Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connecti... by Paola Cordiali-Fei, Anna Mussi, Giovanna D'Agosto, Elisabetta Trento, Valentina Bordignon, Silvana Trincone, Antonella Vento, Isabella Sperduti, Antonio Cristaudo, Fabrizio Ensoli

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Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment effic... by Nakaba Okamura, Ayano Katagiri, Tomoya Komori, Kei Kawanabe, Hirofumi Koike, Yukiko Sahashi, Rie Kubota

“…To assess treatment efficacy, we used non-inferiority analysis with propensity score matching based on age, sex, body mass index, cancer status, and baseline blood test results. The treatment outcomes were evaluated using predefined clinical indicators. …”
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Green synthesis of Au-Pt bimetallic nanoparticels using Croton caudatus Geisel leaf extract and their biological studies by P.Vijaya Kumar, K.S. Pushpavalli, Baskaran Ganesh Kumar, S.Mary Jelastin Kala, K.S. Prakash

“…It has been found that biological studies exploring in vitro antibacterial, in vitro antifungal, and anti-cancerous activity showed significant implications. …”
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Prevalence and characteristics of HPV vaccine hesitancy among parents of adolescent females across Saudi Arabia by Sahar Othman, Ranya Ghamri, Wala Alhamadah, Anwaar Alsatty, Dhuha Khesfaty, Ohoud Alghamdi, Ragad Arbaein, Alaa M. Baglagel, Jumana Khayyat, Bushra Almalki

“…PurposeVaccination against human papillomavirus (HPV) is pivotal in preventing HPV-related diseases, including cervical cancer. However, vaccine hesitancy and their related factors among parents of adolescent females present a significant obstacle to achieving high vaccination rates. …”
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G-UNETR++: A Gradient-Enhanced Network for Accurate and Robust Liver Segmentation from Computed Tomography Images by Seungyoo Lee, Kyujin Han, Hangyeul Shin, Harin Park, Seunghyon Kim, Jeonghun Kim, Xiaopeng Yang, Jae Do Yang, Hee Chul Yu, Heecheon You

“…Accurate liver segmentation from computed tomography (CT) scans is essential for liver cancer diagnosis and liver surgery planning. Convolutional neural network (CNN)-based models have limited segmentation performance due to their localized receptive fields. …”
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Proceso del cuidado enfermero aplicado al adulto mayor con insuficiencia respiratoria por neumonía by Gladis Villanueva Cadenas, Edith Telma Meza Martel, Yulissa Novalí Collantes Vilchez, María del Pilar Medina Siesquén

“…Caso clínico: Adulto mayor, frágil, en dependencia total con índice de Norton 10 y Dowton 5 puntos, con antecedentes de cáncer pulmonar izquierdo, portador de drenaje toráxico, al examen físico presenta temperatura de 39,8 °C, SapO2: 88 %, FR: 27 ciclos por minuto, FC: 145 latidos por minuto, presencia de ruidos sobreagregados roncantes y crepitantes, uso de músculos accesorios y murmullo vesicular abolido en hemitórax izquierdo, tos superficial con secreciones en gran cantidad verdosas. …”
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National Thalassemia Registry: a 30 year journey of implementing carrier screening in Singapore by Stella Zhang, Guek Peng Tan, Soh Lan Peh, Swee Lim Ang, Sylvia Kam, Weng Khong Lim, Teck Wah Ting, Angeline Lai, Ee Shien Tan, Saumya Shekhar Jamuar, Hai Yang Law, Ivy Ng

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Helicobacter pylori infection diagnostics and choice of eradication treatment: results of inquiry of doctors from different regions of Russian Federation by N. N. Dekhnich, R. S. Kozlov, O. A. Sablin, Ye. A. Prischepova

“…Primary diagnostics of H. pylori infection is carried out at peptic ulcer and chronic gastritis by 85 and 84% of surveyed doctors, at GERD - by 59.4%, at NSAID -related gastropathy - by 32%, at MALT lymphoma by 32%, at stomach cancer - by 30.7% and at autoimmune thrombocytopenia - by 16.8% respectively. …”
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Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal flora by Shasha Cui, Xinqiang Liu, Fengxia Han, Lu Zhang, Jingjing Bu, Sainan Wu, Jiafen Wang

“…Conclusion HP CagA+ strains are capable of causing gut microbiota dysbiosis to develop destruction of intestinal barrier, and it may affect the development of colorectal cancer by increasing colonization of Staphylococcus and Corynebacterium.…”
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HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia by Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori

“…Human Leukocyte Antigen-G (HLA-G) contributes to cancer cell immune escape from host antitumor responses. …”
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Diagnostic Performance of Deep Learning Applications in Hepatocellular Carcinoma Detection Using Computed Tomography Imaging by Enes Şahin, Ozan Can Tatar, Mehmet Eşref Ulutaş, Sertaç Ata Güler, Turgay Şimşek, Nihat Zafer Utkan, Nuh Zafer Cantürk

