Implementation of patient-reported outcome dashboards within the electronic health record to support shared decision-making in serious chronic illness by Glyn Elwyn, Sheetal M Kircher, Eugene Nelson, David Cella, Lisa Hirschhorn, Cynthia Barnard, Vikram Aggarwal, Jeffrey Linder, Sofia F Garcia, Aricca Van Citters, Mary O'connor, Laura M Perry, Nisha A Mohindra, Ava Coughlin, Katy Bedjeti, Devin Peipert, Melissa Weitzel, Victoria Morken, Elijah Patten, Jissell Torres, Susan Metzger, Alesia O’daniel, Ryan Chmiel, Reena Modi, Michelle Munroe, Stavroula Xinos

“…However, few studies have evaluated real-world strategies and resulting implementation outcomes of PRO dashboards.Method From June 2020 to January 2022, we implemented an electronic health record (EHR)-integrated PRO dashboard for advanced cancer and chronic kidney disease. Based on implementation science guidelines (eg, Framework for Reporting Adaptations and Modifications to Evidence-based Implementation Strategies, Reach, Effectiveness, Adoption, Implementation, Maintenance), we monitored use and captured adaptations in implementation strategies. …”
Get full text

Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis by Hazel Ozuna, Hazel Ozuna, Dinesh Bojja, Santiago Partida-Sanchez, Luanne Hall-Stoodley, Amal Amer, Rodney D. Britt, Rodney D. Britt, Shahid Sheikh, David A. Frank, Weiyuan Wang, Bum-Yong Kang, Bum-Yong Kang, Irina Miralda, Irina Miralda, Samantha L. Durfey, Samantha L. Durfey, Benjamin T. Kopp, Benjamin T. Kopp

Get full text

Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the... by Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo

“…Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication that affects an increasing number of cancer survivors. However, the current treatment options for CIPN are limited. …”
Get full text

Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment by Koichi Egashira, Daisuke Sueta, Masafumi Kidoh, Mai Tomiguchi, Seitaro Oda, Hiroki Usuku, Kaori Hidaka, Lisa Goto‐Yamaguchi, Aiko Sueta, Takashi Komorita, Fumi Oike, Koichiro Fujisue, Eiichiro Yamamoto, Shinsuke Hanatani, Seiji Takashio, Satoshi Araki, Kenichi Matsushita, Yutaka Yamamoto, Toshinori Hirai, Kenichi Tsujita

“…Methods and results We prospectively investigated 15 consecutive breast cancer patients who were scheduled to receive anthracycline therapy. …”
Get full text

Ações na sala de espera de serviço de oncologia: relato de experiência by Danyelle Almeida Aragão, Glauton José Barroso Uchoa, Idilva Maria Pires Germano

“…O Projeto de Extensão Sala de Espera, iniciado em 2011, foi elaborado pelo Programa de Educação Tutorial de Psicologia da UFC para atuação no Centro Pediátrico do Câncer, em parceria com a Associação Peter Pan (Fortaleza), desenvolvendo ações de prevenção, promoção e reabilitação em Psico-oncologia. …”
Get full text

Hypophosphatemia after Right Hepatectomy for Living Donor Liver Transplantation by Kelly W Burak, Charles B Rosen, Jeff L Fidler, Gina K Hesley, David Nagorney, Michael R Charlton, David J Brandhagen

“…Hypophosphatemia has been described in patients undergoing right hepatectomy for liver cancer and in living donors for liver transplantation who also received total parenteral nutrition. …”
Get full text

Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage by Bosco Seong Kyu Yang, Spiros L. Blackburn, Philip L. Lorenzi, Huimahn A. Choi, Aaron M. Gusdon

Get full text

De novo design of protein minibinder agonists of TLR3 by Chloe S. Adams, Hyojin Kim, Abigail E. Burtner, Dong Sun Lee, Craig Dobbins, Cameron Criswell, Brian Coventry, Adri Tran-Pearson, Ho Min Kim, Neil P. King

“…Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine adjuvants in cancer and infectious disease, but present substantial manufacturing and formulation challenges. …”
Get full text

Antioxidant, Anti-Inflammatory, and Cytotoxic Activities of Garcinia nervosa (Clusiaceae) by N. M. U. Seruji, H. Y. Khong, C. J. Kutoi

“…For the cytotoxic assay, the extracts exhibited positive responses against the three cancer cell lines, the HeLa cell lines, MCF-7 cell lines, and HT-29 cell lines. …”
Get full text

