Rapid Identification and Systematic Mechanism of Flavonoids from Potentilla freyniana Bornm. Based on UHPLC-Q-Exactive Orbitrap Mass Spectrometry and Network Pharmacology by Wei Cai, Kailin Li, Shihan Qin, Pei Xiong, Jie Peng, Silin Shi, Zaiqi Zhang

“…This finding revealed that P. freyniana possessed 43 flavonoids (40 of them were first reported) with 23 core target genes, which are associated with PI3K-Akt, MAPK, TNF signaling pathway, and pathway in cancer. This study demonstrated the multicompound, multitarget, and multimechanism of P. freyniana, which are very beneficial to develop the further study and utilization of this plant including the material basis and quality control research.…”
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Plant thionins: structure, biological functions and potential use in biotechnology by T. I. Odintsova, M. P. Slezina, E. A. Istomina

“…Thionins are toxic to different types of cells including mammalian cancer cell lines. Transgenic plants expressing thionin genes display enhanced resistance to pathogens. …”
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Comparison of ropivacaine with ropivacaine–dexamethasone combination for postoperative analgesia in the pectoral nerve block for modified radical mastectomy: A randomized clinical... by Veena Mathur, Brijesh Kumari, Anand Kumar Verma, Arvind Khare, Deepak Kumar Garg

“…Methods: This prospective, randomized, double-blind study was conducted on a total of 80 women with breast cancer belonging to American Society of Anesthesiologist class I and II scheduled for MRM, which were randomly allocated into two groups – Group R (n = 40) received 0.25% ropivacaine 29 ml + NS 1 ml and Group RD (n = 40) received 0.25% ropivacaine 29 ml + dexamethasone (4 mg) 1 ml. …”
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Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature by Weiming Wang, Baogang Zhang, Zhangli Wu, Chuanling Hou, Mengyao Li, Tianyi Zhang

“…There have been similar cases reported before, involving a 57-year-old male-patient (Sahetia et al. in Ind J Cancer 60:575–577, 2023).…”
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Myeloperoxidase Promoter Polymorphism −463G Is Associated With More Severe Clinical Expression of Cystic Fibrosis Pulmonary Disease by Wanda F. Reynolds, Isabelle Sermet-Gaudelus, Valérie Gausson, Marie-Noëlle Feuillet, Jean-Paul Bonnefont, Gérard Lenoir, Béatrice Descamps-Latscha, Véronique Witko-Sarsat

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Clinical benefits of the 5th intercostal incision in uniportal VATS for female patients by Dalin Wang, Zhilin Luo, Jia Ming

“…A retrospective analysis of 150 female lung cancer patients was conducted, divided into 4 and 5th intercostal incision groups (n = 75 each). …”
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Medullary breast carcinoma: a pathogenic review and immunohistochemical study using tissue microarray by Ming Lee, Ana Richelia Jara-Lazaro, Poh Yian Cheok, Aye Aye Thike

“…Presence of lymphovascular invasion and nodal stage were significantly correlated with recurrence and breast cancer-related deaths, respectively. ER negativity was significantly correlated with triple positivity for basal markers CK14, EGFR and 34BE12, which comprised patients who showed a significantly decreased disease-free survival rate within a 10–15-year follow-up period. …”
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Lipid Rafts in Signalling, Diseases, and Infections: What Can Be Learned from Fluorescence Techniques? by Sara Anselmo, Elisa Bonaccorso, Chiara Gangemi, Giuseppe Sancataldo, Valeria Conti Nibali, Giovanna D’Angelo

“…Their essential role is claimed in both physiological and pathological conditions, including cancer, neurodegenerative diseases, and viral infections, making them a key area of research. …”
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Prediction of early postoperative recurrence of hepatocellular carcinoma by habitat analysis based on different sequence of contrast-enhanced CT by Yubo Zhang, Yubo Zhang, Hongyan Ma, Peng Lei, Zhiyuan Li, Zhao Yan, Xinqing Wang

