Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

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Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies by Elisa Monti, Clara Vianello, Ilaria Leoni, Giuseppe Galvani, Annalisa Lippolis, Federica D’Amico, Sara Roggiani, Claudio Stefanelli, Silvia Turroni, Francesca Fornari

“…The development of safe and effective strategies that target the gut–liver axis holds promise for liver cancer prevention and treatment, especially if personalized options will be considered.…”
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Twelve barriers to COPD diagnosis in France: a comparative qualitative study by Maxime Patout, Laurie Fraticelli, Maéva Zysman, Olivier Le Rouzic, Elisabetta Scanferla, Clémence Martin, Mathieu Delorme, Cécilia Nocent-Ejnaini, Guillaume Roucoux, Lize Kiakouama Maleka, Annaig Ozier, Yassine Benarbia, Lize Kiakouama, Olivier Le Rouzic, Jean-Paul Vasseur, Marie-Agnès Wiss-Laurent, Carla Zonca, Nissrine Erraji, Matthieu Chanard, Fabienne Peretz, Catherine Beseme, Antonio Correira Dos Santos, Héla Saïdi, Lynda Saïl

“…The article respects the consolidated criteria for reporting qualitative research guidelines.Results Three phases in the patients’ clinical pathway to diagnosis and 12 barriers were found: Phase 1 (symptoms before consultation; n=4), lack of COPD knowledge, symptom denial, fear of lung cancer, and delayed general practice consultations; Phase 2 (primary care; n=3), letting bronchitis become chronic, priority to diseases with similar symptoms and/or more serious diseases, lack of COPD screening devices, time and curative treatments; Phase 3 (specialised medicine; n=5), treatment before diagnosis, late referral to pulmonologists, difficulty in accessing specialists and examination results, patient’s reluctance to undergo further examinations, and need for additional tests to confirm a diagnosis.Conclusion People unaware of their COPD condition can encounter up to 12 barriers, which may combine before obtaining a formal diagnosis. …”
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Cooccurrence of Metastatic Papillary Thyroid Carcinoma and Salmonella Induced Neck Abscess in a Cervical Lymph Node by Jae-Myung Kim, Ju-Yeon Kim, Eun Jung Jung, Eun Jin Song, Dong Chul Kim, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee, Soon-Chan Hong, Sang-Kyung Choi, Woo-Song Ha

“…Cystic lesions in lymph nodes with metastatic cancer may indicate the presence of cooccurring bacterial infection. …”
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Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy by Wassapol Sornthai, Achiraya Teyateeti, Tawatchai Taweemonkongsap, Siros Jitpraphai, Varat Woranisarakul, Kantima Jongjitaree, Katunyou Mahamongkol, Nattaporn Wanvimolkul, Thitipat Hansomwong

“…Abstract This study aimed to investigate the role of myosteatosis, sarcopenia, and perioperative serum biomarkers as independent predictors of major complications within 180 days following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). We retrospectively analyzed of 127 MIBC patients who underwent RC between 2013 and 2023 at a single institution. …”
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The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia by Ilia Beliakov, Maria Senina, Yuriy Tyulenev, Elena Novoselova, Viktor Surovtsev, Alexander Guschin

“…Men who have sex with men (MSM) have a high risk of lifelong anal cancer caused by high-risk human papillomavirus (HR HPV) infections. …”
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In vivo MRS study of long-term effects of traumatic intracranial injection of a culture medium in mice by O. B. Shevelev, O. P. Cherkasova, I. A. Razumov, E. L. Zavjalov

“…Consequently, when using animal models of human glioma, researchers should clearly distinguish between which changes in neurometabolites are a response to the injection of cancer cells into the brain, and which processes may indicate the early development of a brain tumor. …”
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Seasonal Changes in the Elemental Composition of Five Valuable Fish Species (<i>Sparidae</i>) from Bozcaada, North Aegean Sea: A Health Risk and Nutritional Benefit Assessment by İlknur Yuvka, Ali Rıza Kosker, Mustafa Durmus, Yılmaz Ucar, Yesim Ozogul

“…Health risk assessments, including Estimated Weekly Intake (EWI), Target Hazard Quotient (THQ), and Cancer Risk (CR), were calculated for both adult and child consumers. …”
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Optimization of In Vivo Studies by Combining Planar Dynamic and Tomographic Imaging: Workflow Evaluation on a Superparamagnetic Nanoparticles System by Maritina Rouchota, Alessio Adamiano, Michele Iafisco, Eirini Fragogeorgi, Irineos Pilatis, Gilles Doumont, Sébastien Boutry, Daniele Catalucci, Argyro Zacharioudaki, George C. Kagadis

“…Molecular imaging holds great promise in the noninvasive monitoring of several diseases with nanoparticles (NPs) being considered an efficient imaging tool for cancer, central nervous system, and heart- or bone-related diseases and for disorders of the mononuclear phagocytic system (MPS). …”
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Diagnostic accuracy of human papillomavirus testing on self-collected samples among women referred for colposcopy by ChunX Yan, Jiong Ma, Xia Zheng, Jing Shu, XiaoJ Wang, XiaoY Chen, Feng Gao, XiaoQ Li, ShanQ M, LongM Huang, XiaoT Yu, XueJ Chen

“…It may be an alternative option for cervical cancer screening. Additional studies are still required to substantiate this issue.…”
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Factors associated with in-hospital mortality in octogenarians managed by geriatric service in a referral hospital in Colombia by Carlos Mario Cortes Bahamon, Jenny Rodríguez Ángel, Jennifer Katherine Ballesteros Tapias, Diego Andrés Chavarro-Carvajal, Oscar Mauricio Muñoz

