Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review by Jun Wang, Jun Wang, Xiaojing Li, Shuang Dong, Sheng Hu, Fengming Ran, Yu Qian

“…Lastly, the third acquired mechanism pertains to histological transformation, such as the emergence of small cell lung cancer (SCLC) clones. The transformation of pathological types has brought great confusion to the clinical diagnosis and treatment process. …”
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Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions by Yuanyuan Liu, Zerong Zhang, Xiaoyan Li, Qinghong Hu, Zhangyu Jiang, Jia Lv, Jiayi Xue, Dongyu Wang, Jianxiong Cao, Lingyu Li, Xiaowen Ou, Lijun Zhu, Zhongqiu Liu, Tao Su

“…The efflux transporters, breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 2 (MRP2) are critical regulatory molecules within the enterohepatic triple recycling pathways. …”
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Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Dose-dependent expression of PIK3CA H1047R in human cervical cancer and induced pluripotent stem cells corrupted the fidelity of growth factor-induced information transfer, with preferential amplification of epidermal growth factor receptor (EGFR) signaling responses compared to insulin-like growth factor 1 (IGF1) and insulin receptor signaling. …”
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An Optimized Protocol for Simultaneous Propagation of Patient-derived Organoids and Matching CAFs by Jenny Högström, Taru Muranen

“…Recurrent hormone receptor-positive (HR+) breast cancer is a leading cause of cancer mortality in women. …”
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Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation by Rebecca E. Graham, Runshi Zheng, Jesko Wagner, Asier Unciti-Broceta, David C. Hay, Stuart J. Forbes, Victoria L. Gadd, Neil O. Carragher

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Six events that shaped antibody approvals in oncology by Suman Paul, Suman Paul, Shibin Zhou, Shibin Zhou

“…Finally, we explore the development of ipilimumab, the first immune checkpoint-inhibiting antibody that activates the immune system to kill cancer cells, and the discovery that allowed the use of checkpoint inhibitors across all cancer types based on the presence of genetic markers. …”
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A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

“…Abstract The presence of lymph node (LN) metastases guides cancer staging and worsens prognoses. Incomplete lymphadenectomy of metastatic LNs may end up with disease recurrence, while excessive resection can result in increased postoperative complications with even no survival benefit. …”
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Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…Abstract Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel and more effective therapies than those currently available are, therefore, urgently needed. …”
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Comparison of molecular analysis results determined by next-generation sequencing to immunohistochemical indicators and clinicopathological parameters in prostate adenocarcinomas by Merve Çırak Balta, İbrahim Halil Erdoğdu, Esin Oktay, Nil Çulhac

“…Background: Prostate cancer is a common cancer in males, frequently leading to mortality. …”
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Novel Maleimide Linkers Based on a Piperazine Motif for Strongly Increased Aqueous Solubility by Martijn Dijkstra, Hemma Schueffl, Anja Federa, Caroline Kast, Alexander Unterlercher, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol

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THE GENUS AS, A POTENTIAL SOURCE OF ANTICANCER AGENT: AN UPDATED REVIEW

“… On the list of the world's most significant health problems, cancer rates are high. As a consequence, cancer  treatment is a global priority. …”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…Background: Cancer remains a significant health challenge, with increasing incidence and mortality rates attributed to lifestyle factors and environmental pollutants. …”
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Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma by Kaiqiang Chen, Jihong Chen, Yanming Cheng, Danni Hong, Cairong Hu, Penggang Bai, Jinyong Lin, Yang Yang, Xiuchun Zhang

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Morbidity and Mortality Rates from Digestive Diseases in the RF Northwestern Federal District (NWFD) and Measures to Reduce Them by Andrey Yu. Baranovsky, Alexey M. Belyaev, Elina A. Kondrashina

“…Along with a decrease in the incidence of gastric cancer, an increase in the incidence of colorectal cancer, as well as pancreatic cancer, is observed. …”
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Descriptive Analysis of Heavy Metals Content of Beef from Eastern Uganda and their Safety for Public Consumption. by Keneth Iceland, Kasozi, Paul, Bogere

“…The latter was accomplished by (i) estimating the daily intake (EDI) of each metal in the study area, (ii) modeling the non-cancer health risk using the target hazard quotient (THQ) and (iii) modeling the cancer risk using the incremental lifetime cancer risk (ILCR). …”
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Motion-tolerant 3D volumetric multimodality microscopy imaging of human skin with subcellular resolution and extended field-of-view by Zhenguo Wu, Yunxian Tian, Jianhua Zhao, Yimei Huang, Harvey Lui, Sunil Kalia, Haishan Zeng

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A three dimensional printed endobronchial stent for the treatment of a broncho-esophageal fistula by Illaa Smesseim, Sophia van Beelen, Jolanda M. van Dieren, Koen J. Hartemink, Johanna van Sandick, Jacobus A. Burgers

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Changes in faecal haemoglobin values over sequential rounds of faecal immunochemical tests (FIT) in a surveillance population by Amanda J Cross, Kate Wooldrage, Gemma Mortell, Gwen A Murphy

“…Objective Colorectal cancer (CRC) screening enables resection of polyp precursor lesions, preventing cancer or detecting it earlier. …”
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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

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Training for tomorrow: Establishing a worldwide curriculum in online adaptive radiation therapy by Meegan Shepherd, Elizabeth Joyce, Bethany Williams, Siobhan Graham, Winnie Li, Jeremy Booth, Helen A. McNair

“…This commentary discusses the implementation of online adaptive radiation therapy (oART) in cancer treatment within the context of current challenges faced by radiation therapy professionals. oART enables modifications to treatment plans based on daily imaging, enhancing target accuracy while minimising harm to surrounding organs. …”
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