Infection with hepatitis C virus as a cause of cirrhosis – case study by Lidia Sierpińska, Małgorzata Januszek

“…HCV may cause an acute or chronic hepatitis C and, when left untreated, may lead to cirrhosis and/or primary liver cancer. The aim of the study was analysis of personal medical records of a patient with cirrhosis from the aspect of its relation with HCV infection; Materials and Method. …”
Get full text

Comparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt by Safaa Yassin, Samah M. Elsohafy, Amr El-Hawiet, Maged S. Abdel-Kader, Doaa A. Ghareeb, Fikria A. Darwish, Masouda E. Amer

“…Overall, our findings indicate the potential for using active compounds of Annona squamosa L. cultivars to develop new therapeutic agents for cancer therapy and immune enhancement.…”
Get full text

From Bench to Bedside to Bug: An Update of Clinically Relevant Advances in the Care of Persons with Helicobacter pylori Associated Diseases by N Chiba, ABR Thomson, P Sinclair

“…The mode of transmission of H pylori remains unclear, and it remains unknown why only a small proportion of infected individuals develop duodenal or gastric ulcer disease and even fewer develop gastric cancer. The role of H pylori eradication in persons with uninvestigated dyspepsia remains controversial. …”
Get full text

New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia by Raha Orfali, Shagufta Perveen

“…All isolated metabolites were studied for their antibiotic effect against several pathogenic bacteria and for their cytotoxicity against the lymphoma human cancer cell line HTB-176. Austinol 3 exhibited strong antibacterial activity against P. aeruginosa bacterial strain with an MIC value of 0.13 ± 0.4 µg·mL−1, whereas emodin 4 demonstrated significant cytotoxicity against the tested HTB-176 cell line with an IC50 value of 2 ± 7.6 µM, while the other compounds were moderate to inactive with IC50 ranging from 4.3 ± 0.25–22 ± 2.94 µM in this assay.…”
Get full text

Detection of composition of functional component theabrownins in Pu-erh tea by degradation method by Simin Hu, Xiaolei Li, Chuangchuang Gao, Xianyu Meng, Mingchao Li, Yuqian Li, Tianrui Xu, Qian Hao

“…Pu-erh tea is one of the representatives of post-fermented teas, and the polymers in Pu-erh tea have anti-cancer and anti-hyperlipidemic activities, but their chemical composition is still unknown. …”
Get full text

Why are women still leaving academic medicine? A qualitative study within a London Medical School by Christopher J Peters, Lesley Regan, Victoria Salem, Clare Lloyd, Dhruti Hirani

Get full text

Hsa_circ_0000190 Promotes NSCLC Cell Resistance to Cisplatin via the Modulation of the miR-1253/IL-6 Axis by Hua He, Tian Li

“…This study explored the mechanistic basis for nonsmall cell lung cancer (NSCLC) cisplatin (DDP) treatment resistance in an effort to define effective approaches to abrogating the emergence of such chemoresistance. …”
Get full text

Secretory leukocyte protease inhibitor in punch biopsies from human colonic mucosa by Max Nyström, Ulla Peterson Westin, Carina Linder, Kjell Ohlsson

“…Normal colonic mucosa was sampled during surgery for colonic cancer. A total of 36 samples from four patients were used. …”
Get full text

Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling P... by Tsung-Chang Tsai, Wen-Tung Wu, Jen-Jie Lin, Jui-Hsin Su, Yu-Jen Wu

“…This study was performed to examine the mechanisms of the migration and invasion characteristics of HCC, with the aim of reducing metastasis by inhibiting cancer cell migration and invasion. In this study, we used Stellettin B, an active compound isolated from Stelletta sponges, as the experimental drug and evaluated its inhibition effects on cell migration and invasion in human hepatoma cells (HA22T and HepG2). …”
Get full text

Tumor Biomarker In-Solution Quantification, Standard Production, and Multiplex Detection by Nicole C. Japp, Joshua J. Souchek, Aaron R. Sasson, Michael A. Hollingsworth, Surinder K. Batra, Wade M. Junker

“…The diagnosis and monitoring of cancer have been facilitated by discovering tumor “biomarkers” and methods to detect their presence. …”
Get full text

Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new ent... by Zeliha Çelik, Naile Kökbudak, Fahriye Kilinç, Pembe Oltulu

“…Thyroid cancers are the most common endocrine organ cancers. …”
Get full text