“…Factors independently associated with mortality were history of cancer (Odds ratio (OR): 2.31; 95% Confidence interval (CI): 1.34–3.98, p  < 0.003), delirium (OR: 2.48; 95% CI: 1.44–4.28, p  < 0.001), malnutrition (OR: 2.50; 95% CI: 1.46–4.28; p  = 0.001), frailty (OR: 2.25; 95% CI: 1.13–4.45, p  = 0.019), tachypnea on admission (OR: 1.09; 95% CI: 1.03–1.14, p  = 0.002), and creatinine elevation (OR: 2.47; 95% CI: 1.47–4.15, p  = 0.001). …”
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Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis by Junko Yoshida, Robert T. Wicks, Andrea I. Zambrano, Betty M. Tyler, Kashi Javaherian, Rachel Grossman, Yassine J. Daoud, Peter Gehlbach, Henry Brem, Walter J. Stark

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Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy by Run‐Wei Song, Tian‐Ci Jiang, Xue‐Yang Zhang, Cheng‐Long Shen, Qing Lou, Chong‐Xin Shan

“…Mechanistically, the excess reactive oxygen species in TME can trigger the chemically initiated singlet/triplet electron exchange between the hydrophobic CDs‐Ce6 and peroxalate‐derived 1,2‐dioxetanes and thus the excess excited singlet/triplet electron of the CDs‐Ce6 can ensure the long‐persistent near‐infrared CL, type I/II photochemical production of hydroxyl radicals, superoxide radical and singlet oxygen, and type III photochemical damage of maladjusted biomacromolecules, enabling the long‐persistent near‐infrared biological imaging and enhanced cancer therapy. These results shed a new sight into the energy transfer mechanism in chemiluminescence and pave a new sight into the architecture of multifunctional theragnostic nanoplatforms.…”
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Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation by Merian E. Kuipers, Dennis K. Ninaber, Krista C.J. van Doorn-Wink, Annelies M. Slats, Pieter S. Hiemstra

“…Abstract Objective Radiation-induced lung injury (RILI) is a serious side-effect of radiotherapy for lung cancer, in which effects on the normal lung epithelium may play a key role. …”
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Three-Dimensional Reconstruction of Oral Tongue Squamous Cell Carcinoma at Invasion Front by Tomoo Kudo, Yoshihito Shimazu, Hisao Yagishita, Toshiyuki Izumo, Yuuichi Soeno, Kaori Sato, Yuji Taya, Takaaki Aoba

“…Based on a pathodiagnostic survey of whole cancer lesions, a core tissue specimen (3 mm in diameter) was dissected out from the deep invasion front using a paraffin tissue microarray. …”
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Adherence to the ISHLT Protocol for the Referral of Patients with Idiopathic Pulmonary Fibrosis to the Transplantation Center among of Czech Centers for Interstitial Lung Diseases by Martina Sterclova, Martina Doubkova, Lubica Sykorova, Vladimir Bartos, Monika Zurkova, Vladimira Lostakova, Radka Mokosova, Martina Plackova, Ladislav Lacina, Michaela Cimrova, Radka Bittenglova, Pavlina Lisa, Pavla Musilova, Daniel Dolezal, Jana Psikalova, Petra Ovesna, Martina Koziar Vasakova

“…Patients with a history of cancer <5 years from the time of IPF diagnosis, patients with alcohol abuse, and patients with an accumulation of vascular comorbidities were excluded. …”
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Comparison of User-Directed and Automatic Mapping of the Planned Isocenter to Treatment Space for Prostate IGRT by Zijie Xu, Ronald Chen, Andrew Wang, Andrea Kress, Mark Foskey, An Qin, Timothy Cullip, Gregg Tracton, Sha Chang, Joel Tepper, Di Yan, Edward Chaney

“…The purpose of this study was to retrospectively compare a fully automatic approach, including a non-rigid step, against a user-directed rigid method implemented in a clinical IGRT protocol for prostate cancer. Isocenters resulting from automatic and clinical mappings were compared to reference isocenters carefully determined in each tCT. …”
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The Essential Role of Monte Carlo Simulations for Lung Dosimetry in Liver Radioembolization—Part B: ¹⁶⁶Ho Microspheres by Edoardo d’Andrea, Andrea Politano, Bartolomeo Cassano, Nico Lanconelli, Marta Cremonesi, Vincenzo Patera, Massimiliano Pacilio

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Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases by Mohammed Q. Qutaish, Zhuxian Zhou, David Prabhu, Yiqiao Liu, Mallory R. Busso, Donna Izadnegahdar, Madhusudhana Gargesha, Hong Lu, Zheng-Rong Lu, David L. Wilson

“…This mouse-to-cells multiscale and multimodality platform should uniquely enable more informative and accurate studies of metastatic cancer imaging and therapy.…”
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Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma by Ji’an Zou, Wei Han, Yan Hu, Chao Zeng, Jina Li, Weixuan Lei, Jieming Cao, Quanming Fei, Mengqi Shao, Junqi Yi, Zeyu Cheng, Li Wang, Fang Wu, Wenliang Liu

“…Abstract Objective With the wide use of CT scan in clinical practice, more lung cancer was diagnosed in resectable stage. Pathological examination and genetic testing have become a routine procedure for lung adenocarcinoma following radical resection. …”
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