Cardamom extract alleviates tamoxifen-induced liver damage by suppressing inflammation and pyroptosis pathway by Wedad S. Sarawi, Hala A. Attia, Afraa Alzoubi, Nour Alanazi, Raeesa Mohammad, Rehab A. Ali

“…Abstract Tamoxifen (TAM) is extensively used to manage estrogen receptor-positive breast cancer. Despite its effectiveness, its administration can negatively impact various organs, including the liver. …”
Get full text

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach by Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia

“…The pathways of Eicosanoid Synthesis, TGF-beta signaling pathway, Prostaglandin Synthesis and Regulation, and Integrated Pancreatic Cancer Pathway were found to be significantly dysregulated in the progression of T2D. …”
Get full text

Reconstrucción mamaria postmastectomía subcutánea con patrón de marcaje Wise. Presentación de un caso by Raquel Rojas Bruzón, Yulexis Hechavarría Jiménez, Annarelis Pérez Pupo, Aracely Lores Cruz

“…La mastectomía reductora de riesgo, también conocida como mastectomía profiláctica, consiste en extirpar la mayor cantidad de tejido posible de una mama sana para reducir el riesgo potencial de desarrollar cáncer. Se presenta el caso de una paciente de 30 años de edad, de color de piel negra, multípara y con antecedentes de padecer desde muy joven enfermedad macroquística de mamas. …”
Get full text

Association between a Primitive Brain Tumor and Cerebral Aspergillosis by Siegfried Hélage, Charles Duyckaerts, Danielle Seilhean, Jean-Jacques Hauw, Jacques Chiras

“…It can arise in immunocompetent patients treated with prolonged corticotherapy or chemoradiotherapy for cancer. A case of lethal cerebral aspergillosis in a patient with an infiltrative glioma treated with corticotherapy and radiotherapy is reported. …”
Get full text

Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 by Hilmi Farhan Ramadhani, Annisa Annisa, Aryo Tedjo, Dimas R. Noor, Wisnu Ananta Kusuma

Get full text

AMEND 2.0: module identification and multi-omic data integration with multiplex-heterogeneous graphs by Samuel S. Boyd, Chad Slawson, Jeffrey A. Thompson

“…AMEND was applied to two real-world multi-omic datasets: renal cell carcinoma data from The cancer genome atlas and an O-GlcNAc Transferase knockout study. …”
Get full text

Inonotus hispidus (Bull.) P. Karst. - bioecological characteristics, significance and possibility of use for medical purposes (medicinal properties) by Radulović Zlatan, Karadžić Dragan, Milenković Ivan

“…The fungus I. hispidus has a large number of compounds that have potential applications in the treatment of various diseases in humans, commonly in the treatment of various types of cancer.…”
Get full text

Pathological margins and advanced cutaneous squamous cell carcinoma of the head and neck by T. J. Phillips, B. N. Harris, M. G. Moore, D. G. Farwell, A. F. Bewley

“…Abstract Objective The recommended treatment for cutaneous squamous cell cancer (CuSCC) of the head and neck is Mohs surgical excision or wide local excision. …”
Get full text

Pepsinogen Serology and Gastritis OLGA Staging in Mucosal Atrophy Assessment: A Cross-Sectional Study Involving East China Endoscopy Population by Junjun Xia, Zhenzhen Liu, Kaiguang Zhang

“…The histological gastric stage (OLGA) plays an important role in evaluating gastric atrophy, a symptom which suggests a risk of gastric cancer (GC). However, gastroscopy is an invasive examination, which has limited application in populations undergoing physical examination. …”
Get full text

Tumor Markers in Pleural Fluid: A Comprehensive Study on Diagnostic Accuracy by Vladimir Aleksiev, Daniel Markov, Kristian Bechev

“…These effusions are a leading cause of debilitating dyspnea and a diminished quality of life among cancer patients, with distant metastasis to the pleural layers occurring in about 20% of cases during treatment. …”
Get full text

Characterization of Malignant Melanoma Using Vibrational Spectroscopy by Ziad Hammody, Ranjit Kumar Sahu, Shaul Mordechai, Emanuela Cagnano, Shmuel Argov

