Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets by Simon A. Young, John G. Mina, Paul W. Denny, Terry K. Smith

“…Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. …”
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Interference with the Autophagic Process as a Viral Strategy to Escape from the Immune Control: Lesson from Gamma Herpesviruses by Roberta Santarelli, Marisa Granato, Alberto Faggioni, Mara Cirone

“…These two viruses belong to γ-Herpesvirus subfamily and are associated with several human cancers. Besides the effects on the immune response, we have described how autophagy subversion by viruses may also concur to the enhancement of their replication and to viral tumorigenesis.…”
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Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria by Rawan Al khudari, Mohannad Homsi, Hasan Al zohaily, Maher S. Saifo

“…Bilateral breast cancers are rare cases encountered and are usually the same type in both sides. …”
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2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities by Raman Singh, Vidushi Gupta, Antresh Kumar, Kuldeep Singh

“…The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. …”
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Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development. by Theresa A Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M Pfleger

“…Inhibition of Ras, Notch, and PI3K signaling may explain why Rabex-5 is deleted in some cancers. Paradoxically, Rabex-5 is reported to be an oncogene in other cancers. …”
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Alloreactivity of Allogeneic Mesenchymal Stem/Stromal Cells and Other Cellular Therapies: A Concise Review by Kiran Shah, Nirali Shah, Fatameh Ghassemi, Carolyn Ly, Teena George, Carla Lutz, Huseyin Sumer

“…Cellular therapies, deemed live medicine, have brought a wave of new generation biological therapies to treat previously untreatable diseases such as cancers and degenerative diseases like osteoarthritis. …”
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The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

“…Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers. …”
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New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells by Lixian Lin, Zengqi Tang, Zhenrui Shi, Qing Guo, Hui Xiong

“…Although it shows promising application in many diseases, such as inflammatory diseases, hypersensitivity, autoimmune diseases, and cancers, little is known about underlying molecular. …”
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FHIT Doubts are Clear Now by Anjilna Wali

“…The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. Loss of heterozygosity at various sections of the FHIT gene and the methylation analysis of the promoter region showed that it is one of the important and preliminary genetic alterations in the cell, and its restoration in the cell line or nude mice suppresses tumorigenicity. …”
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Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases by Vivek Alaigh, Debapriya Datta

“…Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. …”
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An Unusual Cervical Mass in the Hyoid Bone: Intermediate-Grade Chondrosarcoma by Ozge Caglar, O. Karatag, A. Avci, Sefa Dereköy

“…Chondrosarcomas account for 11% of all bone cancers. Primary sites of the head and the neck include the nasal cavity, the skull base, the maxilla, the mandible. …”
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Contralateral Ovarian Metastasis of Clear-Cell Renal Carcinoma: A Rare Case Report and Review of the Literature by Fatih Uruc, Serkan Akan, Aytaç Sahin, Caglar Yildirim, Ahmet Urkmez

“…Renal cell carcinoma (RCC) constitutes 2-3% of all types of cancers. RCCs metastasize into lungs (50–60%), lymph nodes (36%), bones (30–40%), liver (30–40%), and brain (5%) in respective percentages. …”
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Radiofrequency Ablation of Thyroid Nodules: Basic Principles and Clinical Application by Ji Hoon Shin, Jung Hwan Baek, Eun Ju Ha, Jeong Hyun Lee

“…RF ablation has recently shown positive short-term results for locoregional control as well as symptom improvement in patients with recurrent thyroid cancers. This paper reviews the basic physics, indications, patient preparation, devices, procedures, clinical results, and complications of RF ablation.…”
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Role of Apoptosis in HIV Pathogenesis by Cyril Jabea Ekabe, Njinju Asaba Clinton, Eugene Kusi Agyei, Jules Kehbila

“…However, variations in apoptosis have been linked to many diseases such as cancers and chronic infections. The HIV infection has contributed to increase mortality and morbidity worldwide, predominantly through the induction of gradual depletion of CD4+ T cells. …”
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Progress on the Prevention of Esophageal Stricture after Endoscopic Submucosal Dissection by Peina Shi, Xiaoyun Ding

“…Endoscopic submucosal dissection (ESD) has been widely accepted as an effective, minimally invasive treatment for superficial esophageal cancers. However, esophageal stricture often occurs in patients with large mucosal defects after ESD. …”
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Mucosal Epithelial Jak Kinases in Health and Diseases by Narendra Kumar, Longxiang Kuang, Ryan Villa, Priyam Kumar, Jayshree Mishra

“…Mutations that abrogate Jak3 functions cause an autosomal severe combined immunodeficiency disease (SCID) while activating Jak3 mutations lead to the development of hematologic and epithelial cancers. A selective Jak3 inhibitor CP-690550 (Xeljanz) approved by the FDA for certain chronic inflammatory conditions demonstrates immunosuppressive activity in rheumatoid arthritis, psoriasis, and organ transplant rejection. …”
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Incidence and risk factors for insulinoma diagnosed in dogs under primary veterinary care in the UK by Kasper Kraai, Dan G. O’Neill, Lucy J. Davison, Dave C. Brodbelt, Sara Galac, Floryne O. Buishand

“…Additionally, being a terrier breed and being a breed predisposed to other endocrine cancers were associated with increased odds for insulinoma diagnosis. …”
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Giant Anterior Chest Wall Basal Cell Carcinoma: An Approach to Palliative Reconstruction by Pauline Joy F. Santos, Christina Prendergast, Amber Leis

“…In advanced metastatic cancers, the ultimate goals should be to avoid risk for infection and provide adequate coverage for the defect.…”
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Interferon Treatment of Multiple Pulmonary Malignancies Associated with Papilloma Virus by SL Aaron, E Wong, D Tyrrell, M Duggan, E Vallieres, L Jewell, B Romanowski

“…Over a period of four years, beginning in spring 1988, a previously healthy man developed a primary squamous cell carcinoma of the tonsil, treated with radiotherapy, followed by 10 distinct, primary bronchial squamous cell carcinomas. Four of the cancers were surgically resected, all of which were positive by hybridization for human papilloma virus (type 16). …”
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Papillary Thyroid Carcinoma with Lung Metastasis Arising from Dyshormonogenetic Goiter: A Case Report by Ersin Sukru Erden, Cenk Babayigit, Ramazan Davran, Mustafa Akin, Sinem Karazincir, Nebihe Isaogullari, Mesut Demirkose, Sebahat Genc

“…Prior radiation exposure is the best known risk factor for thyroid cancers, and papillary thyroid carcinoma (PTC) may arise from dyshormonogenetic goiter. …”
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