Biphasic Chromatin Structure and FISH Signals Reflect Intranuclear Order by Jyoti P. Chaudhuri, Eva Kasprzycki, Mathew Battaglia, John R. McGill, Anton Brøgger, Joachim-U. Walther, Albrecht Reith

“…Similarly, a genome-wide monoallelic replication may tilt the balance of heterozygosity resulting in aneusomy, initiating early events in malignant transformation and in predicting cancer mortality.…”
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Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…Our semantic modeling for ethnicity-specific SNPs showed interesting results in the three categories, including three diseases ("AIDS-associated nephropathy," "Hypertension," and "Pelvic infection"), one drug ("Methylphenidate"), and five pathways ("Hemostasis," "Systemic lupus erythematosus," "Prostate cancer," "Hepatitis C virus," and "Rheumatoid arthritis"). …”
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Screening of multi deep learning-based de novo molecular generation models and their application for specific target molecular generation by Yishu Wang, Mengyao Guo, Xiaomin Chen, Dongmei Ai

“…Moreover, we evaluated the performance of these NLP-based generation models and another new model architecture based on a selective state space and selected the best approach jointing a transfer learning strategy for de novo drug discovery to target L858R/T790M/C797S-mutant EGFR in non-small cell lung cancer.…”
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Risk of Exposure to Trace Elements through the Application of Facial Makeup Powders by Selina Ama Saah, Nathaniel Owusu Boadi, Patrick Opare Sakyi, Godfred Darko, Michael Baah Mensah

“…Dermal exposure to trace elements from cosmetics resulted in a lifetime cancer risk (LCR) that was higher than what was considered tolerable (LCR >10−6) due to the presence of Pb, As, and Cr. …”
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Gene Editing in Pluripotent Stem Cells and Their Derived Organoids by Hang Zhou, Yun Wang, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…Gene editing in PSCs creates visualized in vitro models, providing opportunities for examining mechanisms of known and unknown mutations and offering new possibilities for the treatment of cancer, genetic diseases, and other serious or refractory disorders. …”
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Association between Obesity, Serum Lipids, and Colorectal Polyps in Old Chinese People by Wen Yang, Yan Chang, Haiyan Huang, Yuzhu Wang, Xiaohong Yu

“…Background. Colorectal cancer mostly arises from the polyps of colon. The aim of our study was to examine the association of body mass index (BMI) and serum lipids with the colorectal polyps in old Chinese people. …”
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Pulmonary Artery Pseudoaneurysm: A Rare Cause of Fatal Massive Hemoptysis by Himaja Koneru, Sreeja Biswas Roy, Monirul Islam, Hesham Abdelrazek, Debabrata Bandyopadhyay, Nikhil Madan, Pradnya D. Patil, Tanmay S. Panchabhai

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Insights into the mechanism of antiproliferative effects of primaquine-cinnamic acid conjugates on MCF-7 cells by Mabeta Peace, Pavić Kristina, Zorc Branka

“…In our previous paper, we showed that three primaquine-cinnamic acid conjugates composed of primaquine (PQ) residue and cinnamic acid derivatives (CADs) bound directly by an amide linkage (1) or through an acylsemicarbazide spacer (2 and 3) had significant growth inhibitory effects on some cancer cell lines. Compound 1 induced significant growth inhibition in the colorectal adenocarcinoma (SW620), human breast adenocarcinoma (MCF-7) and cervical carcinoma (HeLa) cell lines, while compounds 2 and 3 selectively inhibited the growth of MCF-7 cells. …”
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A Universal Analysis Pipeline for Hybrid Capture-Based Targeted Sequencing Data with Unique Molecular Indexes by Min-Jung Kim, Si-Cho Kim, Young-Joon Kim

“…First, we generated hybrid capture-based data using genomic DNA extracted from tumor tissues of colorectal cancer patients. Sequencing libraries were prepared and pooled together, and an 8-plexed capture library was processed to the enrichment step before 150-bp paired-end sequencing with Illumina HiSeq series. …”
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An In Silico Approach for Evaluating a Fraction-Based, Risk Assessment Method for Total Petroleum Hydrocarbon Mixtures by Nina Ching Y. Wang, Glenn E. Rice, Linda K. Teuschler, Joan Colman, Raymond S. H. Yang