“…Malignant melanoma, a malignant neoplasm of epidermal melanocytes is the third most common skin cancer. In many cases, melanoma develops from nevus, which is considered as the nonmalignant stage. …”
Get full text

DVGEDR: a drug repositioning method based on dual-view fusion and graph enhancement mechanism in heterogeneous networks by Dongjiang Niu, Lianwei Zhang, Beiyi Zhang, Qiang Zhang, Shanyang Ding, Hai Wei, Zhen Li

“…In case study, DVGEDR identifies 10 new candidate drugs for breast cancer and COVID-19, demonstrating not only superior performance in experimental settings but also potential therapeutic advantages in clinical environments. …”
Get full text

SiameseNet based on multiple instance learning for accurate identification of the histological grade of ICC tumors by Zhizhan Fu, Fazhi Feng, Xingguang He, Tongtong Li, Xiansong Li, Jituome Ziluo, Zixing Huang, Jinlin Ye

“…BackgroundAfter hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Timely and accurate identification of ICC histological grade is critical for guiding clinical diagnosis and treatment planning.MethodWe proposed a dual-branch deep neural network (SiameseNet) based on multiple-instance learning and cross-attention mechanisms to address tumor heterogeneity in ICC histological grade prediction. …”
Get full text

Novel transcripts of EMT driving the malignant transformation of oral submucous fibrosis by Smitha Sammith Shetty, Kanaka Sai Ram Padam, Mohit Sharma, Adarsh Kudva, Pratik Patel, Raghu Radhakrishnan

“…The curated EMT genes were correlated with functional cancer states and subjected to clustering to identify candidate genes. …”
Get full text

HAVCR1 Affects the MEK/ERK Pathway in Gastric Adenocarcinomas and Influences Tumor Progression and Patient Outcome by Ji Xue, Ying Li, Jianfeng Yi, Hong Jiang

“…Especially, HAVCR1 overexpression promotes the development and progression of several human cancers. Hence, we aimed to detect the effects of HAVCR1 on gastric adenocarcinoma (GAC). …”
Get full text

DDX24 promotes lymphangiogenesis and lymph node metastasis via AGRN production in cervical squamous cell carcinoma by Baibin Wang, Yuan Zhuang, Chongrong Weng, Yanhui Jiang, Bingfan Xie, Lijie Wang, Yingying Dong, Xiangpei Fang, Jianzhong He, Xiaojin Wang, Huanhuan He, Yong Chen, Huilong Nie, Yanjie Yin

Get full text

Recurrent Giant Malignant Phyllodes Tumor of the Breast by Erik Kudela, Karol Kajo, Erik Kozubik, Tomas Rokos, Terezia Pribulova, Jan Danko, Eva Kudelova, Igor Homola, Pavol Slavik, Barbora Macurova, Kamil Biringer

Get full text

Cells Grouping Detection and Confusing Labels Correction on Cervical Pathology Images by Wenbo Pang, Yi Ma, Huiyan Jiang, Qiming Yu

“…Cervical cancer is one of the most prevalent cancers among women, posing a significant threat to their health. …”
Get full text

Surgical management of metastatic lesions in the proximal femur: a systematic review by Afrim Iljazi, Mads Sten Andersen, Stig Brorson, Michael Mørk Petersen, Michala Skovlund Sørensen

“…Purpose: The proximal femur is a frequent site of cancer dissemination in the extremities. Patients treated surgically for skeletal metastases have poorer overall health compared to other orthopedic patients, with only one-third expected to survive two years post-surgery. …”
Get full text

Cerebellar re-irradiation after whole brain radiotherapy significant symptom relief with minimal toxicity in metastatic brain patients by Ory Haisraely, Marcia Jaffe, Yaacov Richard Lawerence, Alicia Talianksy, Alicia Taliansky

“…The cohort’s median age was 53 years, with breast cancer being the most prevalent histology (71%). Symptom improvement occurred in 75% of patients, with relief rates of 84.6% for nausea, 80% for headache, and 58.3% for dizziness. …”
Get full text