Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma by Jie Chen, Chengyu Feng, Yufei Lan, Xiangtian Chen, Zhengqi Peng, Zihan Huang, Ruiqing Wang, Wenxin Zhang, Yingying Ye, Zhilei Mao, Dongyue Pan, Lihua Yang

Get full text

The Role of Pharmaceutical Innovation in Clinical Practice Guidelines for Chronic Diseases by Meaghan Roach, Natalie Land, Jennifer Hernandez, Reina Rau, Jacquelyn W. Chou, Stacey S. Hickson, Danielle F. Rollmann, J. Ross Maclean

“…Clinical practice guidelines published from 2000 to 2021 were identified for five chronic diseases: ischemic heart disease (IHD), non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), Alzheimer’s disease (AD), and type 2 diabetes (T2D). …”
Get full text

HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design by Amy L. Kessler, Roel F. A. Pieterman, Wouter A. S. Doff, Karel Bezstarosti, Rachid Bouzid, Kim Klarenaar, Diahann T. S. L. Jansen, Robbie J. Luijten, Jeroen A. A. Demmers, Sonja I. Buschow

“…Abstract Synthetic long peptides (SLPs) are a promising vaccine modality that exploit dendritic cells (DC) to treat chronic infections or cancer. Currently, the design of SLPs relies on in silico prediction and multifactorial T cells assays to determine which SLPs are best cross-presented on DC human leukocyte antigen class I (HLA-I). …”
Get full text

Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure by E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov

“…TCDD is the most toxic among the dioxin xenobiotics and induces a broad spectrum of biological responses, including immunotoxicity and cancer. The complex ligand:AhR:ARNT functions as a transcription factor, binding to the dioxin responsive element (DRE) sequences in the regulatory regions of target genes. …”
Get full text

Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Marius B. Tincho, Thureyah Morris, Mervin Meyer, Ashley Pretorius

“…Antimicrobial Peptides (AMPs) are components of the first line of defense for prokaryotes and eukaryotes and have a wide range of activities against Gram-negative and Gram-positive bacteria, fungi, cancer cells, and protozoa, as well as viruses. In this study, peptides which were initially identified for their HIV inhibitory activity were further screened for antibacterial activity through determination of their kinetics as well as their cytotoxicity. …”
Get full text

Role of the Kaiso gene in the development of inflammation in Mucin-2 defcient mice by E. A. Litvinova, K. M. Achasova, M. A. Borisova, S. V. Zhenilo, E. B. Prokhortchouk, E. N. Kozhevnikova

“…Some of transcription factors that change the expression of intestinal genes are involved in the development of IBD and colorectal cancer. One of such transcription factors is “zinc fnger” domain-containing protein Kaiso which is able to bind to methylated DNA. …”
Get full text

Loss of H2A.Z Is Not Sufficient to Determine Transcriptional Activity of Snf2-Related CBP Activator Protein or p400 Complexes by Tamara A. Bowman, Madeline M. Wong, Linda K. Cox, Joseph J. Baldassare, John C. Chrivia

Get full text

Genetic Variants Associated with Chronic Obstructive Pulmonary Disease Risk: Cumulative Epidemiological Evidence from Meta-Analyses and Genome-Wide Association Studies by Caiyang Liu, Ran Ran, Xiaoliang Li, Gaohua Liu, Xiaoyang Xie, Ji Li

Get full text

Tacrolimus and mycophenolate mofetil in corticosteroid-resistant hepatitis secondary to tislelizumab: a case report by Chang Jiang, Shanxian Guo

“…In patients with extensive-stage small-cell lung cancer (ES-SCLC), the first-line use of tislelizumab combined with chemotherapy has shown significant efficacy. …”
Get full text

Interventions to promote the implementation of pressure injuries prevention measures in nursing homes: a scoping review protocol by Yu Liu, Chun-Tao Wu, Long-Fei Yang, Yan-Ling Liu, Cui-Ping Ni