“…Furthermore, the results support the general methodology of mixture risk assessment to assess both cancer and noncancer risk values after the application of fractionation.…”
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Investigation of Arsenic-Stressed Yeast (Saccharomyces cerevisiae) as a Bioassay in Homeopathic Basic Research by Tim Jäger, Claudia Scherr, Ursula Wolf, Meinhard Simon, Peter Heusser, Stephan Baumgartner

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Assistance for the Prescription of Nutritional Support Must Be Required in Nonexperienced Nutritional Teams by Mehdi Ouaïssi, Philippe Grandval, Diane Mege, Anamaria Nedelcu, Gaëlle Hautefeuille, Frédéric Vanhoeve, Bernard Sastre, Igor Sielezneff, Jacques di Costanzo

“…The study included 120 patients bearing a surgical disease in 86.7% of cases and 10% of medical cases. 50% of the patients had cancer. Nutritional status was correctly evaluated in 38.3% by the initial doctors’ diagnosis—consistent with the software’s evaluation. …”
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DCE-MRI and DWI Integration for Breast Lesions Assessment and Heterogeneity Quantification by C. Andrés Méndez, Francesca Pizzorni Ferrarese, Paul Summers, Giuseppe Petralia, Gloria Menegaz

“…In order to better predict and follow treatment responses in cancer patients, there is growing interest in noninvasively characterizing tumor heterogeneity based on MR images possessing different contrast and quantitative information. …”
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Comprehensive Analysis of the Role of SLC2A3 on Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma by Manru Chu, Ke Zheng, Xiaojie Li, Zhiqiang Luo, Xin Yang, Changbo Wei

“…SLC2A3 is upregulated in various cancer types and promotes proliferation, invasion, and metabolism. …”
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Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…This disorder affects approximately 6–20% of individuals, primarily emerging during early adolescence, and considerably increases the risk of conditions such as impaired glucose tolerance, type 2 diabetes, endometrial cancer, cardiovascular diseases, dyslipidemia, and postpartum complications. …”
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Rapid Identification and Systematic Mechanism of Flavonoids from Potentilla freyniana Bornm. Based on UHPLC-Q-Exactive Orbitrap Mass Spectrometry and Network Pharmacology by Wei Cai, Kailin Li, Shihan Qin, Pei Xiong, Jie Peng, Silin Shi, Zaiqi Zhang

“…This finding revealed that P. freyniana possessed 43 flavonoids (40 of them were first reported) with 23 core target genes, which are associated with PI3K-Akt, MAPK, TNF signaling pathway, and pathway in cancer. This study demonstrated the multicompound, multitarget, and multimechanism of P. freyniana, which are very beneficial to develop the further study and utilization of this plant including the material basis and quality control research.…”
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Plant thionins: structure, biological functions and potential use in biotechnology by T. I. Odintsova, M. P. Slezina, E. A. Istomina

“…Thionins are toxic to different types of cells including mammalian cancer cell lines. Transgenic plants expressing thionin genes display enhanced resistance to pathogens. …”
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Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature by Weiming Wang, Baogang Zhang, Zhangli Wu, Chuanling Hou, Mengyao Li, Tianyi Zhang

“…There have been similar cases reported before, involving a 57-year-old male-patient (Sahetia et al. in Ind J Cancer 60:575–577, 2023).…”
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Myeloperoxidase Promoter Polymorphism −463G Is Associated With More Severe Clinical Expression of Cystic Fibrosis Pulmonary Disease by Wanda F. Reynolds, Isabelle Sermet-Gaudelus, Valérie Gausson, Marie-Noëlle Feuillet, Jean-Paul Bonnefont, Gérard Lenoir, Béatrice Descamps-Latscha, Véronique Witko-Sarsat

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Clinical benefits of the 5th intercostal incision in uniportal VATS for female patients by Dalin Wang, Zhilin Luo, Jia Ming

“…A retrospective analysis of 150 female lung cancer patients was conducted, divided into 4 and 5th intercostal incision groups (n = 75 each). …”
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