Synthesis, DNA-Binding, Anticancer Evaluation, and Molecular Docking Studies of Bishomoleptic and Trisheteroleptic Ru-Diimine Complexes Bearing 2-(2-Pyridyl)-quinoxaline by Sofia Balou, Athanasios Zarkadoulas, Maria Koukouvitaki, Luciano Marchiò, Eleni K. Efthimiadou, Christiana A. Mitsopoulou

“…MTT experiments revealed that both complexes induce apoptosis of MCF-7 (breast cancer) cells in low concentrations. Confocal microscopy indicated that 2 localizes in the nucleus and internalizes more efficiently in MCF-7 than in HEK-293.…”
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Burden of HPV-induced diseases and cost effectiveness of catch-up vaccination in Czech Republic: a model-based study by Vojtech Kamenský, Lukáš Dostálek, Martin Rožánek, Aleš Tichopád, Roman Prymula, Ivana Šarkanová

“…Abstract Objectives Human papillomavirus (HPV) infections are highly prevalent sexually transmitted infections, notably associated with various cancers. This study analyses the health and economic impacts of HPV-associated diseases in the Czech Republic and evaluates the cost-effectiveness of a catch-up vaccination program. …”
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A critical review on the health promoting effects of mushrooms nutraceuticals by Gaoxing Ma, Wenjian Yang, Liyan Zhao, Fei Pei, Donglu Fang, Qiuhui Hu

“…Due to its high quality of proteins, polysaccharides, unsaturated fatty acids, mineral substances, triterpenes sterols and secondary metabolites, mushrooms have always been appreciated for their vital role in protecting and curing various health problems, such as immunodeficiency, cancer, inflammation, hypertension, hyperlipidemia, hypercholesterolemia and obesity. …”
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Assessing the health and economic burden of obesity-related complications in East-Asian populations: implementation of risk equations in the Core Obesity Model for Japan and model... by Ichiro Tatsuno, Mark Lamotte, Laetitia Gerlier, Anamaria-Vera Olivieri, James Baker-Knight

“…Internal and external validation were performed.Results Overall, good internal validity was achieved, with mild underestimation for diabetes, cardiovascular and all-cause death taken together (ordinary least squares linear regression [OLS-LRL] 0.8844), moderate overestimation of TKR and cancers (OLS-LRL 1.267) and a slight underestimation for NAFLD and hyperuricaemia (OLS-LRL 0.934). …”
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Meta-Analysis of Integrated Therapeutic Methods in Noninvasive Lower Back Pain Therapy (LBP): The Role of Interdisciplinary Functional Diagnostics by Aleksandra Bitenc-Jasiejko, Krzysztof Konior, Danuta Lietz-Kijak

“…Quite often, it is a consequence of many years of disturbed distribution of tension within the human body caused by local conditions (injuries, hernias, stenoses, spondylolisthesis, cancer, etc.), global factors (postural defects, structural integration disorders, lifestyle, type of activity, etc.), or systemic diseases (connective tissue, inflammation, tumours, abdominal aneurysm, and kidney diseases, including urolithiasis, endometriosis, and prostatitis). …”
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Clinicopathological Findings of Retinoblastoma: A 10-Year Experience from a Tertiary Hospital in Kampala, Uganda by James Joseph Yahaya, Belson Rugwizangoga, Alex Mremi, Asafu Munema

“…Retinoblastoma (RB) is one of the most common cancers occurring in young children in sub-Saharan Africa. …”
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Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Abstract Vincristine (VCR) is one of the most widely used chemotherapy agents in treating pediatric cancer. Nonetheless, it is known to cause dose-dependent neurotoxicity which can impact virtually every organ system. …”
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Trends in incidence, prevalence, and mortality of non-communicable diseases in Iraq (2003–2021) by Mohammed Merzah

“…However, older males still face high death rates from cardiovascular diseases. Rising cases of cancer, diabetes, and kidney diseases signal the need for targeted interventions. …”
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Relaxin inhibits 177Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway by Xu Junhua, Wan Song, Chen Wei, Zhang Yi, Ji Zhenzhong

