An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray by Handong Ouyang, Shue Liu, Weian Zeng, Roy C. Levitt, Keith A. Candiotti, Shuanglin Hao

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Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 by Omar Ramos-Lopez, Lidia Daimiel, Ana Ramírez de Molina, Diego Martínez-Urbistondo, Juan A. Vargas, J. Alfredo Martínez

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Performance Augmentation of Base Classifiers Using Adaptive Boosting Framework for Medical Datasets by Durr e Nayab, Rehan Ullah Khan, Ali Mustafa Qamar

“…The experiments are carried out on five datasets from the medical domain based on various types of cancers, i.e., global cancer map (GCM), lymphoma-I, lymphoma-II, leukaemia, and embryonal tumours. …”
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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling

“…Therapeutic protein products (TPP) have been widely used to treat a variety of human diseases, including cancer, hemophilia, and autoimmune diseases. However, TPP can induce unwanted immune responses that can impact both drug efficacy and patient safety. …”
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The Stability of a Model Substrate for Topoisomerase 1-Mediated DNA Religation Depends on the Presence of Mismatched Base Pairs by William H. Gmeiner, Freddie Salsbury, Chris M. Olsen, Luis A. Marky

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Breast Surgery Using Thoracic Paravertebral Blockade and Sedation Alone by James Simpson, Arun Ariyarathenam, Julie Dunn, Pete Ford

“…We present a series of 28 patients who received a TPVB with sedation alone for breast cancer surgery. Methods. A target controlled infusion of propofol or remifentanil was used for conscious sedation. …”
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Expression and characterization of exosomal miRNAs in healthy, sub-clinical mastitis and pasteurized milk of buffaloes by Korsapati L. Yoshitha, Shailesh D. Ingole, Simin V. Bharucha, Mandakranta Bhuyan, Rajesh R. Pharande, Rajiv V. Gaikwad

“…The miR-148a and miR-186, known to play roles in various diseases like cancer, can withstand commercial pasteurization and boiling, raising the intriguing possibility of transferring through milk exosomes. …”
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An agent-based model for elasto-plastic mechanical interactions between cells, basement membrane and extracellular matrix by Gianluca D'Antonio, Paul Macklin, Luigi Preziosi

“…The basement membrane (BM) and extracellular matrix (ECM) play critical roles in developmental and cancer biology, and are of great interest in biomathematics. …”
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Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCO3 Nanocrystals by Francesca Baldassarre, Viviana Vergaro, Federica De Castro, Francesca Biondo, Gian Paolo Suranna, Paride Papadia, Francesco P. Fanizzi, Domenico Rongai, Giuseppe Ciccarella

“…Furthermore, nanoformulations demonstrated a good antiproliferative activity in neuroblastoma and breast cancer cells carrying out a higher cytotoxic effect respect to free extract, confirming a crucial role of nanocarriers. …”
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Tumor de ángulo hepático del colon incarcerado en hernia umbilical. Reporte de caso by Amanda Rodríguez Chaviano, Mayquel Monzón Rodríguez, Dayner Alberto Ulloa Aguirre

“…Los tumores de colon ocupan la tercera causa de muerte por cáncer en Cuba. Los tumores de colon incarcerados en hernias umbilicales son raros. …”
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Functional Stability of Plasminogen Activator Inhibitor-1 by Songul Yasar Yildiz, Pinar Kuru, Ebru Toksoy Oner, Mehmet Agirbasli

“…The biological effects of PAI-1 extend far beyond thrombosis including its critical role in fibrotic disorders, atherosclerosis, renal and pulmonary fibrosis, type-2 diabetes, and cancer. The conversion of PAI-1 from the active to the latent conformation appears to be unique among serpins in that it occurs spontaneously at a relatively rapid rate. …”
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Long noncoding RNA DHRS4 antisense RNA 1 suppresses osteosarcoma cell proliferation and promotes apoptosis through a competitive endogenous RNA mechanism by Zhouzhou Tang, Zhihao Li, Guofeng Wu, Jianjun Li, Jianye Tan, Lixin Zhu

“…Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis. However, its function and molecular mechanism in OS remain largely unknown. …”
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The 500-year Cultural & Economic Trajectory of Tobacco: A Circle Complete by Christopher A. Jones, Amanda Wassel, William Mierse, E. Scott Sills

“…Solid epidemiological work connecting tobacco use with “the shortening of life span” began to appear in the medical literature in the 1950s, linking smoking with lung cancer and related conditions. In subsequent years, these developments led to significant curtailment of tobacco use. …”
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Rare skin adverse reactions induced by osimertinib: a case report and literature review by Ye Zhang, Mingzhu Ling, Min Wang, Ye Chen, Liting Zhang

“…Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in the treatment of EGFR mutation-positive advanced non-small cell lung cancer. Osimertinib-induced cutaneous vasculitis is a rare skin adverse reaction. …”
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The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials by Seidu A. Richard, Kuugbee D. Eugene

“…Posttranslational modifications are distinct approaches for the adjusted modification of EZH2 in the development of cancer. The amino acid succession of EZH2 protein makes it appropriate for covalent modifications, like phosphorylation, acetylation, O-GlcNAcylation, methylation, ubiquitination, and sumoylation. …”
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Prevalence of Microalbuminuria in Adult Patients with Sickle Cell Disease in Eastern Saudi Arabia by Ahmed M. Alkhunaizi, Adil A. Al-Khatti, Mansour A. Alkhunaizi

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Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma by Zhiyong Dong, Lingxin Xiong, Weijie Zhang, Peter G. Gibson, Ting Wang, Yanjiao Lu, Guoqiang Wang, Hui Li, Fang Wang

“…Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a complex heterogenous disease caused by genetic and environmental factors. …”
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GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers? by Romana Illig, Eckhard Klieser, Tobias Kiesslich, Daniel Neureiter

“…The GERD-Barrett-Adenocarcinoma sequence currently lacks well-defined diagnostic, progressive, predictive, and prognostic biomarkers (i) providing an appropriate screening method identifying the presence of the disease, (ii) estimating the risk of evolving cancer, that is, the progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC), (iii) predicting the response to therapy, and (iv) indicating an overall survival—prognosis for EAC patients. …”
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Electroanalytical Methods as a Tool for Determining the Antioxidant Capacity in Blood Samples by Fernanda Gonçalves de Oliveira, Thiago da Silveira Alvares, Rodrigo de Siqueira Melo

“… Aerobic metabolism is an essential process for energy production in cells, but it also generates reactive oxygen species (ROS), which, in excess, can cause cellular damage and contribute to the development of various diseases, such as cardiovascular diseases, cancer, and neurodegenerative disorders. The balance between ROS and antioxidants is crucial for health, as an imbalance can lead to oxidative stress, a significant risk factor for several clinical conditions. …”
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Smoking among pregnant women attending philanthropic maternity in São Paulo (Br by Natália Machado Costa Lopes, Maria Alice Tsunechiro, Alfredo Almeida Pina-Oliveira, Anna Maria Chiesa

“…About the harms to ma- ternal health, cancer was the most remembered. It was observed that it is necessary to intensify the approach of smoking at prenatal period, warning pregnant women about the risks and harms caused by cigarette for both the mother and the newborn, as there are still a lot of women who do not know basic information about the subject.…”
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