Design and implementation of an asynchronous online course-based undergraduate research experience (CURE) in computational genomics. by Seema B Plaisier, Danielle O Alarid, Joelle A Denning, Sara E Brownell, Kenneth H Buetow, Katelyn M Cooper, Melissa A Wilson

“…We generated custom learning materials and leveraged remotely accessible computational tools to address 2 novel research questions over 2 iterations of the genomics CURE, one testing bioinformatics approaches and one mining cancer genomics data. Here, we present how the instructional team distributed analysis needed to address these questions between students over a 7.5-week CURE and provided concurrent training in biology and statistics, computer programming, and professional development. …”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Combination therapy using antibodies and natural killer (NK) effectors, which are innate immune cells with safe and potent antitumor activity, is a promising approach for cancer immunotherapy and can enhance antitumor effects. …”
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The Mast Cell Is an Early Activator of Lipopolysaccharide-Induced Neuroinflammation and Blood-Brain Barrier Dysfunction in the Hippocampus by Yiwei Wang, Huanhuan Sha, Leting Zhou, Yinan Chen, Qin Zhou, Hongquan Dong, Yanning Qian

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Efficacy and safety of high-voltage versus standard-voltage pulsed radiofrequency ablation for patients with neuropathic pain: protocol for a systematic review and meta-analysis by Zheng Wang, Yitong Jia, Yanhui Ma, Tengteng Wang, Kunpeng Feng, Guang Feng, Tianlong Wang

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Investigation of groundwater quality indices and health risk assessment of water resources of Jiroft city, Iran, by machine learning algorithms by Sobhan Maleky, Maryam Faraji, Majid Hashemi, Akbar Esfandyari

“…The non-carcinogenic risk assessment revealed that children had the highest hazard quotient for oral and dermal intake, with values ranging from 0.47 to 13.53 for oral intake and 0.001 to 0.05 for dermal intake. The excess lifetime cancer risk of arsenic for children, adult females, and males was found to be from 2.5 × 10–4 to 7.2 × 10–3, 1.2 × 10–4 to 3.6 × 10–3, and 4.3 × 10–5 to 1.2 × 10–3, respectively. …”
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Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications by Hai Jiang, Ranil Vikraman Kumarasamy, JinJin Pei, Kamaraj Raju, Gopalakrishnan Velliyur Kanniappan, Chella Perumal Palanisamy, Ion Dan Mironescu

“…Highlighting various applications, including targeted drug delivery, cancer therapy, and vaccine development, the review underscores the potential of EV-nanomaterial hybrids to leverage EVs’ innate targeting capabilities and the versatility of nanomaterials. …”
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Cross-referencing French hematology teams’ knowledge and perception of end-of-life situations: a national mixed-methods survey by Chloé Prod’homme, Côme Bommier, Laurène Fenwarth, Stephane Moreau, Alice Polomeni

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Switched CMOS current source compared to enhanced Howland circuit for bio-impedance applications by da Silva Pablo Dutra, Filho Pedro Bertemes

“…Bio-impedance Spectroscopy (BIS) is a technique that allows tissue analysis to diagnose a variety of diseases, such as medical imaging, cancer diagnosis, muscle fatigue detection, glucose measurement, and others under research. …”
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Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea by Katsuo Tomoyose, Yuka Okada, Takayoshi Sumioka, Masayasu Miyajima, Kathleen C. Flanders, Kumi Shirai, Tomoya Morii, Peter S. Reinach, Osamu Yamanaka, Shizuya Saika

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Primary Nocardia Infection Causing a Fluorodeoxyglucose-Avid Right Renal Mass in a Redo Lung Transplant Recipient by Sreeja Biswas Roy, Mitchell D. Ross, Pradnya D. Patil, Richard Trepeta, Ross M. Bremner, Tanmay S. Panchabhai

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Spore-Derived Isolates from a Single Basidiocarp of Bioluminescent <i>Omphalotus olivascens</i> Reveal Multifaceted Phenotypic and Physiological Variations by Rudy Diaz, David Bermudes

