Enhanced Hepatocarcinogenicity Due to Agonists of Peroxisome Proliferator-Activated Receptors in Senescent Rats: Role of Peroxisome Proliferation, Cell Proliferation, and Apoptosis by Jihan Youssef, Mostafa Badr

“…Exposure to agonists of peroxisome proliferator-activated receptor alpha (PPARα) causes liver cancer in rodents, with aged animals being more susceptible than their younger counterparts to this effect. …”
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Pre-phase treatment with rituximab and high-dose methotrexate to re-evaluate eligibility for intensive induction treatment of frail patients with central nervous system lymphoma by Julia Wendler, Richard I. Lewis, Alexandra Kutilina, Markus Knott, Lisa Kristina Isbell, Elke Valk, Peter Borchmann, Jan-Michel Heger, Gerald Illerhaus, Elisabeth Schorb

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BCL-2 inhibitors in hematological malignancies: biomarkers that predict response and management strategies by Mariam Markouli, Maria N. Pagoni, Panagiotis Diamantopoulos

“…Apoptosis is an essential characteristic of cancer and its dysregular promotes tumor growth, clonal evolution, and treatment resistance. …”
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Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration by Jakub Poloczek, Wojciech Kazura, Ewa Kwaśnicka, Janusz Gumprecht, Jerzy Jochem, Dominika Stygar

“…It is also associated with the leading causes of death, including type 2 diabetes mellitus, cardiovascular diseases, and numerous types of cancer. The mainstay of therapy is a dietary treatment. …”
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Fluconazole-Like Compounds as Potential Antifungal Agents: QSAR, Molecular Docking, and Molecular Dynamics Simulation by Farnaz Salehi, Leila Emami, Zahra Rezaei, Soghra Khabnadideh, Behnaz Tajik, Razieh Sabet

“…Today, fungal infection has become more common disease especially in some cases, such as AIDS, cancer, and organ transplant which the immune system is suppressed. …”
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Dermatological Disorders following Liver Transplantation: An Update by Dipesh Kumar Yadav, Xue li Bai, Tingbo Liang

“…However, the risk is not as high as other solid organ transplantations (SOT), particularly for skin cancer. The liver is considered as an immune privileged organ since it has a low prevalence of humoral rejection in contrast to other SOT, and thus, LT requires a minimal amount of immunosuppressants compared to other SOT recipients. …”
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The impact of innate immune response on the efficacy of oncolytic viruses by Kirill N. Trachuk, Nikolai B. Pestov, Yulia K. Biryukova, Nadezhda M. Kolyasnikova

“…Recently, there have emerged more studies determining the effect of the antiviral immunostimulating mechanisms on the effectiveness of treatment in cancer patients. Stimulation of innate immune cells by an oncolytic virus can initiate an adaptive antitumor immune response, yet at the same time, the antiviral mechanisms of the immune system can limit the spread of the virus, thereby reducing its effectiveness. …”
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Waldenström Macroglobulinemia in Hepatitis C: Case Report and Review of the Current Literature by Ryan Nipp, Aaron Mitchell, Allyson Pishko, Ara Metjian

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A Gel Formulation Containing a New Recombinant Form of Manganese Superoxide Dismutase: A Clinical Experience Based on Compassionate Use-Safety of a Case Report by Lucia Grumetto, Antonio Del Prete, Giovanni Ortosecco, Antonella Borrelli, Salvatore Del Prete, Aldo Mancini

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Apolipoprotein C-II Deposition Amyloidosis: A Potential Misdiagnosis as Light Chain Amyloidosis by Sadichhya Lohani, Emily Schuiteman, Lohit Garg, Dhiraj Yadav, Sami Zarouk

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D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-β signaling pathway by Chong Wang, Fangting Wang, Yanbo Wang, Linglin Fu

“…This study revealed the molecular mechanisms of D-tryptophan activity, provided D-tryptophan as a potential approach for cancer treatment, wound healing, organ development and other relevant applications.…”
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Indoor air quality in buildings: Assessment of exposure to enhanced natural radioactivity by Taoufiq Laila, Arrakhiz Fatimaezzahra, Guendouli El Mehdi, Chourak Mimoun

“…The equivalent radium activity (Raeq), internal (Hin) and external (Hex) risk indices, absorbed dose rate (Ḋ), annual effective dose (Ė) and excess lifetime cancer risk (ELCR) were also calculated. The surface (ES) and mass (EM) radon exhalation rates were calculated for the analysed samples in order to assess the radiological risks resulting from the use of coal ash concrete.The results has revealed no evidence of any health risks to the general public, and therefore coal ash concrete can be used in construction projects.…”
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Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma by Richard A. Peterson, Bhavani Kashyap, Pamala A. Pawloski, Anna C. Forsberg, Leah R. Hanson

“…It is unusual to have two separate intracranial primary cancers with each requiring a different chemotherapy regimen. …”
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A Comparison between Atlantic Canadian and National Correction Equations to Improve the Accuracy of Self-Reported Obesity Estimates in Atlantic Canada by Cynthia L. Murray, Gordon W. Walsh, Sarah Connor Gorber

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The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier... by Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella

“…Cellular uptake and DNA platination of Pt(IV) complexes were deeply investigated in the sensitive A2780 human ovarian cancer cell line and in the corresponding resistant A2780cisR subline. …”
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Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway by Huabing Yang, Pengjun Zhao, Shiliu Tian

“…Oxidative stress plays an imperative role in inflammation, diabetes mellitus, atherosclerosis, and cancer. In the present study, human aortic endothelial cells (HAECs) were employed to explore the anti-inflammatory activity of INN. …”
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Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents by Ajani Olayinka O., Nlebemuo Martins T., Adekoya Joseph A., Ogunniran Kehinde O., Siyanbola Tolutope O., Ajanaku Christiana O.

“…Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. …”
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Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells by James P. Maloney, Li Gao

“…Increased VEGF expression likely contributes to the pathogenesis of inflammatory lung diseases and to the angiogenic phenotype of lung cancer, a disease typically preceded by chronic inflammation.…”
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Synthesis and Characterization of Silver Nanoparticles Using Cannonball Leaves and Their Cytotoxic Activity against MCF-7 Cell Line by Preetha Devaraj, Prachi Kumari, Chirom Aarti, Arun Renganathan

“…Green synthesized silver nanoparticles by cannonball leaf extract show cytotoxicity to human breast cancer cell line (MCF-7). Overall, this environmentally friendly method of biological silver nanoparticles production provides rates of synthesis faster than or comparable to those of chemical methods and can potentially be used in various human contacting areas such as cosmetics, foods, and medical applications.…”
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Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data by Jinming Cheng, Xinyi Jin, Gordon K. Smyth, Yunshun Chen

“…Results We compared performance of five reference-based methods (SingleR, Azimuth, RCTD, scPred and scmapCell) with the marker-gene-based manual annotation method on an imaging-based Xenium data of human breast cancer. A practical workflow has been demonstrated for preparing a high-quality single-cell RNA reference, evaluating the accuracy, and estimating the running time for reference-based cell type annotation tools. …”
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