Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic RECQL4 pathogenic variants have multiple skeletal anomalies and a significantly increased incidence of osteosarcoma. …”
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Social determinants of the healthcare needs of undocumented migrants living with non-communicable diseases: a scoping review by Claudine Burton-Jeangros, Yves Jackson, Janeth Tenorio-Mucha, Corinne Jeffries-Tolksdorf, Jan-Erik Refle

“…Objectives We aimed to map the social determinants of meeting the healthcare needs of undocumented migrants living with non-communicable diseases (NCDs) throughout their migration journey (from the country of origin to the country(/ies) of transit and destination).Design We conducted a scoping review.Data sources We searched literature in Medline, Embase, Web of Science and Google Scholar.Eligibility criteria We included articles that describe interventions, programmes or policies for undocumented migrants living with cardiovascular diseases, cancer, chronic respiratory disease, or diabetes. …”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…PPARγ ligands show great promise in moderating lung inflammation, as antiproliferative agents in combination to enhance standard chemotherapy in lung cancer and as treatments for pulmonary fibrosis, a progressive fatal disease with no effective therapy. …”
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Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification by Qiufang Gong, Xuejiao Song, Yao Tong, Lixuan Huo, Xuefen Zhao, Yingying Han, Wei Shen, Jiaxi Ru, Xian Shen, Chao Liang

“…Overturning the unique pH gradient of tumor cells has exhibited to be a viable approach for cancer therapy. In this review, the formation and regulatory mechanisms of the acidic microenvironment in solid tumors will be firstly outlined. …”
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On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies by Andreea Calinescu, Gabriela Turcu, Roxana I. Nedelcu, Alice Brinzea, Anastasia Hodorogea, Mihaela Antohe, Carmen Diaconu, Coralia Bleotu, Daniel Pirici, Lucia B. Jilaveanu, Daniela A. Ion, Ioana A. Badarau

“…The importance of understanding the role of CEACAM1 in cell transformation stands not only in this adhesion molecule’s value as a prognostic factor but also in its promising premise as a potential new molecular target that could be exploited as a specific cancer therapy.…”
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Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies by Gamil A. Al-Hazmi, Khlood S. Abou-Melha, Nashwa M. El-Metwaly, Kamel A. Saleh

“…Applying AutoDockTools 4.2 program over all perimidine derivatives introduces efficiency against 4c3p protein of breast cancer. Antitumor activity was screened for all compounds by a comparative view over breast, colon, and liver carcinoma cell lines. …”
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Beta-Blockers for Primary Prevention of Anthracycline-Induced Cardiac Toxicity: An Updated Meta-Analysis of Randomized Clinical Trials by Armin Attar, Arman Karimi Behnagh, Mehrasa Hosseini, Foad Amanollahi, Paria Shafiekhani, Ali Kabir

“…The secondary outcome was the development of Cancer Therapeutics–Related Cardiac Dysfunction (CTRCD), defined as a decrease in the LVEF of >10% to a value of <53%. …”
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Morphological Evidence for a Subpopulation Selection Effect by Estrogen and Antiestrogen Treatments in the Heterogeneous MCF-7 Cell Line by Jacqueline Palmari, France Wallet, Julien Berard, Yolande Berthois, Pierre Marie Martin, Christophe Dussert

“…The method, previously used to analyse the proliferation of the breast cancer cell line MCF‐7, was applied here to analyse the growth of this cell line under estradiol (E2), hydroxytamoxifen (OH‐TAM), and both E2 and OH‐TAM treatments. …”
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Serum assisted PD-L1 aptamer screening for improving its stability by Yu Zhou, Haozhe Zhang, Yujing Ding, Changyuan Yu, Hao Li

“…With its improved stability, higher affinity and specificity, Apt-S1 holds great potential for applications in PD-L1 assisted cancer diagnosis and treatment. Meanwhile, the results obtained in this work provide further evidence of the advantages of the real capture-SELEX strategy in improving aptamer stability compared to the traditional strategy.…”
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The Prognostic Significance of TRs in Hepatocellular Carcinoma: Insights from TCGA and GEO Databases by Hao Zhou, Weijie Wang, Ruopeng Liang, Rongtao Zhu, Jiahui Cao, Chenguang Sun, Yuling Sun

“…Methods: This study utilized Kaplan-Meier analysis of TR expression profiles from The Cancer Genome Atlas (TCGA). Expression levels of TRs in HCC and immune single cells were assessed using datasets from the Gene Expression Omnibus (GEO) and TCGA, analyzed with R software. …”
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Stent Selection for Endoscopic Ultrasound-Guided Drainage of Pancreatic Fluid Collections: A Multicenter Study in China by Hui Lin, Xian-Bao Zhan, Si-Yu Sun, Xiu-Jiang Yang, Zhen-Dong Jin, Duo-Wu Zou, Zhao-Shen Li

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Development of a 3-MicroRNA Signature and Nomogram for Predicting the Survival of Patients with Uveal Melanoma Based on TCGA and GEO Databases by Jun Zuo, Hongquan Ye, Jing Tang, Jianqun Lu, Qi Wan

“…Methods. miRNA and mRNA sequencing data for 80 UM patients were obtained from The Cancer Genome Atlas (TCGA) database. The patients were further randomly assigned to a training set (n = 40, used to identify key miRNAs) and a testing set (n = 40, used to internally verify the signature). …”
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Disease prediction by network information gain on a single sample basis by Jinling Yan, Peiluan Li, Ying Li, Rong Gao, Cheng Bi, Luonan Chen

“…., an influenza dataset and three cancer datasets.…”
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A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data by Xiaoqiong Li, Kejiang Wang, Jiaxin Liu, Yan Li

“…Abstract Background Thyroid carcinoma (THCA) is the most common cancer of the endocrine system. Natural killer (NK) cell play an important role in tumor immune surveillance. …”
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Biomedical named entity recognition using improved green anaconda-assisted Bi-GRU-based hierarchical ResNet model by Ram Chandra Bhushan, Rakesh Kumar Donthi, Yojitha Chilukuri, Ulligaddala Srinivasarao, Polisetty Swetha

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Endometrial polyps with bizarre stromal cells: a Benign or a low-grade lesion? by Musen Wang, Fei Gao, Hongkai Zhang, Wenxin Zheng

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Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione by Nebojša Đ. Pantelić, Bojana B. Zmejkovski, Željko Žižak, Nebojša R. Banjac, Bojan Đ. Božić, Tatjana P. Stanojković, Goran N. Kaluđerović

“…In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. …”
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Homologous In-Radiolabeled Platelet Survival and Sequestration Exploration for Refractory Immunologic Thrombocytopenic purpura in Children: A Strategy to Avoid Unnecessary Splenect... by Julien Dubois PharmD, Florentin Kucharczak PhD, Léa De Neef PharmD, Virginie Kouyoumdjian PharmD, Gilles Palenzuela MD, Virginie Tunez MD, Denis Mariano-Goulart MD, PhD, Aurélie Bourdon MD, Tom Paunet MD

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Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads? by Periyasamy Sivalingam, Kui Hong, John Pote, Kandasamy Prabakar

“…Consequently, the increased morbidity and mortality, which are associated with multidrug resistance bacteria, urgently require the discovery of novel and more efficient drugs. Conversely, cancer is a growing complex human disease that demands new drugs with no or fewer side effects. …”
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The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression by Tian Yi Kang, Hua Rong Yang, Jie Zhang, Dan Li, Jie Lin, Li Wang, XiaoPing Xu

“…Persistently increasing incident of cancer in human beings has served to emphasize the importance of studies on mechanism of antitumor substances. …”
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