Epidemiological Study of Uveal Melanoma from US Surveillance, Epidemiology, and End Results Program (2010–2015) by Yufeng Xu, Lixia Lou, Yijie Wang, Qi Miao, Kai Jin, Menglu Chen, Juan Ye

“…Uveal melanoma is the most common intraocular malignancy, and the American Joint Committee on Cancer (AJCC) changed its staging methodology from 2010, incorporating notable changes into the T-staging. …”
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Effects of message framing on self-management behaviour among patients with type 2 diabetes: a randomised controlled trial protocol by Xin Zhang, Feng Li, Hui Guo, Yue Pang, Yandi Liu, Ruitong Gao, Xiaoqian Lian, Tianyue Yu, Lanyu Zhu

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Virtual online consultations: advantages and limitations (VOCAL) study by Trisha Greenhalgh, Joe Wherton, Sara Shaw, Charles Gutteridge, Emma Byrne, Isabel Hodkinson, Shanti Vijayaraghavan, Desirée Campbell-Richards, Satya Bhattacharya, Philippa Hanson, Seendy Ramoutar, Anna Collard, Joanne Morris

“…The study is based in 2 contrasting clinical settings (diabetes and cancer) in a National Health Service (NHS) acute trust in London, UK. …”
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Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib by Tatsuya Nagano, Yoshikazu Kotani, Kazuyuki Kobayashi, Masahiro Katsurada, Yukihisa Hatakeyama, Suya Hori, Daisuke Tamura, Daisuke Kasai, Yasuhiro Funada, Yoshihiro Nishimura

“…Gefitinib was reintroduced with an intermittent treatment schedule after the transaminase levels normalized, but the patient's enzyme levels rose again, and the cancer progressed. Gefitinib was eventually replaced with erlotinib. …”
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Decellularized Liver Matrices for Expanding the Donor Pool—An Evaluation of Existing Protocols and Future Trends by Marcin Morawski, Maciej Krasnodębski, Jakub Rochoń, Hubert Kubiszewski, Michał Marzęcki, Dominik Topyła, Kacper Murat, Mikołaj Staszewski, Jacek Szczytko, Marek Maleszewski, Michał Grąt

“…Liver transplantation is the only curative option for end-stage liver disease and is necessary for an increasing number of patients with advanced primary or secondary liver cancer. Many patient groups can benefit from this treatment, however the shortage of liver grafts remains an unsolved problem. …”
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Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients by Yulu Gu, Xiaoli Liu, Yaqin Yu, Jieping Shi, Lizhe Ai, Hui Sun, Joseph Sam Kanu, Chong Wang, Yawen Liu

“…The incidence rate of papillary thyroid cancer (PTC) has increased for several decades and is higher in females than males. …”
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Standard operating procedure combined with comprehensive quality control system for multiple LC-MS platforms urinary proteomics by Xiang Liu, Haidan Sun, Xinhang Hou, Jiameng Sun, Min Tang, Yong-Biao Zhang, Yongqian Zhang, Wei Sun, Chao Liu, Urine Test Sample Working Group

“…Furthermore, we apply this SOP to hybrid benchmarking samples and clinical colorectal cancer (CRC) urinary proteome including 527 experiments. …”
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Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months by Brenda Asiimwe-Kateera, Nienke Veldhuijzen, Jean Paul Balinda, John Rusine, Sally Eagle, Joseph Vyankandondera, Julie Mugabekazi, Pascale Ondoa, Kimberly Boer, Anita Asiimwe, Joep Lange, Peter Reiss, Janneke van de Wijgert

“…We applaud the Rwandan government for having strengthened family planning and PMTCT services and for having introduced HPV vaccination in recent years, but additional work is needed to strengthen STI and HPV-related cancer screening and management in the HIV-positive population.…”
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The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family by Deyong Ge, Xinyu Xu, Liyi Fang, Huihui Tao

