The Active Compound Thymoquinone Alters Chondrogenic Differentiation of Human Mesenchymal Stem Cells via Modulation of Intracellular Signaling by Banu ISKENDER

“…Previous evidence suggested that thymoquinone (TQ) suppresses tumor necrosis factor-α-mediated NF-κB activation in different cancer cell lines. The suppression of the NF-κB pathway increases chondrogenic differentiation by inhibiting osteogenic differentiation in MSCs. …”
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Breast Carcinoma, Intratumour Heterogeneity and Histological Grading, Using Geostatistics by Vénus Sharifi‐Salamatian, Anne de Roquancourt, Jean Paul Rigaut

“…Chromosomal patterns specific of a type of cancer are frequent even though phenotypic spatial heterogeneity is omnipresent. …”
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Hemophagocytic Lymphohistiocytosis in a Patient with Classical Hodgkin Lymphoma by G. Hyun, K. J. Robbins, N. Wilgus, L. Grosso, S. D. Goyal

“…Malignancy-associated HLH should be considered in the differential diagnosis for cancer patients who present with fever, cytopenias, and splenomegaly.…”
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Examining the physical and psychological effects of combining multimodal feedback with continuous control in prosthetic hands by Digby Chappell, Zeyu Yang, Angus B. Clark, Alexandre Berkovic, Colin Laganier, Weston Baxter, Fernando Bello, Petar Kormushev, Nicolas Rojas

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GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma by Yong Huang, HaiLang Zhou, Junwei Zou, Dong Wang

“…Gastric cancer is one of the cancers with the highest incidence in the world. …”
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Statistical Method Based on Bayes-Type Empirical Score Test for Assessing Genetic Association with Multilocus Genotype Data by Yi Tian, Li Ma, Xiaohong Cai, Jiayan Zhu

“…Finally, through extensive simulation studies and analysis of the association between pancreatic cancer and some genes of interest, we show that the proposed robust test method has desirable power and can often identify association signals that may be missed by existing methods.…”
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Ectopic Oral Tonsillar Tissue: A Case Series with Bilateral and Solitary Presentations and a Review of the Literature by Masashi Kimura, Toru Nagao, Terumi Saito, Saman Warnakulasuriya, Hiroyuki Ohto, Akihito Takahashi, Kanji Komaki, Yoshiyuki Naganawa

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Social innovations to increase health coverage: evidence from a crowdsourcing contest in Ghana by Joseph D Tucker, Phyllis Dako-Gyeke, Phyllis Awor, Emmanuel Asampong, Kwabena Opoku-Mensah, Philip Teg-Nefaah Tabong

“…These submissions can be put into three main themes: technology and strengthening (eg, mHealth for cervical cancer screening, video directly observed therapy), inclusiveness and reaching the marginalised (people with disability and infertility) and data utilisation for project improvement (seasonal calendar to reduce morbidity and mortality of children under 5 for malaria, diarrhoea and pneumonia).Conclusion In conclusion, this study shows that solutions to local problems exist. …”
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Implicit bias assessment by career stage in medical education training: a narrative review by Alisha Crump, May Saad Al-Jorani, Sunya Ahmed, Ekas Abrol, Shikha Jain

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Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4 by Zheng-Cai Jia, Bing Ni, Ze-Min Huang, Yi Tian, Jun Tang, Jing-Xue Wang, Xiao-Lan Fu, Yu-Zhang Wu

“…MAGE-A antigens belong to cancer/testis (CT) antigens that are expressed in tumors but not in normal tissues except testis and placenta. …”
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The presence of elafin, SLPI, IL1-RA and STNFα RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation by U. Westin, M. Nyström, I. Ljungcrantz, B. Eriksson, K. Ohlsson

