Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Abstract To better understand drug resistance mechanisms to CDK4/6 inhibitors and inform precision medicine, we analyze real-world multi-omics data from 400 HR+/HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapies, including 200 pre-treatment and 227 post-progression samples. …”
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Assessment of Radionuclide Concentration in Surface Soil and Human Health Risk Associated with Exposure in Two Higher Institutions of Esan land, Edo State, Nigeria by F.A. Popoola, O.D. Fakeye, Q.B. Basiru, D.A. Adesina, M.A. Sulola

“…The total mean values for radiation dose estimation for Radium Equivalent Activity, Absorbed Dose, Excess Lifetime Cancer Risk, Outdoor and Indoor Annual Effective Dose Equivalent are 13.20 BqKg-1, 6.03 nGy/ℎ, 0.026, 7.40 µSτ/γ and 29.60 µSτ/γ respectively. …”
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Evaluating the occurrence of trihalomethanes in drinking water and their implications for human health risk by Victor Constantin Cojocaru, Valentina Andreea Petre, Ana Ioana Paris, Nicolae Ionut Cristea, Florentina Laura Chiriac, Ioana-Antonia Cimpean

“…Carcinogenic risk assessments indicate a similar trend, with total risks for women varying between 1.37×10-6 and 1.88×10-4, and for men between 2.22×10-7 and 1.66×10-4. comparable values for cancer risk that exceed the minimum or negligible risk threshold established by the USEPA (1.00×10-6).…”
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Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-H... by Amani S. Alturiqi, Abdel-Nasser M. A. Alaghaz, Reda A. Ammar, Mohamed E. Zayed

“…The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.…”
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Antioxidant and Antimicrobial Properties of the Essential Oil and Extracts of Zanthoxylum alatum Grown in North-Western Himalaya by Sanjay Guleria, A. K. Tiku, Apurva Koul, Sahil Gupta, Gurjinder Singh, V. K. Razdan

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Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate by Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar, Olexandr V. Ogloblya, Volodymyr K. Rybalchenko

“…In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative colitis (UC) model was aimed to be discovered. …”
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Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258 by Prashantkumar Siddappa Chakra, Aishwarya Banakar, Shriram Narayan Puranik, Vishwas Kaveeshwar, C. R. Ravikumar, Devaraja Gayathri

“…Additionally, the NPs were photocatalytically and electrochemically analyzed, indicating their potential use in cancer research as well as in coating and drug delivery applications.…”
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Leukemia Stem Cell-Released Microvesicles Promote the Survival and Migration of Myeloid Leukemia Cells and These Effects Can Be Inhibited by MicroRNA34a Overexpression by Yue Wang, Qian Cheng, Jing Liu, Min Dong

“…Recent evidence indicates that microvesicles (MVs) released from cancer stem cells can promote tumor growth and invasion. …”
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The impact of the COVID-19 pandemic on mental coping and emergency ability of public health emergency in COVID-19 department healthcare workers in ICU nurses of Beijing in China by Tiantian Gai, Yin He, Ying Yin, Yu Cui, Qiuping Li, Yanzhen Hu, Zhenhui Lu

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Clinical Effect of Preservation or Nonpreservation of Left Colic Artery in Total Mesorectal Excision under Laparoscopy: A Meta-analysis by Jiefeng Liu, Yujing Gong, Miao He, Xinyu Zeng, Yiping Liu

“…The words, like “rectal cancer,” “left colonic artery,” and “laparoscopy,” were used as the retrieval terms, and the keyword retrieval method was adopted. …”
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Photodynamic Therapy (PDT) in drug delivery: Nano-innovations enhancing treatment outcomes by Ahmed N. Al-Jamal, Ali Fawzi Al-Hussainy, Bahira Abdulrazzaq Mohammed, Hadi Hussein Abbas, Issa Mohammed Kadhim, Zahraa Hassan Ward, Debarshi Kar Mahapatra, Tomy Muringayil Joseph, Ehsan kianfar, Sabu Thomas

“…One approach to treating cancer and other infections is Photodynamic Therapy (PDT). …”
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In situ-formed cryomicroneedles for intradermal cell delivery by Mengjia Zheng, Tianli Hu, Yating Yang, Xuan Qie, Huaxin Yang, Yuyue Zhang, Qizheng Zhang, Ken-Tye Yong, Wei Liu, Chenjie Xu

“…As a proof-of-concept, we examined the loading and intradermal delivery of three cell types in clinically relevant in vitro and in vivo models, including mesenchymal stem cells for wound healing, melanocytes for vitiligo treatment, and antigen-pulsed dendritic cells for cancer vaccination.…”
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Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians by Larisa Geskin, Christiane Querfeld, Emmilia Hodak, Neda Nikbakht, Evangelia Papadavid, Marco Ardigò, Ulrike Wehkamp, Martine Bagot

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Bayesian Analysis of Complex Mutations in HBV, HCV, and HIV Studies by Bing Liu, Shishi Feng, Xuan Guo, Jing Zhang

“…We envisage the applications of more modified Bayesian methods to other infectious diseases and cancer cells that will be following with critical medical results before long.…”
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Exploration and Verification of Prognostic Value of Endothelial Cells in Glioblastoma by Hengchao MA, Yuyang LIU, Jun XU, Bingyan TAO, Jun ZHANG

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Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response by Noha Sayed Hamed, Eithar K. El Adham, Amal I. Hassan

“…Background: Numerous forms of cancer are frequently treated with radiation therapy, which provides substantial benefits in tumor control. …”
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Efficient Implementation of Mahalanobis Distance on Ferroelectric FinFET Crossbar for Outlier Detection by Musaib Rafiq, Yogesh Singh Chauhan, Shubham Sahay

“…The proposed implementation utilizes two crossbar arrays of ferroelectric FinFETs to calculate the Mahalanobis distance and detect outliers in the popular Wisconsin breast cancer dataset using a novel inverter-based threshold circuit. …”
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Evaluation of the Relationship Between Histopathological Tissue Diagnosis and Endometrial Thickness in Cases with Postmenopausal Bleeding by Mehmet Şükrü Budak, Mehmet Baki Şentürk, Sedat Akgöl, Mehmet Obut, Ali Emre Tahaoğlu, Cihan Toğrul, Ayhan Yıldırım

“…It appears that high parity ratios reduce the endometrium cancer risk. …”
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An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib by Zhenzhen Ying, Jingyao Wei, Ruijuan Liu, Fang Zhao, Yifang Yu, Xin Tian

“…Osimertinib is a novel oral, potent, and irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for treatment of advanced T790M mutation-positive advanced non-small cell lung cancer, which is commonly combined with ginsenoside Rg3 in clinic to enhance the efficacy and minimize adverse reactions. …”
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Influence of Process Parameters on Content Uniformity of a Low Dose Active Pharmaceutical Ingredient in a Tablet Formulation According to GMP by Muselík Jan, Franc Aleš, Doležel Petr, Goněc Roman, Krondlová Anna, Lukášová Ivana

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