Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

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Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model by José Sereno, Belmiro Parada, Flávio Reis, Fernanda X. Cunha, Edite Teixeira-Lemos, Patrícia Garrido, Rui Pinto, Petronila Rocha-Pereira, Paula Neto, José Ruivo, Paulo Rodrigues-Santos, Sara Nunes, Alfredo Mota, Arnaldo Figueiredo, Frederico Teixeira

“…To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment. …”
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Traitement d’un lymphome agressif chez un babouin naturellement infecté par STLV-1 by Jocelyn Turpin, Sandrine Alais, Ambroise Marçais, Julie Bruneau, Anat Melamed, Nicolas Gadot, Olivier Hermine, Charles Bangham, Romain Lacoste, Renaud Mahieux

“…En conclusion, les primates non-humains infectés naturellement par STLV-1 représentent un modèle unique permettant d’étudier la pathogenèse rétrovirale et l’évaluation de nouveaux traitements.Nous remercions l’INSERM, l’Ecole Normale Supérieure de Lyon, la Ligue Contre le Cancer (programme « équipe labellisée »), l’Association pour la Recherche sur le Cancer et la région Rhône Alpes programme ARC1.…”
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Automatic MRI Lymph Node Annotation From CT Labels by Souraja Kundu, Yuji Iwahori, M. K. Bhuyan, Manish Bhatt, Boonserm Kijsirikul, Aili Wang, Akira Ouchi, Yasuhiro Shimizu

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Exploring the barriers to cervical screening and perspectives on new self-sampling methods amongst under-served groups by Stephanie Gillibrand, Helen Gibson, Kelly Howells, Sean Urwin, Jennifer C. Davies, Emma J. Crosbie, Caroline Sanders

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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing by Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu

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Hubungan Kadar Laktat Dehidrogenase dengan Stadium Limfoma Maligna Non Hodgkin di Rumah Sakit Dr. M. Djamil Padang periode Desember 2009 sampai Maret 2013 by Dian Rahma Kasir, Irza Wahid, Hafni Bachtiar

“…Changing patterns of disease can be seen from the increased incidence of cancer as a cause of death in Indonesia in the last 10 years, ie from 12th to 6th order. …”
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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

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Faktor-faktor yang Berhubungan dengan Tingkat Pengetahuan Wanita Usia Subur Tentang “SADARI” di Nagari Painan by Vitro Darma Yusra, Rizanda Machmud, Yenita Yenita

“…</em><em></em></p><p><strong><em>Keywords: </em></strong><em>breast cancer,</em><em> risk</em><em> factor, prevention</em></p>…”
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A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…Background. Non-AIDS-defining cancers represent a rising health issue among HIV-infected patients. …”
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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…Recent evidence suggests that these drugs may contribute to bladder cancer. This study investigated molecular mechanism underlying effects of metformin and pioglitazone in bladder epithelial carcinogenesis in type 2 diabetes. …”
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Health promoting activities and corresponding mechanism of (–)-epicatechin-3-gallate by Zhiliang Li, Changchun Feng, Hongjin Dong, Weibin Jin, Wenying Zhang, Jianfeng Zhan, Shuzhen Wang

“…In particular, the gallate moiety of ECG is critical for mediating inhibitory effects towards cancer cells. Besides regulation of intracellular signaling pathways, ECG also inhibits RNase A and matrix metalloproteinase enzymatic activity via chelating metals (copper and zinc) in cancer cells. …”
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How to Analyze and Enhance Participation in Electronic Networks of Practice by Charkhsaz Fatemeh, Isaai Mohammad Taghi, Dayani Malihe

“…This study proposes an exploratory methodology for analyzing participation in Electronic Networks of Practice, focusing on a network of 500 specialists in breast cancer treatment as a case study. The research addresses a critical gap in understanding how conversational dynamics influence participation in professional forums. …”
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Delay equations modeling the effects of phase-specific drugs and immunotherapy on proliferating tumor cells by Maria Vittoria Barbarossa, Christina Kuttler, Jonathan Zinsl

“…Our model reproduces the dynamics of three different tumor cell populations: quiescent cells,cells during the interphase and mitotic cells.Starting from a partial differential equations (PDEs) setting, a delay differential equations (DDE) model is derived for aneasier and more realistic approach.Our equations also include interactions of tumor cells with immune system effectors.We investigate the model both from the analytical and the numerical point of view, give conditions forpositivity of solutions and focus on the stability of the cancer-free equilibrium. Differentimmunotherapeutic strategies and their effects on the tumor growth are considered, as well.…”
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Research Progress in Natural Sources, Biosynthesis and Metabolism Regulation of Rutin in Plant-Derived Food Materials by ZHOU Ting, WANG Haige, ZHANG Jixing, BAO Yingcai, YU Yongli, CHANG Jie

“…It possesses various pharmacological and physiological activities, including antioxidant, anti-aging, anti-inflammatory, anti-diabetic, and anti-cancer properties. With the deepening of pharmacological and physiological research on rutin, plant-derived foods rich in it have garnered significant research attention in the food industry. …”
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Experimental and Density Functional Theory Characteristics of Ibrutinib, a Bruton’s Kinase Inhibitor Approved for Leukemia Treatment by Ali I. Ismail

“…Ibrutinib, a Bruton’s tyrosine kinase that plays an essential role in the B-cell development and cancer cells, has been recently approved to treat chronic, lymphocytic, and other types of leukemia. …”
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Kyoto global consensus report on<i>Helicobacter pylori</i>gastritis: summary by A. A. Sheptulin

“…It is stressed, that the duly eradication therapy which is carried out before development of severe atrophy is capable to decrease the risk of stomach cancer. Conclusion. Proceedings and conclusions of consensus can become a cornerstone for development of new international gastritis classification.…”
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Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine by Hossein Omidian, Renae L. Wilson, Ana M. Castejon

“…The versatility of PLGA nanocarriers extends across therapeutic domains, including cancer therapy, neurodegenerative diseases, vaccine development, and regenerative medicine. …”
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Histological and Immunohistochemical Characterization of a Case of Endometriosis in a Guinea Pig (Cavia tschudii) by Alfonso Baldi, Andrea Lanza, Francesco Menicagli, Pietro G. Signorile, Enrico P. Spugnini

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PHYSIOLOGICAL EFFICACY OF MELANIN AS A FOOD INGREDIENT by N. Cherno, A. Kapustian, K. Naumenko, L. Gural, S. Osolina

“…Melanin has a wide range of biological effects that are beneficial to human health, including antioxidant activity, anti-inflammatory and cancer-protective effects, hypoglycemic and antihyperlipidemic properties, etc. …”
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