Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors by Alshimaa A. Y. Ahmed, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif

“…IntroductionThis work outlines the design, synthesis, and biological evaluation of a new series of benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit the EGFR pathway.MethodsThe research assesses the antiproliferative efficacy of compounds 6a-i and 10a-i against various cancer cell lines.Results and DiscussionThe research emphasizing hybrids 6i and 10e for their remarkable activity, with GI50 values of 29 nM and 25 nM, respectively. …”
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Phytochemical Constituents and Biological Activities of Jasonia glutinosa L.: The First Report for the Plant Growing in North Africa by Hamdoon A. Mohammed, Abdulnaser Kh. Abdulkarim, Abdullah D. Alamami, Fatma A. Elshibani

“…The in vitro antioxidant assays showed 265.55, 513.32, and 27.10 μM Trolox eq/mg of extract in the ABTS, ORAC, and FRAP assays, respectively. Cancer cell growth inhibitions of 9.23, 11.42, and 34.01% at a concentration of 100 μg/mL against MCF-7, HepG2, and PANC-1 cell lines were obtained, which is considered a weak cytotoxic effect when compared to the standard anticancer agent, doxorubicin (DOX). …”
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Sub-Tenon Injections of Triamcinolone Acetonide Had Limited Effect on Cystoid Macular Edema Secondary to Nanoparticle Albumin-Bound-Paclitaxel (Abraxane) by Naoki Matsuoka, Hiruma Hasebe, Tetsuji Mayama, Takeo Fukuchi

“…A 39-year-old Japanese woman with breast cancer presents with decreased vision in both eyes while receiving nab-paclitaxel. …”
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GC-MS Analysis of Bioactive Compounds in Methanolic Extracts of Papaver decaisnei and Determination of Its Antioxidants and Anticancer Activities by Ahmed Aj. Jabbar, Fuad O. Abdullah, Kamaran K. Abdulrahman, Yaseen Galali, Abdullah Sh. Sardar

“…The current study investigates the methanol (99.9%) extracts (10 μg/mL) of roots, leaves, and flowers of Papaver decaisnei in terms of phytochemistry by gas chromatography-mass spectrophotometry GC-MS, in vitro antioxidant activity by radical scavenging and reducing power assays, and finally, the anticancer actions as IC50 (inhibitory concentration at 50%) against human colorectal adenocarcinoma (Caco-2), mammary cancer cells (MCF-7), and human cervical carcinoma (HeLa) cells. …”
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The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma by Mircea Tampa, Cristina Iulia Mitran, Madalina Irina Mitran, Ilinca Nicolae, Adrian Dumitru, Clara Matei, Loredana Manolescu, Gabriela Loredana Popa, Constantin Caruntu, Simona Roxana Georgescu

“…Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with a complex but not fully understood pathogenesis. …”
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ANALYSIS OF THE INTRAOPERATIVE ULTRASOUND RESULTS IN THE SURGICAL TREATMENT OF RENAL TUMORS by A. D. Karnin, A. A. Kostin, S. O. Stepanov, N. V. Vorobyev, P. D. Bespalov, V. O. Dimitrov

“…Possibilities of IOUS application in the surgical treatment of kidney tumor according to the results of examination and surgical treatment of 145 patients (95 men and 50 women) diagnosed with kidney cancer were evaluated. The patients were divided into 2 groups: group 1 (comparisons) — 76 patients; during the examination and treatment, the IOUS method was not used, group 2 (basic) — 69 patients, who during the surgical treatment used the IOUS method to further clarify the localization, the size and boundaries of the tumor formation.Results. …”
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Beyond Humanoid Prosthetic Hands: Modular Terminal Devices That Improve User Performance by Digby Chappell, Barry Mulvey, Shehara Perera, Fernando Bello, Petar Kormushev, Nicolas Rojas

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Interventional Protocol for Treatment of Complications after Esophagojejunostomy for Esophagogastric Carcinoma by Yonghua Bi, Jindong Li, Mengfei Yi, Zepeng Yu, Xinwei Han, Jianzhuang Ren

“…During follow-up, 14 patients died of cancer recurrence, and one died of severe pulmonary infection. …”
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Non-viral systems for intracellular delivery of genome editing tools by I. H. Shaikhutdinov, P. V. Ilyasov, O. V. Gribkova, L.  V. Limareva

