Delivery, and Placental Polyp in a Long-Term Survivor of Neuroblastoma: A Case Report by Noriyoshi Watanabe, Junna Tsutsui, Satsuki Kakiuchi, Seung Chik Jwa, Hironori Takahashi, Naomi Kato, Nobuaki Ozawa, Haruhiko Sago, Michihiro Kitagawa

“…She also had a placental polyp and developed massive postpartum bleeding. Conclusion. Cancer treatment, especially radiation therapy, in childhood may cause adverse outcomes during pregnancy in long-term survivors of neuroblastoma.…”
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Mining the Proteome of subsp. ATCC 25586 for Potential Therapeutics Discovery: An Approach by Abdul Musaweer Habib, Md. Saiful Islam, Md. Sohel, Md. Habibul Hasan Mazumder, Mohd. Omar Faruk Sikder, Shah Md. Shahik

“…In this study, we adopted subtractive genomics approach to analyze the whole genome sequence of the Fusobacterium nucleatum, a human oral pathogen having association with colorectal cancer. Our study divulged 1,499 proteins of F. nucleatum, which have no homolog's in human genome. …”
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MobileNet-HeX: Heterogeneous Ensemble of MobileNet eXperts for Efficient and Scalable Vision Model Optimization by Emmanuel Pintelas, Ioannis E. Livieris, Vasilis Tampakas, Panagiotis Pintelas

“…MobileNet-HeX is benchmarked against state-of-the-art vision models in challenging case studies, such as skin cancer classification and deepfake detection. The results demonstrate that MobileNet-HeX not only surpasses these models in performance but also excels in speed and memory efficiency. …”
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Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults by Anna Koumarianou, Panagiota Oikonomopoulou, Margarita Baka, Dimitrios Vlachodimitropoulos, Stylianos Argentos, Theodoros Piperos, Maria-Ioanna Christodoulou, Kakoulis Theodoulou, Theodoros Mariolis-Sapsakos

“…MYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms’ tumor, and small cell lung cancer. While neuroblastoma is one of the most common childhood malignancies, in adults it is extremely rare and its treatment is based on pediatric protocols that take into consideration stage and genotypic features, such as MYCN amplification. …”
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A Robust Hybrid Approach Based on Estimation of Distribution Algorithm and Support Vector Machine for Hunting Candidate Disease Genes by Li Li, Hongmei Chen, Chang Liu, Fang Wang, Fangfang Zhang, Lihua Bai, Yihan Chen, Luying Peng

“…We have benchmarked the method using the microarray data of both diffuse B cell lymphoma and colon cancer to demonstrate its performance for identifying key features from the profile data of high-dimension gene expression. …”
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Differences in risk factor profiles for peripheral artery disease compared to coronary, cerebral and carotid artery by Stefan Acosta, Yufeng Du, Yan Borné, Anders Gottsäter

“…Abstract The aim of this study was to evaluate the greatest drivers for development of lower extremity peripheral artery disease (PAD) in relation to coronary, precerebral, or cerebral artery disease This prospective study (Malmö Diet and Cancer study) included 26,681 participants. The diagnosis of incident PAD, coronary artery disease (CoAD), atherothrombotic ischemic stroke (IS) free from atrial fibrillation or flutter, and carotid artery disease (CaAD) was validated. …”
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Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFβ3 and Induces a Myofibroblast-Like Genotype by Luisa Marilena Schäck, Manuela Buettner, Alexander Wirth, Claudia Neunaber, Christian Krettek, Andrea Hoffmann, Sandra Noack

“…The protein CD24 has been reported to be involved in a diverse range of processes such as cancer, adaptive immunity, inflammation, and autoimmune diseases in other cell types. …”
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Barriers to uptake of harm reduction techniques for GBMSM who use drugs in night-clubs and sex-on-premises venues in London and the Southeast: a mixed-methods, qualitative study by Stephen Naulls, K. Oniti, J. Eccles, J. M. Stone

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Increase in assisted suicide in Switzerland: did the socioeconomic predictors change? Results from the Swiss National Cohort by Marcel Zwahlen, Nicole Steck, Christoph Junker

“…Crude rates of assisted suicide more than tripled during the study period from 3.60 to 11.21 per 100 000 person-years; the increase was more pronounced in the older age group. Cancer was the most common underlying diagnosis (41.8%), but the percentage dying assisted was highest among patients with diseases of the nervous system (5.25% in the younger and 1.23% in the older age group). …”
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Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma by Jeffrey M. Grimes, Sadashib Ghosh, Shamza Manzoor, Li X. Li, Monica M. Moran, Jennifer C. Clements, Sherrie D. Alexander, James M. Markert, Jianmei W. Leavenworth

“…Abstract Oncolytic viruses (OVs) emerge as a promising cancer immunotherapy. However, the temporal impact on tumor cells and the tumor microenvironment, and the nature of anti-tumor immunity post-therapy remain largely unclear. …”
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Progesterone Increases Apoptosis and Inversely Decreases Autophagy in Human Hepatoma HA22T/VGH Cells Treated with Epirubicin by Wen-Tsan Chang, Hsiao-Ling Cheng, Bau-Shan Hsieh, Chien-Chih Chiu, King-Teh Lee, Kee-Lung Chang

“…Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. Epirubicin can induce intracellular reactive oxygen species and is widely used to treat unresectable HCC. …”
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Synthesis, antiproliferative and antiplasmodial evaluation of new chloroquine and mefloquine-based harmiquins by Pavić Kristina, Poje Goran, Carvalho Lais Pessanha De, Held Jana, Rajić Zrinka

“…Here we present the synthesis and evaluation of the biological activity of new hybrid compounds, ureido-type (UT) harmiquins, based on chloroquine (CQ) or mefloquine (MQ) scaffolds and β-carboline alkaloid harmine against cancer cell lines and Plasmodium falciparum. The hybrids were prepared from the corresponding amines by 1,1′-carbonyldiimidazole (CDI)-mediated synthesis. …”
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The Anti-Inflammatory Effect of Callicarpa nudiflora Extract on H. Pylori-Infected GES-1 Cells through the Inhibition of ROS/NLRP3/Caspase-1/IL-1β Signaling Axis by Lili Li, Bo Bao, Xingxing Chai, Xiaoyu Chen, Xiaohua Su, Shixiu Feng, Xiaohui Zhu

“…Helicobacter pylori (H. pylori) is the main pathogenic factor of gastric cancer, chronic gastritis, and other gastric diseases. …”
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Clinical Practice of Endoscopic Submucosal Dissection for Early Colorectal Neoplasms by a Colonoscopist with Limited Gastric Experience by Wen-Hsin Hsu, Meng-Shun Sun, Hoi-Wan Lo, Ching-Yang Tsai, Yu-Jou Tsai

“…The implementation of colorectal ESD in countries where early gastric cancer is uncommon might therefore be difficult. The aim is to delineate the feasibility and the learning curve of colorectal ESD performed by a colonoscopist with limited experience of gastric ESD. …”
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