Colgajo bilobulado de Esser modificado para su empleo en localización atípica. Presentación de un caso by Carla María García San Juan, José Daniel Gil Milá

“…Es la segunda neoplasia cutánea más frecuente dentro de las de tipo no melanoma, con predominio de 2,1: 1 en la relación hombre-mujer y el cáncer que con más frecuencia causa metástasis. Esta presentación de caso tiene como objetivo describir la técnica quirúrgica del colgajo bilobulado de Esser para la resección de un carcinoma epidermoide situado en el canto externo del ojo, técnica no indicada para esta región de la cara, pero con la se obtuvo un resultado satisfactorio en el tratamiento a una paciente de color de piel blanca, de 75 años que acudió al Servicio de Cirugía Máxilofacial del Hospital General de Cienfuegos, remitida por el Servicio de Dermatología, debido a la presencia de una lesión ulcerada de aproximadamente 5 cm., de diámetro localizada en la mencionada región. …”
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Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives by Zahra Khosroabadi, Samaneh Azaryar, Hassan Dianat-Moghadam, Zohreh Amoozgar, Mohammadreza Sharifi

“…Generated data of the transcriptional profile of the AML could even allow the development of cancer vaccines and CAR T-cell therapies while saving valuable time and alleviating dangerous side effects of chemotherapy and HSCT in vivo. …”
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Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors by Banan Mohammed, khalid Abdulfattah Khattab, Payman Salim

“…Background: Cluster of differentiation 44 (CD44) is the most commonly reported immune marker of the cancer stem cells in renal cell carcinoma.Objectives: To assess the frequency of CD44 expression in renal tumors, to assess the expression of CD44 in different histological types, and to detect its association with variable clinicopathological parameters.Materials and methods: In this retrospective case series study, 76 cases of primary renal tumors were obtained by nephrectomy, and a study of CD44 was done by using the immunohistochemical technique.Results: The age of the patients ranged from 29-82 years with a mean of 54.8 ±11.96 with a male to female ratio of 1.05:1. …”
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“Don’t leave us behind”: a qualitative study exploring the feasibility of a palliative care training program for non-health caregivers in Honduras by Sheryl Ruiz, Martin Stafström, Leda Parham, Luis Orellana

“…Data was collected through individual semi-structured interviews with 25 participants belonging to different key groups: patients diagnosed with cancer, non-health caregivers, PC experts, and health-related decision makers. …”
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A Human/Murine Chimeric Fab Antibody Neutralizes Anthrax Lethal Toxin In Vitro by Guipeng Ding, Ximin Chen, Jin Zhu, Nicholas S. Duesbery, Xunjia Cheng, Brian Cao

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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 by Shang-Jung Cheng, Temitope Gafaar, Jijin R. A. Kuttiyatveetil, Aleksandr Sverzhinsky, Carla Chen, Minghui Xu, Allison Lilley, John M. Pascal, Anthony K. L. Leung

“…This fragmented stress granule phenotype is also apparent in PARP13 variants with cancer-associated single-nucleotide polymorphisms (SNPs) that disrupt PAR binding. …”
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Gastric Polyps and Atrophic Gastritis by I. Yu. Kolesnikova, A. S. Novikova

“…The H. pylori eradication, in contrast to anti-secretory therapy, allows the containment of chronic gastritis and is a critical measure in gastric cancer prevention.…”
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From data to diagnosis: leveraging deep learning in IoT-based healthcare by Miracle A. Atianashie, Chukwuma Chinaza Adaobi

“…Furthermore, the implementation of deep learning technologies in healthcare IoT has proven effective in the early detection of critical health conditions, including cancer and neurodegenerative diseases, through sophisticated analysis of medical images and physiological data. …”
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Primary pulmonary meningioma — a rare lung tumor by Galust A. Baksiyan, Alexander A. Zavialov, Sergey V. Lishchuk

“…CLINICAL CASE DESCRIPTION: The patient А. (54 years of age) with a history of combined treatment 9 years ago due to being diagnosed with рТ2аN1М0, stage IIIB cervical cancer. According to the results from the computed tomography of the chest cavity organs, in segments S8/9 of the lower lobe of the right lung, the findings included a subpleural solid mass lesion with the size of 14×11 mm. …”
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Total Body Irradiation without Chemotherapy as Conditioning for an Allogeneic Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia by Sultan Altouri, Mitchell Sabloff, David Allan, Harry Atkins, Lothar Huebsch, Dawn Maze, Rajiv Samant, Christopher Bredeson

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Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy by Xinwei Li, Xinwei Li, Wei Xiong, Zhiyong Xiong, Zhiyong Xiong, Xiaoping Zhang, Xiaoping Zhang, Xiaoping Zhang

“…Renal cell carcinoma is a common type of cancer, with approximately 30% of patients potentially developing metastatic disease. …”
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Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces by W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk

“…Antibody-mediated delivery of immunogenic viral CD8+ T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. …”
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Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia by David H. Adler, Melissa Wallace, Thola Bennie, Beau Abar, Tracy L. Meiring, Anna-Lise Williamson, Linda-Gail Bekker

“…Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. …”
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Basal Ganglia Disease and Visuospatial Cognition: Are There Disease-Specific Impairments? by Erich Mohr, Jules J. Claus, Pim Brouwers

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Contrast-Enhanced Dynamic MR Imaging of Uterine Fibroids as a Potential Predictor of Patient Eligibility for MR Guided Focused Ultrasound (MRgFUS) Treatment for Symptomatic Uterine... by Sang-Wook Yoon, Chan Lee, Kyoung Ah Kim, Sang Heum Kim

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Cytokine Patterns in Brain Tumour Progression by Radu Albulescu, Elena Codrici, Ionela Daniela Popescu, Simona Mihai, Laura Georgiana Necula, Daniel Petrescu, Mihaela Teodoru, Cristiana Pistol Tanase

“…The body’s response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. …”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…The nanocomplexes were precisely co-assembled in water to stably co-deliver Mn2+ and PPa, enabling tumor-specific release and fluorescence recovery.ResultsFollowing laser irradiation, the activated PPa significantly enhanced the killing effects on primary cancer cells. Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy.…”
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Outcomes of Human Papilloma Virus Vaccination in a Private Women Health Clinic in Lebanon by Muhieddine Seoud, Iman Jaafar, Rayan Ghanem, Christiane Soubhieh, Abdallah Adra, Anwar Nassar, Ali Khalil

“…The study aims to report on the feasibility and associated adverse events of HPV-Vaccination (HPVV) in a private clinic setting in Lebanon and, when available, the results of subsequent cervical cancer screening. Methods. Opportunistic HPV vaccination is offered at the Women’s Health Center of the AUBMC. …”
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Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…Ataxia Telangiectasia (A-T) is a rare, autosomal recessive genetic disorder characterized by a variety of symptoms, including progressive neurodegeneration, telangiectasia, immunodeficiency, and an increased susceptibility to cancer. It is caused by bi-allelic mutations impacting a gene encoding a serine/threonine kinase ATM (Ataxia Telangiectasia Mutated), which plays a crucial role in DNA repair and maintenance of genomic stability. …”
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Fiberoptic-Coupled Spectrofluorometer with Array Detection as a Process Analytical Chemistry Tool for Continuous Flow Monitoring of Fluoroquinolone Antibiotics by Nader Shokoufi, Maryam Vosough, Mona Rahimzadegan-Asl, Atefeh Abbasi-Ahd, Mahsa Khatibeghdami

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