“…We have now found the presence of elafin and SLPI in squamous cell carcinomas of the upper respiratory tract (tonsillar, hypopharyngeal, tongue, mouth floor, gingival and laryngeal cancer). Significantly higher amounts of SLPI and elafin are present in well-differentiated and moderately differentiated tumours than in poorly differentiated tumours (p<0.0001 and p<0.0015). …”
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HSP90 inhibitors promote cell death by degrading Met and BCR::ABL1 in both imatinib-resistant and -sensitive chronic myeloid leukemia cells by Masanobu Tsubaki, Taira Matsuo, Rie Komori, Noriaki Nagai, Tetsushi Yamamoto, Shozo Nishida

“…Heat shock protein 90 (HSP90) functions as a molecular chaperone and is known for its overexpression in various types of cancer, thereby HSP90 is a potential candidate for the treatment of BCR::ABL1 TKI-resistant and -sensitive CML. …”
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Design, Synthesis and Pharmacological Screening of β-Amino-, Thiadiazole/Thiadiazine-Phosphonate Based Triazole Motifs as Antimicrobial/Cytotoxic Agents by Abdou Wafaa M., Ganoub Neven A., Sabry Eman

“…The results showed that all synthesized compounds reflected remarkable antitumor activity against breast (especially MDA-MB-231/ATCC and BT-549), and prostate carcinoma cell lines (PC-3 and DU-145), whereas a moderate to good effect on ovarian and liver cancer cells was observed.…”
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Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System by Bella S. Guerrouahen, Heba Sidahmed, Asma Al Sulaiti, Moza Al Khulaifi, Chiara Cugno

“…Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development.…”
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Colonic growth factors (G-CSF, GM-CSF) and chemokines (MCP-1, MIP-1β) in severe ulcerative colitis by Yevgeny A. Konovich, K. Ye. Shirokikh, M. V. Shapina, Igor L. Khalif

“…Biopsy specimens of uninvolved colonic mucosa resected in 10 cancer patients were used as a control. Results. Growth factor and chemokine levels were significantly elevated in colonic biopsy specimens of UC patients in comparison to that of controls: G-CSF 52,5±17,0 and 0,4±0,1 pg/10 mg (p MIP-1β - in 17 (89,4%) and 12 (63,1%) of 19 colonic biopsies of UC patients with severe inflammatory activity. …”
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Automated karyogram analysis for early detection of genetic and neurodegenerative disorders: a hybrid machine learning approach by Sumaira Tabassum, M. Jawad Khan, Javaid Iqbal, Asim Waris, M. Adeel Ijaz

“…Anomalous chromosomes are the cause of genetic diseases such as cancer, Alzheimer's, Parkinson's, epilepsy, and autism. …”
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Development of a New Questionnaire to Assess the Social Impact of Non-communicable Diseases by Ishani Hanspal, Farah Naaz Fathima, Karthik Murali, Abhay Sood, Fathima Ayoob, Tinku Thomas

“…Material and Methods: A cross-sectional study was conducted among patients and caregivers seeking care at a tertiary care hospital for diabetes, hypertension, chronic obstructive pulmonary disease (COPD), stroke, coronary artery disease (CAD), and cancer. Thirty patients each with the above diseases were administered Cousineau Self-Perceived Burden Scale to assess perceived burden among patients, Caregiver Burden Scale to assess caregiver burden, EuroQol-5D-3L to assess the quality of life, and face validated questions of sociodemographic details, cost of healthcare, and stress due to disease. …”
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Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome) by Majid Alfadhel, Bashayr S. Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S. Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

“…Abstract Sperm-associated antigen 9 (SPAG9) is a member of cancer-testis antigen, having characteristics of a scaffold protein, which is involved in the c-Jun N-terminal kinase JNK signaling pathway, suggesting its key involvement in different physiological processes, such as survival, apoptosis, tumorigenesis, and cell proliferation. …”
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Immunomodulatory Properties of HLA-G in Infectious Diseases by Laurence Amiot, Nicolas Vu, Michel Samson

“…The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. …”
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Preserving the Mucosa to the Maximum Possible Extent for Endoscopic Submucosal Dissection of Subcircumferential Superficial Esophageal Carcinoma by Masaya Uesato, Kentarou Murakami, Yoshihiro Nabeya, Kazunori Fugo, Hisahiro Matsubara

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