“…This same subset produced an anticancer agent that was highly potent against MDA-MB-468 breast cancer tumor cells. We interpret these variations in haploids as significant in altering <i>Omphalotus</i> physiology and its production of secondary metabolites, which may in turn alter their ecology and life cycle, and could be further applied to studying fungal physiologies and facilitate linking them to their genetic underpinnings.…”
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A fulminant case of JC virus encephalopathy supporting a novel syndrome associated with JC virus infection of cortical neurons by Matteo Ciocca, Marta Pirovano, Monica Lodi, Antonino Romeo, Vincenza Fetoni

“…A whole-body CT scan was negative for cancer. Several EEGs showed a diffuse anterior theta activity with bilateral parietal epileptic periodic discharges. …”
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TERT-TP53 mutations: a novel biomarker pair for hepatocellular carcinoma recurrence and prognosis by Jin Li, Ling Bai, Zhaodan Xin, Jiajia Song, Hao Chen, Xingbo Song, Juan Zhou

“…Abstract Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, and ranks among the most lethal malignancies globally, primarily due to its high rates of recurrence and metastasis. …”
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Rhabdomyolysis-Induced Acute Kidney Injury in Diabetic Emergency: Underdiagnosed and an Important Association to Be Aware of by Ami Amin, Bhavika Gandhi, Steven Torre, Alireza Amirpour, Jennifer Cheng, Mayurkumar Patel, Mohammad A. Hossain

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Glycosylation of ceramide synthase 6 is required for its activity by Alexandra J. Straus, Grace Mavodza, Can E. Senkal

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Airborne Ultrafine Particle and Acute Physiological Effects during Maximal Aerobic Power Test by Angelo Rodio, Francesco Misiti, Alessandro Zagaglia, Luca Stabile, Giorgio Buonanno, Luigi Fattorini

“…Abstract Background The practice of physical exercise in polluted areas could lead to adverse health effects that may contribute to the incidence and/or worsening of respiratory and cardiovascular diseases and some types of cancer. Methods Male recreational cyclists performed tests in a manner randomized crossover in two environmental conditions: low (environmental noise exposure) and high ultrafine particle concentration. …”
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Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision by Chenglong Fan, Guanglin Yang, Cheng Li, Jiwen Cheng, Shaohua Chen, Hua Mi

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Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas by Arjen H. G. Cleven, Manon van Engeland, Bradly G. Wouters, Adriaan P. de Bruïne

“…Conclusion: These observations show, that expression of hypoxia regulated proteins in tumor-associated stromal cells, as opposed to their expression in epithelial tumor cells, is associated with poor outcome in colorectal cancer. This study suggests that tumor hypoxia may influence tumor-associated stromal cells in a way that ultimately contributes to patient prognosis.…”
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GC-MS Profiling and Therapeutic Potentials of Prosopis juliflora (Sw.) DC: Cytotoxic and Antimicrobial Insights by Asaad Khalid, Eltuhami A. Abdalgadir, Iman K. Abdel Gadir, Ashraf N. Abdalla, Husham E. Homeida, Shahnaz Sultana, Zia ur Rehman, Rym Hassani, Ahmed Shaher Alqahtani, Hassan A. Alhazmi

“…Cytotoxic activity was seen in human breast cancer (MCF-7), human ovary adenocarcinoma (A2780), and human colon adenocarcinoma (HT-29) cell lines, as well as in normal human fetal lung fibroblasts (MRC-5), when subjected to the MTT assay. …”
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Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab by Taylor Pindi Sala, Jean-Marie Michot, Renaud Snanoudj, Marion Dollat, Emmanuel Estève, Bernadette Marie, Yacine Taoufik, Jean-François Delfraissy, Thierry Lazure, Olivier Lambotte

“…Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with medical history of kidney transplantation for segmental glomerular hyalinosis. …”
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