siRNA therapeutics for effective management of rheumatoid arthritis by Vishakha R. Chakole, Tathagata Dutta, Priyankar Sen

“…This property makes siRNA a valuable tool for developing RNAi therapeutics, particularly for managing conditions like osteoporosis, cancer, genetic disorders, and autoimmune disorders. …”
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Artificial Neural Network-Based System for PET Volume Segmentation by Mhd Saeed Sharif, Maysam Abbod, Abbes Amira, Habib Zaidi

“…Experimental and Monte Carlo simulated PET phantom data sets and clinical PET volumes of nonsmall cell lung cancer patients were utilised to validate the proposed algorithm which has demonstrated promising results.…”
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The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background by Jinsheng Yu, Sharon Marsh, Junbo Hu, Wenke Feng, Chaodong Wu

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and it comprises a spectrum of hepatic abnormalities from simple hepatic steatosis to steatohepatitis, fibrosis, cirrhosis, and liver cancer. While the pathogenesis of NAFLD remains incompletely understood, a multihit model has been proposed that accommodates causal factors from a variety of sources, including intestinal and adipose proinflammatory stimuli acting on the liver simultaneously. …”
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Interaction studies unveil potential binding sites on bovine serum albumin for gut metabolite trimethylamine n-oxide (TMAO) by Awadhesh Kumar Verma, Payal Gulati, GBVS Lakshmi, Anand Mohan, Neeta Raj Sharma, Pratima R. Solanki, Anil Kumar

“…Abstract Trimethylamine-N-oxide (TMAO) is gut microbiota-derived metabolite, plays a critical role in human health and diseases such as metabolic, cardiovascular, colorectal cancer and, neurological disorders. Binding interactions between TMAO and serum albumins are crucial to understand the impact of TMAO on disease mechanisms. …”
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Transmembrane and Ubiquitin-Like Domain-Containing 1 Promotes Glioma Growth and Indicates Unfavorable Prognosis by Yinggang Liu, Changcheng Cai, Ke Wu, Libo Hu

“…We conducted a comprehensive analysis using two cohorts: a retrospective glioma cohort from our hospital and The Cancer Genome Atlas (TCGA) cohort. The mRNA levels of TMUB1 were assessed through reverse transcription-quantitative polymerase chain reaction (RT-qPCR). …”
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Tortuous Common Carotid Artery: A Report of Four Cases Observed in Cadaveric Dissections by Joe Iwanaga, Koichi Watanabe, Saga Tsuyoshi, Yoko Tabira, Koh-ichi Yamaki

“…Case 3 was an 86-year-old woman who died from bladder cancer and who also had a right tortuous common carotid artery without arteriosclerosis. …”
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Integrating Knowledge Graphs with Symbolic AI: The Path to Interpretable Hybrid AI Systems in Medicine by Maria-Esther Vidal, Yashrajsinh Chudasama, Hao Huang, Disha Purohit, Maria Torrente

“…This position paper examines the challenges and research opportunities in integrating KGs with neuro-symbolic AI, highlighting their potential to enhance explainability, scalability, and context-aware reasoning in hybrid AI systems. Using a lung cancer use case, we illustrate how hybrid approaches address tasks such as link prediction—uncovering hidden relationships in medical data—and counterfactual reasoning—analyzing alternative scenarios to understand causal factors. …”
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The AST/ALT (De Ritis) ratio as a significant prognostic factor in myelodysplastic syndrome by Ying Chen, Yue Wu, Ting Chen, Duobing Zou, Cong Shi, Ningning Wu, Lixia Sheng, Guifang Ouyang, Qitian Mu

“…Background: The aspartate transaminase (AST)/alanine transaminase (ALT) ratio, also termed the De Ritis ratio, has been demonstrated to have an association with poor prognosis in several cancer types. However, its prognostic value in patients with myelodysplastic syndrome (MDS) remains unclear. …”
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Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats by Salah M. Aly, Hamdy A. Fetaih, Abeer A. I. Hassanin, Mosleh M. Abomughaid, Aliaa A. Ismail

“…The HCC-induced group showed histopathological features of liver cancer including hypercellularity, nuclear hyperchromasia, mitotic figures, and preneoplastic foci. …”
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Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone by Shachar Kenan, Leonard Kahn, Morris Edelman, Arlene Redner, Samuel Kenan

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Young Cuban Patients with a Clinical and biochemical Diagnosis of Xeroderma Pigmentosum by Judith Beatriz Pupo Balboa, Mónica Marín García, Anamarys Pandolfi Blanco, Lucía Fariñas Rodríguez, Paulina Araceli Lantigua Cruz

“…<strong>Foundation:</strong> skin cancer is a complication of xeroderma pigmentosum; early diagnosis is important. …”
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A Rare Case of Grey Zone Lymphoma Successfully Treated with Brentuximab Vedotin and R-CHP Chemotherapy by Rajiv M. Mallipudi, Lance Alquran, Vishnu A. Shenoy, Lori A. Leslie, John A. Conti

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Strategies to Identify Recognition Signals and Targets of SUMOylation by Elisa Da Silva-Ferrada, Fernando Lopitz-Otsoa, Valérie Lang, Manuel S. Rodríguez, Rune Matthiesen

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In Vitro Sustained Release Study of Gallic Acid Coated with Magnetite-PEG and Magnetite-PVA for Drug Delivery System by Dena Dorniani, Aminu Umar Kura, Samer Hasan Hussein-Al-Ali, Mohd Zobir Bin Hussein, Sharida Fakurazi, Abdul Halim Shaari, Zalinah Ahmad

“…Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG.…”
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Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy by Yuting Xie, Ze Yang, Hang Shen, Jingyi Chen, David A. Weitz, Dong Chen, Jianpeng Sheng, Tingbo Liang

“…Abstract Chemotherapy is an effective option for cancer treatment. However, its clinical application is often limited by the severe side effects of chemical drugs. …”
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Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients by Dongxue Zhang, Xin Liu, Bojun Wei, Guoliang Qiao, Tao Jiang, Zhenwen Chen

“…Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown. …”
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The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s by Lilin Gan, Wenzheng Luo, Qian Cheng, Shanke Wan, Min Wu, Mingqi Wang, Enming Luo, Xianjin Luo, Shuo Li

“…The human C-MYC promoter and telomere G4 DNA structures were widely recognized as promising targets for cancer therapy. Nevertheless, the effectiveness of the traditional small-molecule fluorescent probe targeting G4 was hindered by limitations in single function and low selectivity, and progress in anti-tumor research was impeded. …”
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Presegmenter Cascaded Framework for Mammogram Mass Segmentation by Urvi Oza, Bakul Gohel, Pankaj Kumar, Parita Oza

“…Accurate segmentation of breast masses in mammogram images is essential for early cancer diagnosis and treatment planning. Several deep learning (DL) models have been proposed for whole mammogram segmentation and mass patch/crop segmentation. …”
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Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis by Chong-Un Cheong, Ching-Ping Chang, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang, Chung-Ching Chio

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Heme alters biofilm formation in Mycobacterium abscessus by Hadia Aftab, Jessica Samudio, Grace Wang, Lily Le, Rajesh K. Soni, Rebecca K. Donegan

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