“…Conventional vectors are not always suitable for this purpose due to a limited cargo volume, risks related to cancer and immune reactions, toxicity, a need for high-purity viral material and quality control, as well as a possibility of integration of the virus into the host genome leading to overexpression of the vector components and safety problems. …”
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Machine Learning-Based Integrated Analysis of PANoptosis Patterns in Acute Myeloid Leukemia Reveals a Signature Predicting Survival and Immunotherapy by Lanlan Tang, Wei Zhang, Yang Zhang, Wenjun Deng, Mingyi Zhao

“…Our findings disclosed significant associations between the identified PANRGs, gene clusters, patient survival, immune system, and cancer-related biological processes and pathways. …”
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Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota by Jianwei Wu, Jing Zhang, Gang Huang, Yinglian Zhong, Yi Yang, Peng Deng

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Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1 by Joanna Lecka, Michel Fausther, Beat Künzli, Jean Sévigny

“…Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), like other ectonucleotidases, controls extracellular nucleotide levels and consequently their (patho)physiological responses such as in thrombosis, inflammation, and cancer. Selective NTPDase1 inhibitors would therefore be very useful. …”
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Pharmaceutical Humanities and Narrative Pharmacy: An Emerging New Concept in Pharmacy by Mita Banerjee, Thomas Efferth

“…Many complex diseases (e.g., cancer, neurological diseases, and mental disorders) remain uncurable for many patients by current pharmacotherapies, and the old beaten paths in our therapeutic thinking may at least partly have to be left behind. …”
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A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes by Zhen Xiong, Liwen Zhang, Wei Fan

“…In LUAD patients, the strong connection between the risk score and overall survival was further verified in three other GEO data sets. TMB and cancer stem cell infiltration were shown to be significantly higher in the high-risk group in comparison to the low-risk group. …”
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Inhibition of Horseradish Peroxidase Activity by Boroxine Derivative, Dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] by Jelena Ostojic, Safija Herenda, Semira Galijasevic, Borivoj Galic, Mladen Milos

“…Recently research shows that horseradish peroxidase, HRP, when combined with other compounds, is highly reactive toward different human tumour cells and that better understanding of catalytic mechanism and inhibition HPR could lead to a new targeted cancer therapy. Thus, the inhibition of HRP activity by dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] was investigated for possible explanation of previously observed antitumour activities of this promising drug. …”
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Morphology of the Myoepithelial Cell: Immunohistochemical Characterization from Resting to Motile Phase by Germana Beha, Giuseppe Sarli, Barbara Brunetti, Francesco Sassi, Domenico Ferrara, Cinzia Benazzi

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Association of Interleukin-18 Gene Polymorphism with Susceptibility to Visceral Leishmaniasis in Endemic Area of Bihar, an Indian Population by Dinesh Kumar, Puja Tiwary, Jaya Chakravarty, Shyam Sundar

“…Genetic polymorphisms in the IL-18 gene have been found to be associated with its expression in cancer, tuberculosis, HBV infection, and various other diseases. …”
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A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens by Gina Bouchard, Weiruo Zhang, Ilayda Ilerten, Irene Li, Asmita Bhattacharya, Yuanyuan Li, Winston Trope, Joseph B. Shrager, Calvin Kuo, Michael G. Ozawa, Amato J. Giaccia, Lu Tian, Sylvia K. Plevritis

“…We perform cell-pair colocalization analysis on multiplexed immunofluorescence images of assembloids constructed with lung adenocarcinoma (LUAD) organoids and cancer-associated fibroblasts derived from human tumors. …”
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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting. by Kelly Lim, Winnie L Kan, Pramod C Nair, Monika Kutyna, Angel F Lopez, Timothy Hercus, David M Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas

“…Chronic myelomonocytic leukemia (CMML) is a rare blood cancer of older adults (3 in every 1,000,000 persons) characterized by poor survival and lacking effective mutation-specific therapy. …”
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Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review by Virginie Lienart, Birgit Carly, Xin Kang, Laura Guzy, Anna-Maria Sajovitz, Fabienne Liebens

“…Breast density (BD) is recognized as one of the strongest independent risk factors of breast cancer (BC). Unlike most other risk factors, BD can be modified, suggesting that it may be a biomarker for preventive interventions. …”
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