“…177Lu-EDTMP (Ethylenediamine tetramethylene phosphonic acid) is the most used radioactive agent for pain palliation in bone cancer patients. The present study aims to study the impact of relaxin-2 on the 177Lu-EDTMP associated cell toxicity and death in osteosarcoma cells. …”
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Depressive symptomatology in Brazil: perspectives of statistical and psychometrics analyses of the PHQ-9 at four time-points (2020–2023) in the COVID-19 pandemic by Andre Faro, Daiane Nunes, Derek Falk

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Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action by Humberto Nicastro, Claudia Ribeiro da Luz, Daniela Fojo Seixas Chaves, Luiz Roberto Grassmann Bechara, Vanessa Azevedo Voltarelli, Marcelo Macedo Rogero, Antonio Herbert Lancha

“…The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. …”
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Representing unsegmented vessels using available vascular data for bioheat transfer simulation by Rohan Amare, Amir A. Bahadori, Amir A. Bahadori, Steven Eckels, Steven Eckels

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Associations between an gene polymorphism and ulcerative colitis by ARMS-PCR by Mahsa Sadat Hashemi Doulabi, Reza Goleyjani Moghaddam, Ali Salehzadeh

“…This finding is of note because the occurrence of intestinal inflammation and subsequent ulcers can precede the development of cancer.…”
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Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma by Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi

“…Renal cell carcinoma (RCC) accounts for the majority of cancer-related deaths worldwide. Overexpression of CD70 has been linked to advanced stages of RCC. …”
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Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion by Yang Xia, Chunye Huang, Min Zhong, Hongguang Zhong, Ruiwen Ruan, Jianping Xiong, Yangyang Yao, Jing Zhou, Jun Deng

“…In this review, we examine the impact of abnormal activation of the HGF/c-MET signaling pathway on the control of the TME and the processes governing PD-L1 expression in cancer cells. The review thoroughly examines both clinical and practical evidence regarding the use of c-MET inhibitors alongside PD-1/PD-L1 inhibitors, emphasizing that focusing on c-MET with immunotherapy enhances the effectiveness of treating MET tumors exhibiting elevated PD-L1 expression.…”
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Removing limitations surrounding terpenoid biosynthesis by biotechnological techniques in Ferula sp.: A review by Zahra Aghaali, Jun-Li Yang, Mohammad Reza Naghavi, Meisam Zargar

“…Since ancient times, Ferula species has been utilized to treat various health issues, such as asthma, toothache, inflammation, cancer, and digestive disorders. Besides, a growing body of research proves the healing efficacy of Ferula plants in treating modern diseases, such as multiple sclerosis (MS), HIV, and COVID19. …”
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Carcinoma hepatocelular gigante en hígado cirrótico. Presentación de un caso y revisión de la literatura by Jorge Luis Montes de Oca Mastrapa, Johnny Pérez Betancourt, Alejandro Cisneros Carmenate

“…Constituye el sexto tumor más habitual en el mundo, entre 500.000 y un millón de casos diagnosticados cada año y es la segunda causa más común de muerte por cáncer. La enfermedad se desarrolla de manera casi exclusiva en pacientes con una enfermedad hepática crónica subyacente, del 85 al 95 %, que han desarrollado cirrosis. …”
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Efficacy and Safety of Endoscopic Submucosal Dissection for Dysplasia in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis by Qi-Shan Zeng, Zhi-Jing Zhao, Jiao Nie, Min Zou, Jia-Hui Yang, Jin-Zhi Zhang, Hua-Tian Gan

“…Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer. Current guidelines recommend endoscopic resection if the lesion is visible with distinct margins and a complete resection can be achieved. …”
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HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China by Fangli Cao, Hui Han, Fang Zhang, Baozhong Wang, Wei Ma, Yanwen Wang, Guiming Sun, Miao Shi, Yubo Ren, Yufeng Cheng

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Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology by Jessica Ramirez, Pincas Bitterman, Sanjib Basu, Animesh Barua

“…In addition, we examined changes in nuclear expression of IL-16 expression with regards to exposure to follicle-stimulating hormone (FSH) by in vitro cell culture assays with human ovarian cancer cells. The frequencies of IL-16 expressing cells were significantly higher in ovarian stroma in women at early and late menopause as compared with premenopausal women (P<0.0001). …”
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