Get full text

Chitinase 3‐like 1 is neurotoxic in multiple sclerosis patient‐derived cortical neurons by Rucsanda Pinteac, Jordi Soriano, Clara Matute‐Blanch, José M Lizcano, Anna Duarri, Sunny Malhotra, Herena Eixarch, Gloria López Comellas, Xavier Montalban, Manuel Comabella

Get full text

Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p by Qian Zhang, Shan Chen, Yingwei Zhen, Peng Gao, Zhenyu Zhang, Hao Guo, Yong Wang

“…Recently, increased studies have shown the important regulatory role of circular RNA (circRNA) in cancer progression and development, including glioblastoma (GBM). …”
Get full text

Impact of ABO gene polymorphism and von Willebrand factor on genetic susceptibility to acute lymphoblastic leukemia in Egyptian pediatric patients by Elsayed I. Salim, Ahmed N. Shaaban, Amal K. Seleem, Zeinab I. Attia

“…The ABO blood group system and von Willebrand factor (VWF) have been associated with altering cancer risk, but few studies have examined their relationship with pediatric ALL. …”
Get full text

Mortalidad por tumores malignos en la provincia Cienfuegos en los años 2004-2013 by Noemí Domitila Bergantiño Collazo, Ada Elva Suárez Rodríguez

“…<strong>Fundamento:</strong> el cáncer es en la actualidad, una de las principales causas de muerte en todo el mundo, se calcula que 84 millones de personas morirán por esta causa antes del 2015. …”
Get full text

Real-Time Physics Simulation Method for XR Application by Nak-Jun Sung, Jun Ma, Kunthroza Hor, Taeheon Kim, Hongly Va, Yoo-Joo Choi, Min Hong

Get full text

A IMPLEMENTAÇÃO DA TELENFERMAGEM NO PERÍODO PÓS-OPERATÓRIO MEDIATO E TARDIO by Ana Paula Silvestre dos Santos Azevedo, Lilian Burguez Romero, Rosilene Alves Ferreira, Andressa Aline Bernardo Bueno, Diana Amado Baptista dos Santos, Raphael Duarte Chança, Cintia Silva Fassarella

Get full text

Nano-Azo Ligand and Its Superhydrophobic Complexes: Synthesis, Characterization, DFT, Contact Angle, Molecular Docking, and Antimicrobial Studies by Gehad G. Mohamed, Walaa H. Mahmoud, Ahmed M. Refaat

“…The binding between H2L and its Cd(II) complex with receptors of the crystal structure of S. aureus (PDB ID: 3Q8U), crystal structure of protein phosphatase (PPZ1) of Candida albicans (PDB ID: 5JPE), receptors of breast cancer mutant oxidoreductase (PDB ID: 3HB5), and crystal structure of Escherichia coli (PDB ID: 3T88) was predicted and given in detail using molecular docking.…”
Get full text

Severe anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis with prolonged hyperammonemia: a case report by Chunxia Yan, Lingling Bai, Jingwei Du, Zonglei Chong, Guangjun Xu, Xiaoqian Yang

“…However, 10 months after discharge, he was readmitted to the hospital due to seizures and subsequently diagnosed with lung cancer. The patient eventually passed away at home. …”
Get full text

Improved Binary Grey Wolf Optimization Approaches for Feature Selection Optimization by Jomana Yousef Khaseeb, Arabi Keshk, Anas Youssef

“…The three proposed approaches were evaluated using nine small-instance, high-dimensional, cancer-related human gene expression datasets. A set of comparisons were made against the original binary versions of both GWO and PSO algorithms and against eight state-of-the-art feature selection binary optimizers in addition to one of the recent binary optimizers that combines PSO with GWO. …”
Get full text

Herbaspirillum Infection in Humans: A Case Report and Review of Literature by Rashmi Dhital, Anish Paudel, Nidrit Bohra, Ann K. Shin

“…We present a 58-year-old female with non-small-cell lung cancer (NSCLC) who presented with pneumonia and was found to have Herbaspirillum seropedicae bacteremia. …”
Get full text