“…Background/Aims: Hepatocellular carcinoma (HCC) is a prevalent cancer that significantly contributes to mortality globally, primarily due to its late diagnosis. …”
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Impacts of medical and non-medical cannabis on the health of older adults: Findings from a scoping review of the literature. by Dianna Wolfe, Kim Corace, Claire Butler, Danielle Rice, Becky Skidmore, Yashila Patel, Premika Thayaparan, Alan Michaud, Candyce Hamel, Andra Smith, Gary Garber, Amy Porath, David Conn, Melanie Willows, Hanan Abramovici, Kednapa Thavorn, Salmaan Kanji, Brian Hutton

“…Medical cannabis had inconsistent therapeutic effects in specific patient conditions (e.g., end-stage cancer, dementia), with a number of studies suggesting possible benefits while others found no benefit. …”
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Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database by Hanzhang Yuan, Jingsheng Cheng, Jun Xia, Zeng Yang, Lixin Xu

“…Patients and methods Differentially expressed genes (DEGs) of glioma were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. …”
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Polymeric Multivalent Fc Binding Peptides‐Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA‐4 by Zongyu Liu, Hongyu Chu, Weidong Zhao, Chenguang Yang, Tongjun Liu, Na Shen, Zhaohui Tang

“…PD1/CTLA‐4 BsAb significantly inhibits tumors in MC38 colon cancer‐bearing mice more effectively than the combination of aPD1 and aCTLA‐4, with tumor suppression rates of 96.8% and 77.3%, respectively. …”
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CHRONOTYPE AND DAILY FUNCTIONING OF PATIENTS WITH DIFFERENT MOTOR SUBTYPES OF PARKINSON DISEASE by A.D. Shkodina, M. Bardhan, K.A. Tarianyk, M. Yu. Delva

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Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors by Guihong Yang, Yimei Wang, Huimin Zhao, Ziyi Jiang, Shansong Zheng, Mingjing Ge, Meimei Si, Xiaoyan Kang

“…Abstract Iruplinalkib (WX‐0593), a selective oral ALK/ROS1 tyrosine kinase inhibitor, was approved in China as first‐line therapy for ALK‐positive non‐small‐cell lung cancer (NSCLC) and for the treatment of locally advanced or metastatic ALK‐positive NSCLC that has progressed following crizotinib therapy. …”
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Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review by Bohao Jiang, Jiyuan Hu, Benqiao Wang, Xujia Liu, Ling Tong, Yitong Xu, Hao Zhang

“…BackgroundPrimary clear cell adenocarcinoma of the urethra (CCAU) is a kind of extremely rare genitourinary cancer. Despite the similarity in the clinical manifestations of these reported cases, diagnosis and determination of standard therapy remain challenging due to the rarity of findings and similarity with other urethral tumors.Case presentationHerein, we reported two cases of CCAU with the same chief complaint of hematuria: a 71-year-old female and a 66-year-old male. …”
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Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis by Glauciane Resende do Nascimento, Ana Carolina da Silva Santos, Nayara Nascimento Toledo Silva, Nathalia Sernizon Guilmarães, Angélica Alves Lima, Wendel Coura-Vital

“…Abstract Background Human Papillomavirus (HPV) is the most common sexually transmitted lower genital tract infection worldwide and the main etiological factor of cervical cancer (CC). Since 2006, vaccines have been implemented to reduce CC-related morbidity and mortality. …”
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Management of Lobular Neoplasia Diagnosed by Core Biopsy by Chinmay Jani, Margaret Lotz, Sarah Keates, Yasha Gupta, Alexander Walker, Omar Al Omari, Arshi Parvez, Dipesh Patel, Maria Gnata, John Perry, Leila Khorashadi, Lisa Weissmann, Susan E. Pories

“…We reviewed the data of breast biopsies conducted at our hospital over this period and included patients who were diagnosed with classic LN (LCIS and/or ALH) and excluded patients having any other atypical lesions on CNB. All known cancer patients were excluded. Of the 2707 CNBs performed during the study period, we identified 68 women who were diagnosed with ALH or LCIS on CNB. …”
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Oncology Clinicians' Perspectives of a Remote Patient Monitoring Program: Multi-Modal Case Study Approach by Ann Marie Mazzella-Ebstein, Robert Daly, Jennie Huang, Camila Bernal, Clare Wilhelm, Katherine S Panageas, Jessie Holland, Rori Salvaggio, Jill Ackerman, Jennifer Cracchiolo, Gilad Kuperman, Jun Mao, Aaron Begue, Margaret Barton-Burke

“…Overall, understanding the usability of RPM applications and their influence on clinical care workflows is limited from the perspectives of clinician end users at a cancer center in the Northeastern United States. …”
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