“…These results also highlighted significant expression differences of the manganese ion metabolism family across various cancers, including BLCA, BRCA, and COAD, with notable NUDT3 mutations enriched in these cancers. …”
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Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway by Shan Xiao, Ye Yang, Yue-Tong Liu, Jun Zhu

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Patterns of Comorbidity and Multimorbidity Among Patients With Multiple Sclerosis in a Large US Commercially Insured and Medicare Advantage Population by Dingwei Dai, Ajay Sharma, Amy L. Phillips, Carroline Lobo

“…Age-related and other comorbidities (ie, hypertension, hyperlipidemia, dyspepsia, osteoarthritis, osteoporosis, glaucoma, diabetes, cerebrovascular, cancer) were more common among patients 65 years and older Medicare Advantage (all _P_ < .0001). …”
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Silymarin as a Therapeutic Agent for Hepatocellular Carcinoma: A Multi-Approach Computational Study by Ouided Benslama, Sabrina Lekmine, Hamza Moussa, Hichem Tahraoui, Mohammad Shamsul Ola, Jie Zhang, Abdeltif Amrane

“…Background: Hepatocellular carcinoma (HCC) is a prevalent and lethal form of liver cancer with limited treatment options. Silymarin, a flavonoid complex derived from milk thistle, has shown promise in liver disease treatment due to its antioxidant, anti-inflammatory, and anticancer properties. …”
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Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences by Muriel Javier, Escorial Mónica, Margarit César, Barrachina Jordi, Carvajal Cristian, Morales Domingo, Peiró Ana M.

“…More than half of patients with opioid use disorder for chronic non-cancer pain (CNCP) reduced their dose through a progressive opioid withdrawal supported by a rotation to buprenorphine and/or tramadol. …”
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Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster by Yasaman Heidarian, Tess D. Fasteen, Liam Mungcal, Kasun Buddika, Nader H. Mahmoudzadeh, Travis Nemkov, Angelo D'Alessandro, Jason M. Tennessen

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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. Recently, we developed a novel Ir(III)-based compound, [Ir(Cp∗)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF4 or Ir-6 and assessed its effectiveness as an antiplatelet drug. …”
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Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice by Takefumi Kimura, Takero Nakajima, Yuji Kamijo, Naoki Tanaka, Lixuan Wang, Atsushi Hara, Eiko Sugiyama, Eiji Tanaka, Frank J. Gonzalez, Toshifumi Aoyama

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Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…Methods Single-cell RNA sequencing (scRNA-seq) data were downloaded from t the Tumor Immune Single-cell Hub and gene expression data were retrieved from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database. …”
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A Novel Mutation in the CYP11B1 Gene Causes Steroid 11β-Hydroxylase Deficient Congenital Adrenal Hyperplasia with Reversible Cardiomyopathy by Mohammad A. Alqahtani, Ayed A. Shati, Minjing Zou, Ali M. Alsuheel, Abdullah A. Alhayani, Saleh M. Al-Qahtani, Hessa M. Gilban, Brain F. Meyer, Yufei Shi

“…Interestingly, a somatic mutation at the same codon (c.779 G>A, p.W260∗) was reported in a patient with papillary thyroid cancer (COSMIC database). In conclusion, we have identified a novel nonsense mutation in the CYP11B1 gene that causes classic steroid 11β-hydroxylase deficient CAH. …”
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Phytochemical Profile and Antioxidant Activity of Nigella sativa L Growing in Morocco by Salima Tiji, Ouijdane Benayad, Mohamed Berrabah, Ibrahim El Mounsi, Mostafa Mimouni

“…Nigella sativa L (NS) is a powerful antioxidant and medicinal plant with many therapeutic applications particularly in traditional medicine for respiratory, gastrointestinal, rheumatic, and inflammatory disorders, as well as cancer. Objective. The aim of this study is to extract the active ingredients from the Moroccan Nigella sativa L and determine its antioxidant properties. …”
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Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases by Lixin Liu, Siwen Chen, Yantao Song, Longwei Cui, Yiman Chen, Jiangli Xia, Yibo Fan, Liqun Yang, Lina Yang

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