Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study by Wuguang Zhang, Wenqian Gong, Changhai Wu, Mengting Li, Xiaolong Tu

“…Colorectal signet ring cell carcinoma (SRCC) is a rare and distinct subtype of colorectal cancer (CRC), with extremely poor prognosis and aggressive tumor biological behavior. …”
Get full text

Rates and causes of 30-day readmission and emergency room utilization following head and neck surgery by Vincent Wu, Stephen F. Hall

Get full text

Effects of group music sessions on cognitive and psychological functions in healthy older adults by Takamitsu Shinada, Michio Takahashi, Akari Uno, Keishi Soga, Yasuyuki Taki, Yasuyuki Taki

Get full text

Combined Effects of 2-Methoxyestradiol (Hypoxia-Inducible Factor 1α Inhibitor) and Dasatinib (A Second-Generation Tyrosine Kinase Inhibitor) on Chronic Myelocytic Leukemia Cells by Yuexian Zhang, Heng Chen, Yunfeng Shen, Xin Zhou

“…The activation of this gene mostly marks a poor outlook for cancer patients. To clarify the therapeutic effect of inhibiting this gene on CML, the present study is aimed at exploring the treatment effects of 2-methoxyestradiol (2-ME2), dasatinib alone, and combined both on K-562 cells and the possible mechanism of 2-ME2 in treating the disorder. …”
Get full text

Role of Microbes and Nanomaterials in the Removal of Pesticides from Wastewater by Arpita Roy, Madhura Roy, Saad Alghamdi, Anas S. Dablool, Angham Ahmed Almakki, Ismat H. Ali, Krishna Kumar Yadav, Md. Rabiul Islam, Marina M. S. Cabral-Pinto

“…Long-term exposure to pesticides can cause neurological disorders, reproductive complications, cancer, immunological, and pulmonary diseases. The use of pesticides has dramatically surged in agricultural as well as nonagricultural practices. …”
Get full text

Is hypercalcaemia immediately life-threatening? A prospective study by David Trewick, Mathilde Le Borgne, Julie Regnault, Camille Guimard

“…Results: The median calcium concentration was 3.3 mmol/L (3.1–3.7). Cancer was the first cause of hypercalcaemia. No patient presented a life-threatening cardiac arrhythmia during their stay in the ED. …”
Get full text

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length by Fan Zhang, De Cheng, Kenneth I. Porter, Emily A. Heck, Shuwen Wang, Hui Zhang, Christopher J. Davis, Gavin P. Robertson, Jiyue Zhu

“…These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.…”
Get full text

Imaging cell spheroid clusters: An MRI protocol for non-invasive standardized characterization by Rebecca Wißmann, Petros Martirosian, Marina Danalache, Gerd Grözinger, Fritz Schick, Stefanie Elser

“…Despite its limited spatial resolution, this method adeptly reveals information about the composition and vitality of stem cell and cancer spheroids and their micro-environment in a non-invasive manner. …”
Get full text

Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design by Muhammad Umar, Haroon Afzal, Asad Murtaza, Li-Ting Cheng

“…The lipidation process is essential for TLR2 recognition and the activation of robust immune responses, positioning lipidated bacterial proteins as potent immunomodulators and adjuvants for vaccines against bacterial-, viral-, and cancer-related antigens. The structural diversity and cleavage pathways of bacterial SPs are critical in determining lipidation efficiency and protein localization, influencing their immunogenic potential. …”
Get full text

Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models by Yiqun Ma, Shuchi Xia, Annan Hu, Qianyi Zhang, Zhengzhong Shao, Bo Tian, Qinrui Lin

“…Abstract Background Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imaging emerges as a promising modality due to its high spatial resolution and signal stability. …”
Get full text

Diagnosis dan Penatalaksanaan Karsinoma Sel Skuamosa Glotis Stadium Dini by Sukri Rahman Rahman, Bestari Jaka Budiman Jaka Budiman, Delva Swanda Swanda

“…</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>Laryngeal carsinoma is the common head and neck cancer. More than 90% of laryngeal cancers are squamous cell carcinoma, if the early detected the cure rate can the better. …”
Get full text

Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines by Musthahimah Muhamad, Nurhidayah Ab.Rahim, Wan Adnan Wan Omar, Nik Nur Syazni Nik Mohamed Kamal

“…Biogenic silver nanoparticles (AgNPs-GA) were successfully synthesised using Garcinia atroviridis leaf extract as a reducing agent, which has ethnopharmacological claims against various diseases including cancer. Aim of the Study. Aim of the study is to discover whether AgNPs-GA has cytotoxic and genotoxic effects on cancerous (A549) and noncancerous (BEAS-2B) human lung cells. …”
Get full text

Structural modeling of NAD+ binding modes to PARP-1 by N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko

“…Inhibitors of poly (ADP-ribose) polymerase have been shown to be effective in improvement of radiation therapy and chemotherapy of cancer in clinical testing. Development of new poly (ADP-ribose) polymerase-1 inhibitors based on derivatives of natural compounds such as NAD+ represents a novel and promising strategy. …”
Get full text

Análise Temporal e de Fatores Sociodemográficos da Mortalidade por Neoplasias da População Idosa no Brasil, no Período de 2011 a 2020 by Felipe Carneiro de Souza, Cleber Nascimento do Carmo

Get full text

Primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a case report by Eya Slama, S. Ben Hamida, S. Zaouga, H. Elloumi, I. Cheikh, A. G. Dahak, M. Missaoui, A. Chelibi, I. Ganzoui

“…Duodenal bulb adenocarcinoma is a rare malignancy of the gastrointestinal tract. This cancer often presents with an insidious onset, making it challenging to diagnose early. …”
Get full text

p53 dosage can impede KrasG12D- and KrasQ61R-mediated tumorigenesis. by Özgün Le Roux, Jeffery I Everitt, Christopher M Counter

“…Loss of the Trp53 gene encoding the tumor suppressor p53 enhances the ability of oncogenic Kras to initiate tumorigenesis in carcinogen and genetic models of lung cancer. Conversley, an extra copy of Trp53 (Super p53) was recently shown to suppress Kras-induced tumorigenesis in a genetic model of this disease. …”
Get full text

Synthesis, Characterization, and In Vitro Drug Delivery Capabilities of (Zn, Al)-Based Layered Double Hydroxide Nanoparticles by Vinay J. Nagaraj, Xiaodi Sun, Jiten Mehta, Mac Martin, Thi Ngo, Sandwip K. Dey

“…There is an urgent need for the development of alternative strategies for effective drug delivery to improve the outcome of patients suffering from deadly diseases such as cancer. Nanoparticles, in particular layered double hydroxide (LDH) nanoparticles, have great potential as nanocarriers of chemotherapeutic molecules. …”
Get full text

Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages by Tao Guo, Yukun He, Weijie Ma, Zhisu Liu, Quanyan Liu

“…To understand the feasibility and efficacy of treatment with SAMe in patients with hepatitis B-related HCC with different Barcelona Clinic Liver Cancer (BCLC) stages. Methods. We retrospectively enrolled 697 patients with BCLC early-stage (stages 0-A) and advanced-stage (stages B-C) HCC who underwent SAMe therapy (354 cases) or no SAMe therapy (343 cases). …”
Get full text

Medullary Thyroid Carcinoma with Micronodular Lung Metastases: A Case Report with an Emphasis on the Imaging Findings by Nina Ventura, Edson Marchiori, Gláucia Zanetti, Antonio Muccillo, Mariana Leite Pereira, Guilherme Abdalla, Pedro Martins, Carolina Lamas Constantino, Rodrigo Canellas, Viviane Brandão, Romulo Varella de Oliveira

“…Here, we present a case of a micronodular radiographic pattern in metastatic medullary thyroid cancer in order to enhance awareness of the disease process. …”
Get full text

Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The model of bacterial involvement in colorectal cancer progression is under study. Besides, the increasing attention of doctors and scientists is attracted to the issue intestinal microflora changes at antibiotic treatment. …”
Get full text