“…Machine learning classification models were constructed as a fusion model combining the three different models, and the models were assessed.ResultsA comprehensive retrospective analysis was conducted on a cohort of 344 patients who underwent hepatic cancer resection at one of the two centers. it was found that the combined SVM model yielded superior results after comparing various metrics, such as the AUC, accuracy, sensitivity, specificity, and DCA.ConclusionsHabitat analysis of sequential CT images can delineate distinct subregions within a tumor, offering valuable insights for early prediction of postoperative HCC recurrence.…”
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Active surveillance for adult low-risk papillary thyroid microcarcinoma—a review focused on the 30-year experience of Kuma Hospital— by Yasuhiro Ito, Akira Miyauchi, Makoto Fujishima, Masashi Yamamoto, Takahiro Sasaki

“…Active surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. …”
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A single-site randomized controlled trial of partner navigation to HCV treatment for people who inject drugs: a study protocol for the You’re Empowered for Treatment Initiation (YE... by Meghan D. Morris, Judy Y. Tan, Claire C. McDonell, Maia Scarpetta, Tiffany N. Nguyen, Jennifer C. Price, Torsten B. Neilands

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Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia by M. Carmen Jiménez-López, Ana Carolina Moreno-Maldonado, Natividad Martín-Morales, Francisco O’Valle, M. Ricardo Ibarra, Gerardo F. Goya, Ignacio J. Molina

“…Abstract There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41 °C. …”
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Effects of Permissive Hypercapnia on Laparoscopic Surgery for Rectal Carcinoma by Lei Wang, Lina Yang, Jing Yang, Shiqiang Shan

“…Permissive hypercapnia with a PaCO2 level of 56-65 mmHg was able to improve respiratory function after laparoscopic surgery in rectal cancer patients.…”
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Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells by Bernard Owusu Asimeng, Emmanuel Nyankson, Johnson Kwame Efavi, Amartey Nii Amarkai, Gloria Pokuaa Manu, Elvis Tiburu

“…The findings show that the particles have a different inhibitory mechanism on HeLa cells ion transfer and are promising to be further exploited for cancer treatment.…”
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A multiscale model for glioma spread including cell-tissue interactions and proliferation by Christian Engwer, Markus Knappitsch, Christina Surulescu

“…Our current accounting for two subpopulations of cells to accomodate proliferation according to the go-or-grow dichtomotyis an extension of the setting in [16].As in that paper, we assume that cancer cells use neuronal fiber tracts as invasive pathways. …”
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A prospective, multicenter analysis of the integrated 31-gene expression profile test for sentinel lymph node biopsy (i31-GEP for SLNB) test demonstrates reduced number of unnecess... by J. Michael Guenther, Andrew Ward, Brian J. Martin, Mark Cripe, Rohit Sharma, Stanley P. Leong, Joseph I. Clark, John Hamner, Timothy Beard

“…Abstract Background National Comprehensive Cancer Network guidelines recommend sentinel lymph node biopsy (SLNB) for patients with > 10% risk of positivity, consider SLNB with 5–10% risk, and foregoing with < 5% risk. …”
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Homeopathic Preparations to Control the Rosy Apple Aphid (Dysaphis plantaginea Pass.) by Eric Wyss, Lucius Tamm, Joachim Siebenwirth, Stephan Baumgartner

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Why Are Native Hawaiians Underrepresented in Hawai‘i's Older Adult Population? Exploring Social and Behavioral Factors of Longevity by Lana Sue Ka‘opua, Kathryn L. Braun, Colette V. Browne, Noreen Mokuau, Chai-Bin Park

“…Findings reveal that Native Hawaiians have the largest years of productive life lost and the lowest life expectancy, when compared to the state's other major ethnic groups. Heart disease and cancer are leading causes of premature mortality. …”
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Evaluation of the Potential Prognostic Value of Tumor Budding in Laryngeal Carcinoma by Conventional and Immunohistochemical Staining by Nermine M. Abd Raboh, Ossama M. Mady, Sarah A. Hakim

“…Tumor budding is a promising prognostic indicator in several cancers especially in colorectal cancer. However, only few studies have been conducted to assess and validate its prognostic value in laryngeal squamous cell carcinoma; none of which used pancytokeratin immunohistochemistry. …”
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Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression by Shankar Suman, Wendy K. Nevala, Alexey A. Leontovich, James W. Jakub, Liyi Geng, Sarah A. McLaughlin, Svetomir N. Markovic

“…The upregulation of Th2 cytokines in cancer cells is recognized for its involvement in suppressing anticancer immunity. …”
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